Pharmacological effects of the combined administration of a small dose of Acetylsalicylic acid and methyldopa in ADMA-like preeclampsia

Abstract

Background: Hypertensive disorders, in particular preeclampsia, which accounts for 2 to 8% of the total number of pregnancies in the world, are one of the leading causes of serious complications, prolonged disability and death in mothers and babies. In the structure of perinatal mortality, hypertensive disorders during pregnancy account for up to 25% of the total number of cases, and also occupy the leading places in the structure of causes of maternal mortality. The aim of the study: to study the protective activity of a small dose of acetylsalicylic acid and its combination with methyldopa in the correction of ADMA-like preeclampsia. Materials and methods: The study was performed on 150 female Wistar rats weighing 250-300 g. An ADMA-like model of preeclampsia was reproduced in the experiment. The following parameters were used to assess emerging morphofunctional disorders like blood pressure, coefficient of endothelial dysfunction, microcirculation in the placenta, proteinuria, fluid content in the greater omentum, concentration of final metabolites in blood plasma, fetal morphometric parameters. Results: When assessing morphofunctional disorders in animals with ADMA-like preeclampsia, the study has revealed a positive effect of a small dose of acetylsalicylic acid in combination with methyldopa. Conclusion:The combined administration of a small dose of acetylsalicylic acid and methyldopa has a pronounced protective activity in the correction of morphofunctional disorders in animals with ADMA-like preeclampsia and is a promising direction in the treatment of hypertensive disorders during pregnancy.