Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: Anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents

Souza, Maíra Ribeiro de; Paula, Carmen Aparecida de; Resende, Michelle Luciane Pereira de; Grabe‐Guimarães, Andrea; Filho, José Dias de Souza; Saúde-Guimarães, Dênia Antunes

doi:10.1016/j.jep.2012.06.012

Cited by 80 publications

(63 citation statements)

References 30 publications

(44 reference statements)

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“…The mechanism of sesquiterpene lactones action against T. cruzi, including LYC, is still unknown. However, the presence of alkylant groups in the LYC molecule could be responsible for these activities (14,16,17,18).…”

Section: Discussionmentioning

confidence: 99%

“…The anti-T. cruzi activity of LYC in vitro was first reported by Oliveira et al (14). This substance presents many other activities (15)(16)(17), including clastogenic and cytotoxic effects (18). Despite its pharmacological potential, the therapeutic application of LYC is limited due to its physicochemical properties that hamper oral administration, such as poor aqueous solubility, high lipophilicity (log P ϭ 5.03), and potential chemical instability in alkaline media (13).…”

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confidence: 97%

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Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Branquinho

Mosqueira

Oliveira-Silva

et al. 2014

Antimicrob Agents Chemother

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dThe drugs available for Chagas disease treatment are toxic and ineffective. We studied the in vivo activity of a new drug, lychnopholide (LYC). LYC was loaded in nanocapsules (NC), and its effects were compared to free LYC and benznidazole against Trypanosoma cruzi. Infected mice were treated in the acute phase at 2.0 mg/kg/day with free LYC, LYC-poly--caprolactone NC (LYC-PCL), and LYC-poly(lactic acid)-co-polyethylene glycol NC (LYC-PLA-PEG) or at 50 mg/kg/day with benznidazole solution by the intravenous route. Animals infected with the CL strain, treated 24 h after infection for 10 days, evaluated by hemoculture, PCR, and enzyme-linked immunosorbent assay exhibited a 50% parasitological cure when treated with LYC-PCL NC and 100% cure when treated with benznidazole, but 100% of the animals treated during the prepatent period for 20 days with these formulations or LYC-PLA-PEG NC were cured. In animals with the Y strain treated 24 h after infection for 10 days, only mice treated by LYC-PCL NC were cured, but animals treated in the prepatent period for 20 days exhibited 100, 75, and 62.5% cure when treated with LYC-PLA-PEG NC, benznidazole, and LYC-PCL NC, respectively. Free LYC reduced the parasitemia and improved mice survival, but no mice were cured. LYC-loaded NC showed higher cure rates, reduced parasitemia, and increased survival when used in doses 2five times lower than those used for benznidazole. This study confirms that LYC is a potential new treatment for Chagas disease. Furthermore, the long-circulating property of PLA-PEG NC and its ability to improve LYC efficacy showed that this formulation is more effective in reaching the parasite in vivo.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Branquinho

Mosqueira

Oliveira-Silva

et al. 2014

Antimicrob Agents Chemother

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“…Its inhibitory activity against XOD has been confirmed in mice after oral ingestion. In addition, luteolin suppressed enhancement of hepatic XOD activity enhanced by oxonate which induces hyperuricemia [19,20]. Moreover, luteolin suppresses nitric oxide production by uric acid in pancreatic β-cells, which exacerbates diabetic complications [21].…”

Section: Backgroundsmentioning

confidence: 99%

Luteolin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia

Hirano¹,

Takeda²,

Hitoe³

et al. 2017

Integr Mol Med

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Background: Luteolin is a flavonoid found in various edible plants that exhibits diverse health benefits, including anti-inflammatory and anti-gout effects. However, there has been little clinical investigation of luteolin from the viewpoint of gout prevention. We conducted a clinical trial of supplementation with chrysanthemum flower extract rich in luteolin (LCE) to assess the effect on serum uric acid levels in Japanese men.

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“…In previous studies, eremantholide C and its oxidized derivatives showed activity against Trypanosoma cruzi (Oliveira et al 1996, Saúde-Guimarães et al 2007). Other biological/pharmacological activities were reported for eremantholide C, such as antibacterial, anti-hyperuricemic, anti-gouty arthritis, anti-inflammatory and antitumor (Barrero et al 2000, Saúde et al 2002, de Souza et al 2012, DÊNIA A. SAÚDE-GUIMARÃES, DÉLIO S. RASLAN, EGLER CHIARI and ALAÍDE B. DE OLIVEIRA Ferrari et al 2013, Saúde-Guimarães et al 2014).…”

Section: Introductionmentioning

confidence: 93%

Complete assignments of NMR data and assessment of trypanocidal activity of new eremantholide C derivatives

Saúde-Guimarães

Raslan

Chiari

et al. 2014

An. Acad. Bras. Ciênc.

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Chemical transformations of eremantholide C (1), a sesquiterpene lactone that was isolated from Lychnophora trichocarpha Spreng. led to five new derivatives: 1',2'-epoxyeremantholide C (2), 5-n-propylamine-4,5-dihydro-1',2'-epoxyeremantholide C (3), 5-n-propylammonium-4,5-dihydro-1',2'-epoxyeremantholide C chloride (4), 5-n-propylammonium-4,5-dihydroeremantolide C chloride (5) and 16-O-ethyleremantholide C (6). The structures of all these derivatives were assigned on the basis of IR, MS, 1 H and 13 C NMR data by 1D and 2D techniques. Eremantholide C and the derivatives 2, 4 and 5 were evaluated against trypomastigotes Y and CL strains of Trypanosoma cruzi. Eremantholide C completely inhibited the growth of both the parasites strains while all derivatives were partially active against the CL strain and inactive against the Y strain.

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Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: Anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents

Abstract: Ethanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possesses both anti-hiperuricemic and anti-inflammatory properties.

Cited by 80 publications

References 30 publications

Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

Luteolin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia

Complete assignments of NMR data and assessment of trypanocidal activity of new eremantholide C derivatives

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