Pharmacological application of barium containing bioactive glass in gastro-duodenal ulcers

Pankaj, Pankaj; Kumar, Ankush; Tripathi, Himanshu; Singh, Sukhwinder; Patne, Shashikant C. U.; Krishnamurthy, Sairam

doi:10.1016/j.msec.2018.06.068

Cited by 21 publications

(39 citation statements)

References 52 publications

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“…Acute, chronic, recurrent and ulcer protection models, via various injury mechanisms, for gastric and duodenal ulcers were utilized across these studies. Commercially available 45S5 and a tailor-made BG were compared to drugs currently used for the treatment of GERD or PUD; hydrotalcite, an antacid, and omeprazole, a commonly used PPI. , …”

Section: Discussionmentioning

confidence: 99%

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Harrop,

Tupally,

Pandey

et al. 2023

Mol. Pharmaceutics

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Bioactive glasses (BGs) are widely used in orthopedic and dental applications for their ability to stimulate endogenous bone formation and regeneration. BG applications more recently broadened to include soft tissue conditions, based on their ability to stimulate angiogenesis, soft tissue regeneration, and wound healing. Sol−gel synthesis has helped facilitate this expansion, allowing formulators to tailor the morphological characteristics of the BG matrix. The effectiveness of BGs in skin wound healing is viewed as a gateway for their use as both a therapeutic and drug delivery platform in other soft tissue applications, notably gastrointestinal (GI) applications, which form the focus of this review. Recent changes in international guidelines for GI conditions shifted clinical objectives from symptom management to mucosal wound healing. The additional scrutiny of proton pump inhibitor (PPI) safety, increasing burden of disease, and financial costs associated with gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), and inflammatory bowel disease (IBD) open new clinical possibilities for BG. This narrative literature review intersects materials engineering, formulation science, and clinical practice, setting it apart from prior literature. Broadly, current evidence for BG applications in GI conditions is sparse and under-developed, which this review directly addresses. It explores and synthesizes evidence that supports the potential use of sol− gel-derived BG for the efficacious treatment of soft tissue applications, with specific reference to GI conditions. An overview with comparative analysis of current BG synthesis techniques and associated challenges is presented, and influences of composition, biologically active ions, and morphological characteristics in soft tissue applications are explored. To contextualize this, sol−gelderived BGs are proposed as a dual, tailorable therapeutic and drug delivery platform for upper and lower GI conditions. Future directions for this largely untapped area of translational research are also proposed, based on extant literature.

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Section: Discussionmentioning

confidence: 99%

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Harrop,

Tupally,

Pandey

et al. 2023

Mol. Pharmaceutics

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“…Moreover, in the same study, the ability of Ba 2+ to prevent the lipopolysaccharide-induced amplification of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10) was evaluated indicating the anti-inflammatory effect of this ion [ 9 ]. In another approach, Paliwal et al [ 159 ] synthesized melt-derived Ba-doped 45S5 BGs (1.3 BaO mol%) and evaluated their effect on gastro-duodenal ulcers. After soaking in SBF on days 6 and 7, Ba-doped BGs exhibited higher pH values than 45S5 BG, indicating that Ba-containing BGs may have an enhanced antacid-like effect over 45S5 BG.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

“…The results of the study revealed that Ba-BGs enhanced cell proliferation in the pyloric-induced gastric model and produced a protective layer on gastric and duodenum epithelium in the ethanol-induced gastric ulcer model. Furthermore, it was concluded that Ba-45S5 BGs in the dose of 3 mg/kg prevented and healed gastric-duodenal ulcers induced by different ulcerogens [ 159 ]. For cancer hyperthermia applications, the combination of magnetic properties and bioactive behavior of Ba-containing BGs is gaining attention.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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“…damaged or injured tissues, the NPs then exert their beneficial pharmacological actions and appreciably aid in ameliorating disease activity indices via various mechanisms. 11,12 Recently, we have synthesized smaller-sized copper-oxide (Cu I/II O) nanoparticles capped with thiol-functionalized cellulose for an azide−alkyne cycloaddition reaction under environmentally friendly conditions. 13 In our previous work, 14,15 bigger-sized (20−52 nm) copper-oxide NPs supported by a polymeric backbone of homogeneous, watersoluble, thiol-functionalized cellulose colloidal dispersion were used for Glaser coupling reactions.…”

Section: Introductionmentioning

confidence: 99%

“…Nanotechnology in general and nanoparticle-mediated disease alleviation, in particular, have recently been undertaken for in-depth research and developmental activities. Because of the defective and leaky vasculature in injured, damaged, or inflamed tissues, nanoparticles possess the capability of getting leaked out of these blood vessels and get specifically lodged into the injured localizations. − After getting accumulated in damaged or injured tissues, the NPs then exert their beneficial pharmacological actions and appreciably aid in ameliorating disease activity indices via various mechanisms. , …”

Section: Introductionmentioning

confidence: 99%

Cellulose-Conjugated Copper-Oxide Nanoparticles for the Treatment of Ethanol-Induced Gastric Ulcers in Wistar Rats

Kumar¹,

Selim²,

Gowri³

et al. 2022

ACS Biomater. Sci. Eng.

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Gastric ulcer (GU) is the most common and chronic inflammatory condition mediated by multiple immune cells like neutrophils, macrophages, and lymphocytes with multiple pro-inflammatory cytokine interleukins such as IL-8, IL-10, IL-β, and interferon-γ (IFN-γ). Copper (Cu) is one of the essential micronutrients mainly found in the liver and brain. It plays a major role in metabolism, enzyme conversion, free radical scavenging, trafficking agents, and many others. Due to its various roles in the biological system, it can also be used as a therapeutic agent in many diseases like colon cancer, bone fracture healing, angiogenesis, as an antibacterial, wound-healing and radiotherapeutic agents. In this study, we used thiol-functionalized cellulose-conjugated copper-oxide nanoparticles (CuI/IIO NPs) synthesized under environmentally friendly conditions. We have evaluated the effects of cellulose-conjugated CuI/IIO NPs against ethanol-induced gastric ulcer in Wistar rats. The cellulose-conjugated CuI/IIO NPs were evaluated against different physical, histochemical, and inflammatory parameters. The NPs promoted mucosal healing by ameliorating ulcerative damage, restoring the histoarchitecture of gastric mucosa, and inhibiting pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), and other inflammatory biomarkers such as myeloperoxidase (MPO) activity and nitric oxide (NO) levels. The current study’s findings suggest that cellulose-conjugated CuI/IIO NPs exerted antiulcer effects on the preclinical rat model and have promising potential as a novel therapeutic agent for the treatment of gastric ulcers.

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Pharmacological application of barium containing bioactive glass in gastro-duodenal ulcers

Cited by 21 publications

References 52 publications

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Cellulose-Conjugated Copper-Oxide Nanoparticles for the Treatment of Ethanol-Induced Gastric Ulcers in Wistar Rats

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