Pharmacological basis of the anxiolytic and antidepressant properties of Silexan®, an essential oil from the flowers of lavender

Müller, Walter E.; Sillani, Giacomo; Schuwald, Anita; Friedland, Kristina

doi:10.1016/j.neuint.2020.104899

Cited by 19 publications

(15 citation statements)

References 64 publications

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“…Lavender oil administered by different routes has been recognized for centuries for promoting "well-being" and for reduction of distress [9]. Lavender, a plant from the Lamiaceae family, comes in many species with different chemical characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…Silexan, a proprietary essential oil from Lavandula angustifolia flowers, has been approved in Germany and several other countries for the oral treatment of anxiety [9]. Silexan® showed pronounced anxiolytic effects in patients with subthreshold anxiety disorders [13,14] at a daily oral dose of 80 mg (1 capsule) as well as in anxietyrelated restlessness and agitation [15] and generalized anxiety disorder for daily single doses of 80 mg and 160 mg [16e18].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis

Kim

Nam

Lee

et al. 2021

Asian Nursing Research

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The recent evidence suggested substantial anxiolytic efficacy of lavender. The aim of this study was to examine the efficacy of lavender for anxiety, depression, and physiological parameters and to elucidate the differential effects of lavender on anxiety and depression by study characteristics. Methods: A systematic review and meta-analysis was performed following the PRISMA guidelines. We searched PubMed, Embase, Cochrane Library, Web of Science, and Cumulative Index of Nursing and Allied Health Literature databases for randomized controlled trials investigating the efficacy of lavender on anxiety, depression, or physiological parameters in humans. We assessed the risk of bias within studies with the revised Cochrane risk of bias tool for randomized trials. We used random effect model to estimate the average effect and computed bias-corrected standardized mean difference as effect size metric, Hedges' ĝ for all outcomes. Results: Lavender was superior to placebo or no treatment in reducing anxiety (Hedges' ĝ ¼ À0.72, 95% confidence interval [CI] À0.90 to À0.55, p value <.001), depression (Hedges' ĝ ¼ À0.43, 95% CI, À0.59 to À0.27, p value <.001), and systolic blood pressure (Hedges' ĝ ¼ À0.23, 95% CI, À0.41to À0.05, p value ¼ .01). The moderator analysis by meta-regression indicated that route of administration accounted 6.5% (p value ¼ .187) for the heterogeneity in anxiolytic effects, sessions of treatment accounted 13.2% (p value ¼ .055), and participants' health state accounted 8.9% (p value ¼ .131) for the variance in anxiolytic effects. Conclusion: Lavender aromatherapy showed substantial effect in reducing anxiety and depression, and sessions of administration increased the anxiolytic effects. The effects on physiological parameters showed small with inconsistent significances and randomized controlled trials on the effect of lavender on depression were scarce. Future trials on depression and physiological parameters are recommended, and increasing the sessions of administration is recommended.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis

Kim

Nam

Lee

et al. 2021

Asian Nursing Research

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“…Lavandula angustifolia Mill., Lavandula stoechas L., Lavandula latifolia Medik., and Lavandula × intermedia are the four major species of lavender. The EOs of Lavandula species are very well known for their myriad of pharmacological, toxicological, and pharmaceutical properties [ 146 , 147 , 217 , 218 , 256 , 257 ] ( Table 1 ).…”

Section: Allelopathy Of Major Lamiaceae Generamentioning

confidence: 99%

Allelopathic Properties of Lamiaceae Species: Prospects and Challenges to Use in Agriculture

Islam

Suttiyut

Anwar

et al. 2022

Plants

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Herbicide resistance due to the increasing reliance on herbicides is a near-term challenge for the world’s agriculture. This has led to a desire to develop new herbicides with a novel mode of action, to address resistance in weed species. Lamiaceae, a large dicotyledonous plant family, is very well known for the multitudinous pharmacological and toxicological properties of its member species. Moreover, many species of this family are significant for their allelopathic activity in natural and laboratory settings. Thus, plants in Lamiaceae have the potential to be sources of alternative herbicides. However, gaps in our knowledge need to be addressed prior to adopting these allelopathic activities in agriculture. Therefore, we review the existing state of knowledge about the Lamiaceae family, the reported allelopathic properties of plant extracts, and their isolated allelochemicals under laboratory, greenhouse, and field conditions. In addition, we offer a perspective on existing challenges and future opportunities for adopting the allelopathic properties of Lamiaceae plant species for green agriculture.

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“…Silexan besteht aus ca. 160 Bestandteilen, wobei die Hauptinhaltsstoffe Linalool und Linalylacetat sind 19 . Das ätherische Öl entspricht der Monografie Lavendelöl des Europäischen Arzneibuchs (Ph.Eur.)…”

Section: Lavendelunclassified

Lavendel bei Angststörungen – Schwerpunkt Lavendelöl

Volz¹

2022

Zeitschrift für Phytotherapie

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ZusammenfassungAngststörungen sind als Gruppe betrachtet die häufigsten psychiatrischen Erkrankungen überhaupt, die Ein-Jahres-Prävalenz beträgt 14%. In dem vorliegenden Beitrag werden zunächst die wichtigsten klinischen Charakteristika dieser Erkrankungen vorgestellt und wie zu einer differentialdiagnostischen Einschätzung gelangt werden kann. Die wichtigsten Behandlungsmethoden für diese Störungen sind Psychotherapie und Pharmakotherapie. Bei letzterer Option besitzt das Phytopharmakon Silexan einen besonderen Stellenwert, da dessen Effektivität und Verträglichkeit in einer Reihe von doppelblinden, meist placebokontrollierten Studien im Indikationsbereich subsyndromale Angststörungen und generalisierte Angststörung gezeigt werden konnten; auch Metaanalysen über diese Studien bestätigten diese günstigen Ergebnisse. Zudem liegen Interaktionsstudien und spezielle Studien zur Fahrfähigkeit und zu dem Fehlen von Absetzeffekten vor. Insofern stellt Lavendelöl eine wertvolle Alternative zur Pharmakotherapie der Angststörungen dar.

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Pharmacological basis of the anxiolytic and antidepressant properties of Silexan®, an essential oil from the flowers of lavender

Cited by 19 publications

References 64 publications

Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis

Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis

Allelopathic Properties of Lamiaceae Species: Prospects and Challenges to Use in Agriculture

Lavendel bei Angststörungen – Schwerpunkt Lavendelöl

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