Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

Zárate, Rafael; Portillo, Eduardo; Teixidó, Sílvia; Carvalho, M. A. A. Pinheiro de; Nunes, Nuno; Ferraz, Sonia Maria Taddei; Seca, Ana M. L.; Rosa, Gonçalo Pereira; Barreto, Maria Carmo

doi:10.3390/app10175831

Cited by 22 publications

(24 citation statements)

References 76 publications

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“…Similar to our results, eight of the most active samples from 15 materials of beach-cast seaweeds exhibit antitumoral activity against lung cancer and breast cancer with low IC 50 values (Zárate et al, 2020). These findings reinforce the importance of this underused waste biomass.…”

Section: Cytotoxicity Activitysupporting

confidence: 90%

“…Our study formulated cosmetic products with antioxidant activity and photoprotective capacity using aqueous and hydroethanolic extracts from beach-cast algae and other ingredients used in natural cosmetics, but low SPF values were obtained in the present study. Zárate et al (2020) showed that methanolic and hydroethanolic extracts from 15 materials of beach-cast seaweeds from Portugal presented UV protection, with SPF values above 30.…”

Section: Photoprotectionmentioning

confidence: 99%

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Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Harb¹

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A wide variety of metabolites extracted from macroalgae is currently used as functional food ingredients, natural nutraceuticals, biomedical materials, cosmetic formulations, as well as in other products that promote human health. One of the major limitations in the search for new extracts or natural products with biological action is the lack of available biomass for studies and even for their bioprospection. In this context, the availability of beach-cast marine algae is a sustainable and highly productive alternative. The main objective of this study was to evaluate the chemical and bioactive potential of extracts from 15 materials of beach-cast marine algae collected from the Brazilian coast to provide subsidies that allow identifying the potentialities and its uses as functional product. The findings showed that the highest antioxidant activities were found in extracts from brown beach-cast algae followed by the extracts of red beach-cast algae, and the lowest activities were detected in the green beach-cast species. The most efficient extracts of beach-cast species with antioxidant properties were from Dictyopteris jolyana, Zonaria tournefortii, and Osmundaria obtusiloba. Regarding antiviral activity, the aqueous extract of Codium isthmocladum and methanolic extracts from D. jolyana, Z. tournefortii Alsidium seaforthii, Spiridia clavata and O. obtusiloba were highly promising, reaching inhibition percentage above 90%. The extracts of Z. tournefortii, A, seaforthii and C. isthmocladum showed high cytotoxicity activity against the tumoral cells strains HL60 (leukemia) and HTC116 (colon) and did not show any cytotoxicity activity against non-tumoral human cells (HGF1). Currently, the large amount of beach-cast seaweeds deposited on the beaches of Brazil is collected and treated as trash, being incinerated or disposed in landfills by the government. Instead of using public resources and making efforts for the removal of this biomass, it is possible to propose different uses for the Brazilian beach-cast seaweeds and transform it into applications for several sectors. Due to the antioxidant, antiviral, nutritional, photoprotective and cytotoxic properties reported for macroalgae, such applied features bring environmental benefits by mitigating coastal pollution generating a usable resource, in addition to ensuring sustainable social and economic development. The review data shown in the literature of Brazilian beach-cast algae shows the relevance and innovation of this study. This is the first report evaluating chemical composition, antioxidant potential, antiviral activity, cytotoxicity potential and photoprotection of extracts from beach-cast algae from the Brazilian coast. The potential of beach-cast seaweeds provides raw-material for several applications, combined with the large amount available on the beaches of certain regions at the Brazilian coast can be better exploited. The present study significantly contributes to increasing knowledge of Brazilian beach-cast algae and their potential uses as well as t...

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Section: Cytotoxicity Activitysupporting

confidence: 90%

Section: Photoprotectionmentioning

confidence: 99%

Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Harb¹

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“…Among them, seaweeds represent a sustainable and renewable resource, gaining increasing attention for these applications [16,17]. Furthermore, valorization of waste seaweeds, such as beach-casts, which are disposed of in landfills without commercial value, could represent an attractive low-cost source for cosmeceutical industries [18]. Similarly, the valorization of invasive species could contribute to the creation of natural and ecofriendly ingredients for the cosmetic industry [19] while also contributing to the restoration of affected environments.…”

Section: Introductionmentioning

confidence: 99%

Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics

et al. 2021

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The interest in seaweeds for cosmetic, cosmeceutics, and nutricosmetics is increasing based on the demand for natural ingredients. Seaweeds offer advantages in relation to their renewable character, wide distribution, and the richness and versatility of their valuable bioactive compounds, which can be used as ingredients, as additives, and as active agents in the formulation of skin care products. Bioactive compounds, such as polyphenols, polysaccharides, proteins, peptides, amino acids, lipids, vitamins, and minerals, are responsible for the biological properties associated with seaweeds. Seaweed fractions can also offer technical features, such as thickening, gelling, emulsifying, texturizing, or moistening to develop cohesive matrices. Furthermore, the possibility of valorizing industrial waste streams and algal blooms makes them an attractive, low cost, raw and renewable material. This review presents an updated summary of the activities of different seaweed compounds and fractions based on scientific and patent literature.

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“…Seaweeds are considered renewable natural resources found abundantly in the Philippine coastline, yet the commercial and pharmaceutical use of these organisms are largely untapped. In other countries, several studies had documented different types of biological activities in seaweeds showing the promising use of these algae as rich source of bioactive compounds (Kim et al 2014;Chang and Teo 2016;Phasanasophon and Kim 2018;Zarate et al 2020;Lee et al 2020;Susano et al 2021;Baek et al 2021). However, reports on the bioactive properties of seaweeds in the Philippines are still limited (Canoy and Bitacura 2018;Arguelles 2020;Magdugo et al 2020;Arguelles 2021b;Arguelles and Sapin 2020a, b, c).…”

Section: Introductionmentioning

confidence: 99%

“…The IC 50 value of S. aquifolium extract is considered more potent than that obtained for Asparagopsis armata (IC 50 value = 2.50-3.387 mg/mL), Lobophora variegata (IC 50 value = > 250.0 μg/mL), and Dictyota sp. (IC 50 value = > 250.0 μg/mL) but is less effective to other brown seaweeds such as Agarum cribrosum (IC 50 value = 16.13 μg/mL) and Carpomitra costata (IC 50 value = 4.0 μg/mL)(Phasanasophon and Kim 2018;Zarate et al 2020;Lee et al 2020;Susano et al 2021).…”

mentioning

confidence: 99%

Chemical Composition and Bioactive Properties of Sargassum aquifolium (Turner) C. Agardh and Its Potential for Pharmaceutical Application

Arguelles¹,

Sapin²

2021

Philipp J Sci

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Seaweeds are known sources of marine bioactive substances with diverse biological activities important in the synthesis of medically important novel drugs. The proximate and elemental compositions as well as bioactive properties of a brown macroalga, Sargassum aquifolium (Turner) C. Agardh, were studied. Results showed that proximate composition of S. aquifolium contain high carbohydrate (32.29 ± 0.17%) and ash (30.19 ± 0.14%) content. Elemental composition of the seaweed exhibited a decreasing order of Na > Ca > K > Mg > Mn > Fe > Zn > Cu > Pb > Cr > Cd. The seaweed had a total phenolic content (TPC) of 5.74 ± 0.04 mg GAE/g. Antioxidant activities of S. aquifolium were characterized by having potent ABTS+ [2,2’-azino-bis (3-ethylbenzothiazoline- 6-sulfonic acid)] scavenging activity and high copper reduction capacity with IC50 value of 107 μg/mL and 21.01 μg/mL respectively. Evaluation of tyrosinase and elastase inhibition activities showed that S. aquifolium extract has potent inhibition activities with IC50 of 39.00 μg/mL and IC50 of 231.00 μg/mL, respectively – more effective than kojic acid and tocopherol. In addition, in vitro assessment of α-glucosidase and α-amylase inhibition property showed that S. aquifolium extract has potent inhibitory activity as compared to acarbose (standard anti-diabetic drug) with IC50 of 15.60 and 59.0 μg/mL, respectively. Also, the S. aquifolium extract exhibited effective antimicrobial activities against bacterial pathogens such as penicillin acylase-producing Bacillus cereus (MIC = 125 μg/mL), Staphylococcus saprophyticus (MIC = 250 μg/mL), methicillin-resistant Staphylococcus aureus (MRSA) (MIC = 250 μg/mL), Staphylococcus epidermidis (MIC = 250 μg/ mL), and Pseudomonas aeruginosa (MIC = 500 μg/mL). The current investigation is a pioneering study in the Philippines that shows the potential of S. aquifolium as novel source of bioactive compounds with important use for pharmaceutical applications.

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Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

Cited by 22 publications

References 76 publications

Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics

Chemical Composition and Bioactive Properties of Sargassum aquifolium (Turner) C. Agardh and Its Potential for Pharmaceutical Application

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