Pharmacological evaluation of the anxiolytic and sedative effects of Tilia americana L. var. mexicana in mice

HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. mexicana

“…As it was expected, all methanol extracts obtained from Mexican Tilia inflorescences collected from Omiltemi, Guerrero; Tenango de Doria, Hidalgo and, Coacoatzintla, Veracruz enhanced the duration of the sodium pentobarbital-induced hypnotic effect demonstrating its attributed depressant activity on the central nervous system (Aguirre-Hernández et al, 2007). In the same manner, an increased in the time spent in open-arms of the plus-maze by the range of doses experienced in mice from 10 to 300 mg/kg associated to sedation response mainly at higher doses was also observed.…”

“…Phytochemical studies of European Tilias have demonstrated that from Tilia argentea, Tilia cordata, Tilia phatyphyllos, and Tilia rubra have been isolated several flavonoids such as rutin (quercetin-3-O-rutinoside), hyperoside (quercetin-3-Ogalactoside), isoquercitrin (quercetin-3-O-glucoside), quercitrin (quercetin-3-O-rhamnoside), kaempferol-3-O-rhamnoside, astragalin (kaempferol-3-O-glucoside), tiliroside (kaempferol-3-O-(6-p-coumaryl)-glucoside), quercetin-3,7-dirhamnoside, kaempferol-3,7-dirhamnoside, quercetin-3-O-glucoside-7-Orhamnoside, and kaempferol-3-O-glucoside-7-O-rhamnoside (Pietta et al, 1993(Pietta et al, , 1994Toker et al, 2001Toker et al, , 2004Matsuda et al, 2002). In a previous study, it was demonstrated a significant and dose-dependant anxiolytic activity of a methanol crude extract (Aguirre-Hernández et al, 2007). However, structure of the active component(s) has not been described so far.…”

“…Around the world, Tilia species have been used for their tranquilizing properties in traditional medicine (Viola et al, 1994;Coleta et al, 2001;Aguirre-Hernández et al, 2007;Pérez-Ortega et al, 2008). Taxonomically, Tilia L. (Tiliaceae) is a difficult genus of nearly 25 species of which 17 species are present in East Asia, six in Europe and one in North America (Tang and Zhuge, 1996).…”

Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae)

“…Taxifolin, a member of flavonoids, has been shown to act as a potent antioxidant, anti-allergenic, anti-inflammatory and antinociceptive component (Cechinel Filho et al, 1998). Quercetin, isoquercitrin and chlorogenic acid were shown as main active compounds, including antiinflammatory, and antinociceptive activities (Aguirre-Hernández et al, 2007;Mariamawit et al, 2006). Apparently, these marker compounds in WET contribute to its antioxidant effects.…”

Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican Traditional Medicine

“…and methanol (10-300 mg/kg, i.p.) extracts of the inflorescences had an anxiolytic-like effect, and at higher doses it produced a decrease in the ambulatory activity (Aguirre- Hernández et al, 2007a). The anxiolytic activity was determined by EPM, hole board test (HBT), and exploratory rearing.…”