Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of morinda lucida benth. in normal and alloxan- induced diabetic rats

Abstract

In the present study, 50 -400

Antidiabetic and Antilipidemic Effect of Khaya senegalensis Ethanolic Bark Extract in Alloxan Induced Diabetic Wistar Rats

“…The diabetic orthodox group showed a significant decrease (p<0.05) in blood glucose concentration when compared to diabetic control but the decrease was not significant compared to the extract treated group D1 and D2. Reduction in blood glucose level by most bioactive compounds from plants might occur through one of several mechanisms including increased repair or proliferation of the beta-cells and stimulation of insulin secretion Adeneye and Agbaje (2008). This mechanism of action depicted the underlying principle through which the ethanolic bark extracts of Khaya senegalensis reduced blood glucose concentration.…”

Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes

“…However, in developing countries and in some developed countries, these therapeutic options are expensive, and not readily accessible, especially to the poor (Adeneye and Agbaje, 2008). Aside these, the therapeutic regimen are considered rigid, multipharmaceutical, and often associated with intolerable side effects (Adeneye and Agbaje, 2008).…”

Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats

“…Modern drugs, including insulin and other oral hypoglycaemic agents such as sulfonylureas and biguanides are known to control blood glucose levels but with side effects 2 . Besides, these drugs are expensive and not readily accessible in developing countries 3 . Hence, herbal remedy may be a potential alternative for the management of diabetes since they contain compounds with antioxidant activity that can play a role in protection against damage induced during diabetes 4 .…”