Pharmacological Aspects of the Use of Lipoic Acid (Review)

Usacheva, Anna; Chernikov, A. V.; Karmanova, E. E.; Брусков, В. И.

doi:10.1007/s11094-022-02549-7

Cited by 8 publications

(6 citation statements)

References 122 publications

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“…α‐Lipoic acid (ALA), first isolated and characterized by Lester Reed and coworkers in 1951, [1] has been extensively studied for pharmaceutical and nutraceutical potentials regarding its antioxidant and anti‐inflammatory properties [2–5] . Besides the regulation of the redox status in cells through thiol/disulfide exchange reactions, [3,6,7] ALA acts as an essential cofactor for α‐ketoacid dehydrogenase complexes (e. g., pyruvate dehydrogenase, PDH) in the cellular energy metabolism [8,9] .…”

Section: Introductionmentioning

confidence: 99%

Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity

Liu

Barth

Cseh

et al. 2022

Chemistry & Biodiversity

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α-Lipoic acid, known for its anti-inflammatory and antioxidant activity, represents a promising ligand for Pt(IV) prodrugs. Three new Pt(IV) lipoate complexes were synthesized and characterized by NMR spectroscopy ( 1 H, 13 C, 195 Pt), mass spectrometry and elemental analysis. Due to the low solubility of the complex containing two axial lipoate ligands, further experiments to examine the biological activity were performed with two Pt(IV) complexes containing just one axial lipoate ligand. Both complexes exhibit anticancer activity and produce reactive oxygen species (ROS) in the cell lines tested. Especially, the monosubstituted complex can be reduced by ascorbic acid and forms adducts with 9-methylguanine (9MeG), which is favorable for the formation of DNA-crosslinks in the cells.

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Section: Introductionmentioning

confidence: 99%

Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity

Liu

Barth

Cseh

et al. 2022

Chemistry & Biodiversity

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“…L ipoic acid (LA) is a natural compound, chemically it is (R)-5-(1, 2-dithiolan-3-yl) pentanoic acid (Usacheva et al, 2022). Lipoic acid is predominantly a lipophilic molecule with an amphipathic characteristic due to the carboxylic acid group attached to the ring structure.…”

Section: Introductionmentioning

confidence: 99%

Ameliorating the Cardiovascular Disorders after Ovariectomy By Alpha Lipoic Acid Supplementation

Rwayyih,

Al-Azawi

2024

AAVS

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The present experiment was designed to study the protective role of ALA on some biological cardiac markers include creatinine phosphokinase, C-reactive protein and troponin and histology of heart and aorta in intact and ovariectomized rabbits. Twenty rabbits, aged seven to eight weeks, were employed in this investigation. The animals were split up evenly into the following four groups: The intact rabbits in Group One (G1) were given distilled water. The intact rabbits in Group Two (G2) were given an oral dose of alpha lipoic acid (10 mg/kg B.wt). The ovariectomized rabbits in Group Three (G3) were given distilled water. Group four (G4) Ovariectomized rabbits received alpha lipoic acid (10mg/kg B.wt) orally. The results reveal that supplemented groups show a significant decrease in CPK, CRP and troponin serum level. Moreover, there is an increase in heart index (0.45% and 0.41%) as compared with none supplemented intact and ovariectomized groups (0.43% and 0.35%) respectively. The histological sections of the heart from the supplemented groups show no clear lesions with normal spindle shape cardiac muscle and intercalated disc with normal aorta and epithelial cells. From the other hand, the ovariectomized non-supplemented rabbits show clear lesions in their heart and aorta. There was clear necrosis of cardiac muscle fibers with fatty change in endocardium or papillary muscles due to estrogen deficiency, irregular myocardial endothelial degeneration and congested blood vessels. The aorta of these groups has enlargement and thickening of endothelial cells with infiltration of fatty cells in tunica intimae (The structure of intima changes in postmenopausal and it becomes multilayered due to migration of smooth muscle cells from the media to intima). In conclusions, the result of the current study could prove that Alpha lipoic acid has a protection on cardiovascular system in menopause estrogen deficiency and ovariectomized female rabbits. Alpha lipoic acid could fight the deleterious effect of menopause estrogen deficiency.

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“…Moreover, α-lipoic acid at a high dosage negatively affected the liver enzyme activity and induced liver damage in mice and monkeys [ 66 , 72 ]. Also, its supplementation may lower blood sugar levels in genetically predisposed individuals, which can be problematic for diabetic individuals [ 73 ]. Finally, α-lipoic acid may interact with certain medications, including chemotherapy drugs, thyroid medications, and drugs that lower blood sugar levels.…”

Section: Introductionmentioning

confidence: 99%

“…Some in vitro and in vivo studies have indicated the pro-oxidant potential of α-lipoic acid, whether in the oxidised form or DHLA [ 73 , 74 , 75 ]. The result of this effect with either beneficial or detrimental outcomes depends on the specific physiological circumstances, although the pro-oxidant activity of α-lipoic acid has been associated with cardiovascular, renal, and liver damages [ 73 , 74 , 75 ].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

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α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, and targeted delivery. Nanoformulations of α-lipoic acid can significantly enhance its solubility and absorption, making it more bioavailable. While α-lipoic acid can be prone to degradation in its free form, encapsulation within nanoparticles ensures its stability over time, and its release in a controlled and sustained manner to the targeted tissues and cells. In addition, α-lipoic acid can be combined with other compounds, such as other antioxidants, drugs, or nanomaterials, to create synergistic effects that enhance their overall therapeutic benefits or hinder their potential cytotoxicity. This review outlines the advantages and drawbacks associated with the use of α-lipoic acid, as well as various nanotechnological approaches employed to enhance its therapeutic effectiveness, whether alone or in combination with other bioactive agents. Furthermore, it describes the engineering of α-lipoic acid to produce poly(α-lipoic acid) nanoparticles, which hold promise as an effective drug delivery system.

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Pharmacological Aspects of the Use of Lipoic Acid (Review)

Cited by 8 publications

References 122 publications

Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity

Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity

Ameliorating the Cardiovascular Disorders after Ovariectomy By Alpha Lipoic Acid Supplementation

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

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