Pharmacological Aspects and Therapeutic Effects of Ursodeoxycholic Acid

Leuschner, U.; Kurtz, W

doi:10.1159/000171236

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Cited by 10 publications

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Ursodeoxycholic acid and taurine as therapy for cholestatic liver disease

Chan

Lake

1991

Hepatology

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A, Hasiba U, et al. Patterns of hypothalamic-pituitary-gonadal dysfunction in men with liver disease due to differing etiologies. HEPATOLOGY 198 1 ; 1: 39-46. Van Thiel D, Kumar S, Gavaler J , Tarter R. Effect of liver transplantation on the hypothalamic-pituitary-gonadal axis of chronic alcoholic men with advanced liver disease. Alcohol Clin Penn I, Makowski E, Harris P. Parenthood following renal and hepatic transplantation.

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Ursodeoxycholic acid and taurine as therapy for cholestatic liver disease

Chan

Lake

1991

Hepatology

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Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy

et al. 1992

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The efficacy and safety of ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy was investigated in an open pilot study. Five patients received 1 gm/day of ursodeoxycholic acid during 20 days and another three patients received two identical periods of treatment separated by a 14-day interval free of the drug. Pruritus and serum levels of total bile salts and glutamic-pyruvic transaminase improved significantly during treatment with ursodeoxycholic acid. In the three patients who received two periods of treatment with ursodeoxycholic acid, pruritus and the laboratory alterations relapsed in the second week after the drug was discontinued, but they improved again when ursodeoxycholic acid was readministered. No adverse reactions were detected in the mothers or in their babies. All newborns were thriving normally during a follow-up period that lasted 5 mo after delivery. It is concluded that UDCA appears to be safe when administered in late pregnancy; its promising efficacy in the treatment of intrahepatic cholestasis of pregnancy should now be confirmed in controlled clinical trials.

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Treatment of liver diseases

2006

Hepatology Principles and Practice

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Pharmacological Aspects and Therapeutic Effects of Ursodeoxycholic Acid

Cited by 10 publications

References 5 publications

Ursodeoxycholic acid and taurine as therapy for cholestatic liver disease

Ursodeoxycholic acid and taurine as therapy for cholestatic liver disease

Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy

Treatment of liver diseases

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