Pharmacological and biochemical properties of Zingiber zerumbet (L.) Roscoe ex Sm. and its therapeutic efficacy on osteoarthritis of knee

Ahmadabadi, Hassan Kiani; Vaez-Mahdavi, Mohammad Reza; Kamalinejad, Mohammad; Shariatpanahi, Seyed Shamsa; Ghazanfari, Tooba; Jafari, Fatemeh

doi:10.4103/jfmpc.jfmpc_594_19

Cited by 5 publications

(4 citation statements)

References 65 publications

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“…Zingiber zerumbet can function as a biomedical such as anti-proliferative, anti-inflammatory, and antioxidant effects (Ahmadabadi et al 2019). Traditionally Z. cassumunar has been used as a medicine to treat diseases such as inflammation, pain, and respiratory problems and it also functions as an antioxidant, anti-inflammatory, anticancer, neuroprotective/neurotropic, cosmetic, and antifungal/antimicrobial bioactivity (Han et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Ethnobotany of medicinal plants in the Dayak Linoh Tribe in Sintang District, Indonesia

Julung

Supiandi²,

EGE³

et al. 2023

Biodiversitas

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Abstract. Julung H, Supiandi MI, Ege B, Zubaidah S, Mahanal S. 2023. Ethnobotany of medicinal plants in the Dayak Linoh Tribe in Sintang District, Indonesia. Biodiversitas 24: 767-775. The Linoh Dayak people have long used medicinal plants to deal with health problems in their community. However, along with the advancement of science, the influx of foreign cultures and the degradation of nature and the environment, traditional knowledge about medicinal plants is only owned by the older generation, and the transmission of information is limited by word of mouth and not well documented. This study aimed to document various medicinal plants used by the Dayak Linoh people. The research used a qualitative approach using field surveys. Informants were selected using the purposive sampling method. The informants interviewed consisted of customary leaders (key informants), village heads (main informants), and recommended informants, such as traditional birth attendants (village midwives), hamlet heads, and community members who know medicinal plants. Medicinal plant data were obtained through in-depth interviews, participatory observation, and documentation related to the local names of the plants, the parts used, and how to manage and use them. Data analysis was carried out in a qualitative descriptive manner. The results showed that 55 species of medicinal plants consisting of 34 plant families were used by the Dayak Linoh tribe. The most widely used part of the plant is the leaf (39, 71%). People in the community boiled the leaves and drank the extract. The most used families in the three tribal communities of the Dayak Linoh tribe, were Zingiberaceae (9 species) and Myrtaceae (3 species). The plant parts used by the Dayak Linoh tribe were root, tuber, rhizome, stem, bark, banana heart, fruit, fruit skin, leaf, and seed. The Dayak Linoh tribe used medicinal plants to treat boil (7 plants) and for postpartum stamina recovery (7 plants). The communities processed and used the medicinal herbs conventionally by boiling and drinking.

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Section: Discussionmentioning

confidence: 99%

Ethnobotany of medicinal plants in the Dayak Linoh Tribe in Sintang District, Indonesia

Julung

Supiandi²,

EGE³

et al. 2023

Biodiversitas

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“…Z. zerumbet, commonly known as "shampoo ginger", is found across southern China (Guangdong, Guangxi, Hainan and Yunnan provinces), most of Southeast Asia, Myanmar, India, and Sri Lanka [1][2][3][4]. Zerumbone from the Z. zerumbet rhizome has been reported to suppress the phagocytic activity of human neutrophils [9], to prevent and treat tooth decay disease [10], to cure osteoarthritis of the knee [11], and to treat various immune-inflammatory related disorders [12].…”

Section: Introductionmentioning

confidence: 99%

Complete chloroplast genomes of Zingiber montanum and Zingiber zerumbet: Genome structure, comparative and phylogenetic analyses

et al. 2020

PLoS ONE

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Zingiber montanum (Z. montanum) and Zingiber zerumbet (Z. zerumbet) are important medicinal and ornamental herbs in the genus Zingiber and family Zingiberaceae. Chloroplast-derived markers are useful for species identification and phylogenetic studies, but further development is warranted for these two Zingiber species. In this study, we report the complete chloroplast genomes of Z. montanum and Z. zerumbet, which had lengths of 164,464 bp and 163,589 bp, respectively. These genomes had typical quadripartite structures with a large single copy (LSC, 87,856-89,161 bp), a small single copy (SSC, 15,803-15,642 bp), and a pair of inverted repeats (IRa and IRb, 29,393-30,449 bp). We identified 111 unique genes in each chloroplast genome, including 79 protein-coding genes, 28 tRNAs and 4 rRNA genes. We analyzed the molecular structures, gene information, amino acid frequencies, codon usage patterns, RNA editing sites, simple sequence repeats (SSRs) and long repeats from the two chloroplast genomes. A comparison of the Z. montanum and Z. zerumbet chloroplast genomes detected 489 single-nucleotide polymorphisms (SNPs) and 172 insertions/deletions (indels). Thirteen highly divergent regions, including ycf1, rps19, rps18-rpl20, accD-psaI, psaC-ndhE, psbA-trnK-UUU, trnfM-CAU-rps14, trnE-UUC-trnT-UGU, ccsA-ndhD, psbC-trnS-UGA, start-psbA, petA-psbJ, and rbcL-accD, were identified and might be useful for future species identification and phylogeny in the genus Zingiber. Positive selection was observed for ATP synthase (atpA and atpB), RNA polymerase (rpoA), small subunit ribosomal protein (rps3) and other protein-coding genes (accD, clpP, ycf1, and ycf2) based on the Ka/Ks ratios. Additionally, chloroplast SNP-based phylogeny analyses found that Zingiber was a monophyletic sister branch to Kaempferia and that chloroplast SNPs could be used to identify Zingiber species. The genome resources in our study provide valuable information for the identification and phylogenetic analysis of the genus Zingiber and family Zingiberaceae.

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“…Zerumbone (ZER) is a phytochemical compound isolated from the rhizome of Zingiber zerumbet , a ginger plant often known as Lempoyang in Malaysia 11,12 . The biological activities encompass a range of features, such as antibiofilm and antibacterial effects, wound healing capabilities, anticancer activity, anti‐inflammatory properties, immunosuppressive effects and numerous others 13–18 .…”

Section: Introductionmentioning

confidence: 99%

“…Zerumbone (ZER) is a phytochemical compound isolated from the rhizome of Zingiber zerumbet, a ginger plant often known as Lempoyang in Malaysia. 11,12 The biological activities encompass a range of features, such as antibiofilm and antibacterial effects, wound healing capabilities, anticancer activity, anti-inflammatory properties, immunosuppressive effects and numerous others. [13][14][15][16][17][18] In addition to the aforementioned actions, Oh et al (2018) have documented that ZER possesses the capacity to inhibit the synthesis of melanin pigments using stem cell factors (SCF)-induced modulation of the MITF and MC1R/α-MSH signaling pathway.…”

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confidence: 99%

Skin lightening properties of zerumbone cream: A placebo‐controlled study

Kuek,

Tiang,

Yow

et al. 2024

J of Cosmetic Dermatology

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ObjectiveDespite the demonstrated anti‐melanogenic and UV protective effects of Zerumbone (ZER) in vitro, there is a lack of clinical trials that have been done to assess these properties. The primary objective of this study was to assess the effectiveness of ZER in lightening the skin tone of human participants with a single‐blind approach.MethodsTwenty‐six participants were randomly assigned to two groups to investigate the application location (left or right volar forearm) for the placebo and ZER creams. Both creams were topically administered to the volar forearms twice daily over a duration of 4 weeks. Initial skin irritation was assessed before and 30 min after applying creams. The melanin and erythema levels were quantified with Mexameter MX 18.ResultsTwenty participants were included in the analysis. The cream formulation had excellent physical properties and was well‐received by the participants. The initial skin irritation study results indicated that neither of the creams elicited an allergic reaction. The administration of ZER cream resulted in a statistically significant reduction in melanin levels (p < 0.05) after 1 week compared to the initial baseline. Furthermore, after 2 weeks of application, ZER cream demonstrated significant differences in melanin levels compared to placebo (p < 0.05). No adverse effects were observed in the group using ZER cream.ConclusionZER demonstrated significant potential as a skin‐lightening agent.

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Pharmacological and biochemical properties of Zingiber zerumbet (L.) Roscoe ex Sm. and its therapeutic efficacy on osteoarthritis of knee

Cited by 5 publications

References 65 publications

Ethnobotany of medicinal plants in the Dayak Linoh Tribe in Sintang District, Indonesia

Ethnobotany of medicinal plants in the Dayak Linoh Tribe in Sintang District, Indonesia

Complete chloroplast genomes of Zingiber montanum and Zingiber zerumbet: Genome structure, comparative and phylogenetic analyses

Skin lightening properties of zerumbone cream: A placebo‐controlled study

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