Pharmacological Activity of Sesquiterpene Lactones

Matejić, Jelena S.; Šarac, Zorica; Ranđelović, Vladimir

doi:10.1080/13102818.2010.10817819

Cited by 30 publications

(19 citation statements)

References 17 publications

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“…SLs, derived from a natural product and a subfamily of terpenoids, have been reported to exhibit numerous potential medicinal properties, including anti-inflammatory, antimicrobial and anticancer actions, in in vitro and in vivo studies, as well as clinical trials (13,(18)(19)(20). More than 5,000 SLs have been identified from Asteraceae spp.…”

Section: Discussionmentioning

confidence: 99%

Anti‑breast cancer potential of frullanolide from Grangea maderaspatana plant by inducing apoptosis

et al. 2019

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Breast cancer is the leading cause of female mortality worldwide. Although there are several modern treatments for breast cancer, there is a high rate of recurrence for the majority of treatments; therefore, the search for effective anticancer agents continues. The present study aimed to investigate the anti-breast cancer potential of frullanolide, a compound which is isolated and purified from the Grangea maderaspatana plant, for selected human breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231). The MTT assay was used to assess cytotoxic activity in breast cancer cell lines of treatment with frullanolide at 1.25, 2.5, 5.0, 10.0 and 20.0 µg/ml. Additionally, the apoptotic induction ability of frullanolide at various concentrations [0.5x, 1x and 2x half maximal inhibitory concentration (IC 50)] was investigated by flow cytometry and western blot analysis. Frullanolide exhibited strong anti-breast cancer activity against MDA-MB-468 (IC 50 , 8.04±2.69 µg/ml) and weak cytotoxicity against the MCF-7 (IC 50 , 10.74±0.86 µg/ml) and MDA-MB-231 (IC 50 , 12.36±0.31 µg/ml) cell lines. The IC 50 of frullanolide was high in the human normal epithelial breast cell line (MCF-12A) and mouse fibroblast cell line (L-929). Density plot diagrams revealed that frullanolide induced apoptosis in MCF-7, MDA-MB-468 and MDA-MB-231 cells. Notably, a plausible anticancer mechanism was elucidated via cellular apoptosis by p53-independence in the treated MCF-7 cell line and p53-dependence in the treated MDA-MB-468 and MDA-MB-231 cell lines. In conclusion, the present study demonstrated that frullanolide may exert anticancer activity on breast cancer cell lines by inducing apoptosis. Frullanolide offers a possible novel approach to breast cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Anti‑breast cancer potential of frullanolide from Grangea maderaspatana plant by inducing apoptosis

et al. 2019

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“…Sesquiterpene lactones have been isolated from all plant organs, but they most commonly occur in leaves and glandular trichomes on leaves. The wide variety of chemical structures is responsible for their distinctive biological activity, which is connected with the presence of α,β-unsaturated γ-lactone ring [ 5 , 6 ]. All sesquiterpene lactones, which have a lactone ring coupled with an exo-methylene, enables inhibition of the cellular enzymes through Michael nucleophilic addition [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

Nawrot

Budzianowski

Nowak

et al. 2021

IJMS

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Three germacranolides, as well as five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of Stizolophus balsamita growing in Iran. The paper presents active compounds found for the first time in the inflorescence of this species. The flavonoids, simple phenolic compounds and natural steroids have been isolated for the first time in the genus Stizolophus. The MTT assay was employed to study in vitro cytotoxic effects of the taxifolin against human fibroblasts. We also evaluate the possible biological properties/cosmetic effects of Stizolophus balsamita extract and taxifolin on the human skin. Sixty healthy Caucasian adult females with no dermatological diseases were investigated. We evaluate the effects of S. balsamita extract and taxifolin on skin hydration and transepidermal water loss (TEWL). It was revealed that S. balsamita extract might decrease TEWL level and fixed the barrier function of the epidermis. The presence of bioactive phytochemical constituents in S. balsamita inflorescences makes them a valuable and safe source for creating new cosmetics and medicines.

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“…They express some allelopathic potential as well. Nowadays, greater attention is paid to sesquiterpene lactones due to their cytotoxic and anticancer activity (Matejić et al, 2010).…”

Section: Pharmacologymentioning

confidence: 99%

Phyto-pharmacological aspects of Nepeta nuda L.: A systematic review

Aćimović¹,

Jeremić

Cvetković

2020

Lekovite sirovine

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Nepeta nuda L. (syn. N. pannonica L.) is a herbaceous perennial plant that is the most widespread species of the genus Nepeta, the largest genera in Lamiaceae family. N. nuda is divided into four subspecies according to morphological differences which occur within large geographical range of distribution: subsp. nuda, subsp. albiflora, subsp. lydiae, and subsp. glandulifera. In this review, previous reports on N. nuda concerning its botanical description and systematics, phytochemistry, use in traditional medicine, pharmacology, and posibilities for other applications were summarized. All of these data indicate N. nuda as a highly promising species for application in food and pharmaceutical industries, as well as in agriculture for the development of natural pesticides.

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Pharmacological Activity of Sesquiterpene Lactones

Cited by 30 publications

References 17 publications

Anti‑breast cancer potential of frullanolide from Grangea maderaspatana plant by inducing apoptosis

Anti‑breast cancer potential of frullanolide from Grangea maderaspatana plant by inducing apoptosis

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

Phyto-pharmacological aspects of Nepeta nuda L.: A systematic review

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