Biochemical Pharmacology volume 81, issue 3, P337-344 2011 DOI: 10.1016/j.bcp.2010.11.008 View full text
Lucio G. Costa, Gennaro Giordano, Clement E. Furlong

Abstract: AbstractParaoxonase 1 (PON1) is a high density lipoprotein (HDL)-associated enzyme displaying esterase and lactonase activity. PON1 hydrolyzes several organophosphorus (OP) insecticides and nerve agents, a number of exogenous and endogenous lactones, and metabolizes toxic oxidized lipids of low density lipoproteins (LDL) and HDL. As such, PON1 plays a relevant role in determining susceptibility to OP toxicity, cardiovascular diseases and several other diseases. Serum PON1 activity in a given population can va…

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