Pharmacological effects and mechanisms of muscone

Wang, Jun; Xing, Hui; Qin, Xuzhen; Ren, Qun; Jiang, Yang; Li, Lin

doi:10.1016/j.jep.2020.113120

Cited by 41 publications

(20 citation statements)

References 72 publications

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“…Regarding to muscone, its antioxidant activity has been mentioned in various reports [ 17 , 18 , 25 ]. For instance, Du et al [ 25 ] showed that muscone attenuated lipopolysaccharide-induced ROS formation in bone marrow-derived macrophages.…”

Section: Resultsmentioning

confidence: 99%

“…Musk, well known as a high-value crude drug in traditional Chinese medicine, is produced from ventral glandular secretion of the male musk deer, and is widely applied in pain relief, promotion of blood flow, and resuscitation. In addition, muscone (3-methylcyclopentadecanone, Figure 1 ), the key compound regulating the odor of musk, also possesses several valuable pharmaceutical activities such as anti-early pregnancy, anti-cerebral ischemia, anti-cancer, neuroprotective, and cardioprotective effects [ 17 ]. Previous reports have shown that muscone has a protective effect on various normal cell lines, including neurons and cardiac myocytes.…”

Section: Introductionmentioning

confidence: 99%

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Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells

et al. 2020

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Cisplatin, one of the most common antitumor agents, is widely applied to treat various cancerous diseases and is included in the World Health Organization Model List of Essential Medicines. Cisplatin therapy is used to treat 10–20% of all cancerous cases, and its cure rate is especially high in testicular cancer (over 90%). However, a major side effect of this anticancer drug is nephrotoxicity, limiting treatment effect and reducing the quality of life in cancer patients. Muscone, an odoriferous constituent of musk, was confirmed to inhibit cisplatin-induced LLC-PK1 kidney proximal tubule cell death in a dose-dependent manner. In term of renal protective mechanism, muscone inhibited cisplatin oxidative toxicity by decreasing reactive oxygen species (ROS) level and stimulating HO-1 expression. Muscone also exerted anti-inflammation effect through inhibition of p38 phosphorylation. Furthermore, muscone mitigated cisplatin-induced apoptosis in LLC-PK1 cells via both intrinsic and extrinsic pathways by inhibiting pro-apoptotic protein Bax expression, and cleaved caspase-3, 7, and 8; and increase of anti-apoptotic protein Bcl-2 level. In addition, the anti-apoptotic effect of muscone also was enhanced by preventing p53 expression and its phosphorylation. Our study showed that muscone may be a potential protective agent against cisplatin-induced nephrotoxicity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells

et al. 2020

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“…GVM has comprehensive functions due to the combination of the integral effects of moxibustion and the specificity of Chinese herbal medicines (musk and white peony). Previous studies have demonstrated that the water-soluble components of musk are anti-inflammatory in various animal models, and the ingredients of musk glycoprotein have significant inhibitory effects on the chemotaxis of neutrophils [ 21 , 22 ]. Meanwhile, glucosides extracted from peony have immunosuppressive effects on arthritis based on the rat model, which indicates the potential benefit of peony in the treatment of rheumatoid arthritis [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Governor Vessel Moxibustion Therapy Improves Microbiota Structure in Ankylosing Spondylitis Patients

et al. 2021

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Background. Clinical studies have shown that ankylosing spondylitis (AS) could be significantly improved by Governor Vessel moxibustion (GVM) therapy. Objective. Study whether GVM therapy alleviates the clinical symptoms of AS by modulating intestinal microbiota. Methods. A total of 9 AS patients and 9 paired healthy individuals were enrolled, and GVM therapy was provided to the AS patients. Stool, urine, and saliva samples from the healthy individuals and the AS patients before and after GVM therapy were collected, and 16S rRNA gene sequencing was performed for microbiota analysis. Results. We found that GVM therapy can significantly alleviate the symptoms of AS, such as diarrhea, abdominal pain, and bloating. GVM therapy also decreased the abundances of Bacteroides and Prevotella while increasing the abundances of beneficial bacteria, such as Lactobacillus, in the gut microbiota of the AS patients. The analyses for AS clinical data and microbial abundances in AS patients revealed their multiple significant correlations ( P < 0.01 ); for example, an unclassified crystal was positively correlated with AF12 and Delftia, monocyte had a negative correlation with Scardovia, and human leukocyte antigen-B27 was negatively correlated with Catenibacterium, Coprococcus, and Oscillospira. Conclusions. Overall, these findings demonstrate that GVM therapy can alleviate AS clinical symptoms, and at the same time, it improves the microbial structure of microbiota in AS patients. This trial is registered with Chinese Clinical Trial Registry ChiCTR2100051907.

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“…The malignant proliferation, invasion, and metastasis of tumor cells are the most important problems in the development of tumors (Guo et al., 2014 ; Zheng et al., 2015 ). Muscone has inhibitory effects against breast and liver cancers in vitro (Bitsch et al., 2002 ; Qi et al., 2020 ; Wang et al., 2020 ). However, the strength and mechanism of action of muscone's anti‐cancer effects remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Muscone suppresses gastric cancer via regulation of miRNA‐145

Gao

Yan

Sun

et al. 2021

Food Science & Nutrition

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Muscone is the primary functional component of the natural musk produced by animals such as the musk deer and muskrat. It is usually extracted from the musk sacs or dry exocrine secretions of mature male musk deer (Wang et al., 2020). Some studies have reported that muscone exerts anti-inflammatory effects (Du et al., 2018;He et al., 2020). However, it remains unclear whether muscone exerts antitumor effects in gastric cancer.MicroRNAs (miRNAs) are a class of small, single-stranded, noncoding RNAs that are found widely in eukaryotic cells. miRNAs are 19-25 nucleotides in length and serve important biological functions such as regulating downstream gene transcription by binding to mRNA transcripts of target genes (Hannafon & Ding, 2018).

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Pharmacological effects and mechanisms of muscone

Cited by 41 publications

References 72 publications

Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells

Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells

Governor Vessel Moxibustion Therapy Improves Microbiota Structure in Ankylosing Spondylitis Patients

Muscone suppresses gastric cancer via regulation of miRNA‐145

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