Pharmacological evaluation of "Glyoherb": A polyherbal formulation on streptozotocin-induced diabetic rats

Abstract

In the present study, powdered suspension of ‘Glyoherb’- sugar control granules, a polyherbal formulation (manufactured by Dhanvantri Guj. herb., Valasan, Anand, Gujarat, India) was evaluated for its antihyperglycemic, antihyperlipidemic and antioxidant effects against normal and streptozotocin-induced diabetic rats. Type I diabetes was induced when streptozotocin 70 mg/kg was administered as a single i.p. injection. After five days of streptozotocin injection, animals showing glycosuria (fasting blood sugar level >200 mg/dl) were considered as diabetic. Daily oral administration of ‘Glyoherb’ suspension in 200, 400 and 600 mg/kg doses for 28 days produced a dose-dependant decrease in blood glucose levels. It also produced a significant decrease in elevated serum triglyceride, cholesterol, VLDL, LDL, atherogenic index, serum urea, and creatinine and in antioxidant parameters in a dose dependant manner. Results were analyzed using one way ANOVA followed by Tukey's test. No significant changes were noticed in blood glucose, serum lipid levels and kidney parameters in normal rats treated with ‘Glyoherb’ suspension alone. The efficacy of ‘Glyoherb’ suspension as an antihyperglycemic, antihyperlipidemic and antioxidant agent in streptozotocin-induced diabetes was comparable to that of the standard drug Glibenclamide (5 mg/kg).

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

“…It had also shown to increase HDL levels 117 Glyoherb did not exert any toxic effects in STZ-induced impaired kidney and liver functions rather it improved the kidney and liver functions. 117 On the other hand, Diabeta Plus is also an antidiabetic polyherbal formulation that has additional properties of potent immunomodulator, antihyperlipidemic, anti-stress and is hepatoprotective. 115 Monotherapy of Diabeta works by attacking various factors that can precipitate diabetic condition thus preventing or delaying the complications in pre-diabetics.…”

“…115 Results in animal testing suggested that it increases glucose tolerance and lowers blood glucose levels in STZ-induced type 1 diabetic rats. 117 Additionally, treatment with Glyoherb has shown to reduce serum cholesterol, TGs, VLDL, LDL levels compared to control groups but is not as effective as glibenclamide. It had also shown to increase HDL levels 117 Glyoherb did not exert any toxic effects in STZ-induced impaired kidney and liver functions rather it improved the kidney and liver functions.…”

“… 117 Additionally, treatment with Glyoherb has shown to reduce serum cholesterol, TGs, VLDL, LDL levels compared to control groups but is not as effective as glibenclamide. It had also shown to increase HDL levels 117 Glyoherb did not exert any toxic effects in STZ-induced impaired kidney and liver functions rather it improved the kidney and liver functions. 117 On the other hand, Diabeta Plus is also an antidiabetic polyherbal formulation that has additional properties of potent immunomodulator, antihyperlipidemic, anti-stress and is hepatoprotective.…”

Antidiabetic Activity ofArtemisia amygdalinaDecne in Streptozotocin Induced Diabetic Rats

“…Glibenclamide was given at a dose of 3 mg/kg of body weight [22, 23]. The oral administration of crude extracts (different extracts with different concentrations) was continued once daily at the same time for 14 days.…”

The effect of polyherbal medicines used for the treatment of tuberculosis on other opportunistic organisms of humans infected with tuberculosis

“…[ 3 ] Due to the wide therapeutic range and high efficiency of polyherbal formulations, they are used for the treatment of a vast number of diseases such as diabetics, arthritis, liver and kidney disorders, cough, asthma, fever, respiratory disorders, and tuberculosis (TB). [ 4 5 6 7 8 9 ]…”