Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

Clarke, Shari; Nelson, Amanda M.; George, Rosalyn; Thiboutot, Diane

doi:10.1016/j.det.2007.01.004

Cited by 37 publications

(39 citation statements)

References 71 publications

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“…Among other factors, it is a result of the increase in androgen production [4,5] that leads to the excessive production of sebum, the abnormal detachment of keratinocytes, the obstruction of the follicle opening and, as a consequence, the development of microcomedones [6]. The activation of nuclear hormone receptors, particularly the activation of peroxisome proliferator-activated receptor ligands, may regulate lipogenesis in human sebaceous glands [7,8].…”

Section: Introductionmentioning

confidence: 99%

Androgenic Hormone Profile of Adult Women with Acne

Cunha¹,

Fonseca²,

Machado

2013

Dermatology

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Acne in adult women is a hard-to-manage frequent disease with many relapse cases. It mostly interferes with quality of life and causes major social and metabolic losses for patients. This is a transversal retrospective study and the aim was to standardize the research on circulating androgenic hormone levels and to detect hyperandrogenic states early, showing the frequency and the pattern of the altered hormones, useful resources to correctly evaluate each patient. In this study 835 women above 15 years of age, with acne or aggravation cases, were analyzed. The aim was to verify the percentage of androgen examinations with levels above normal. The levels of the hormones dehydroepiandrosterone sulfate, dehydroepiandrosterone (DHEA), dehydrotestosterone, androstenedione and total testosterone were measured in all patients. The evaluation of the hormone profile showed that 54.56% of the patients had hyperandrogenism, and the levels of DHEA were most frequently elevated. Therefore, in the face of the importance of hyperandrogenism in the pathogenesis of acne, standardizing the research of the hormone profile is paramount for the treatment and control of relapses in case of a surge of acne breakouts during a woman's adult life.

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Section: Introductionmentioning

confidence: 99%

Androgenic Hormone Profile of Adult Women with Acne

Cunha¹,

Fonseca²,

Machado

2013

Dermatology

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“…14,12,15 It has been suggested that chronic stress might be a possible cause of increased androgen secretion in some of the women, resulting in the pathogenesis of acne in such patients. 16 Several such reports have been published regarding the association of increased level of cortisol and emotional stress. 17 In the present study, 51% knew that acne can be aggravated by stress.…”

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confidence: 99%

Knowledge, attitude and practice towards acne vulgaris among acne patients

et al. 2017

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Background: Acne is a chronic inflammatory disease known to occur in adolescent age group. There are many myths and misconceptions in patients as well as health physicians regarding the causes and treatment of acne. Objective of the study was to assess the knowledge, attitude and practice towards acne vulgaris among acne patients attending skin outpatient department in a private medical college.Methods: This is a cross sectional, questionnaire based study conducted between January - April 2016. 100 patients having acne lesions were included in the study.Results: Majority of the study subjects belonged to the age group 15-24. The study showed that 72% had good knowledge. More than half of the study subjects had wrong belief that eating oily foods, chocolates, spicy food caused acne but more than 40% of the study subjects had good knowledge about the causes and aggravating factors like it worsens by squeezing/picking/rubbing (83%), commonly found in oily skin (67%), has seasonal occurrence (54%), associated with premenstrual flare (42%), aggravated with use of cosmetics (41%). Conclusions: The acne patients had poor practice and unfavorable attitude in spite of good knowledge. Many myths exist among patients. Despite being so common and very well responsive to treatment, it is a major cause of depression among patients.

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“…Retinoids play key roles in skin and hair biology (20), and excess retinoids induce epidermal hyperplasia, inhibit sebocyte proliferation and differentiation, and alter hair growth (21). Notably, the skin manifestations of Dgat1 Ϫ/Ϫ mice, which include alopecia and sebaceous gland atrophy (18), resemble those of retinoid toxicity (22,23). Thus, we hypothesized that DGAT1 functions as an ARAT in murine skin and that the absence of DGAT1 alters retinoid homeostasis.…”

mentioning

confidence: 99%

Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

Shih

Kane

Zhou

et al. 2009

Journal of Biological Chemistry

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Retinoic acid (RA) is a potent signaling molecule that is essential for many biological processes, and its levels are tightly regulated by mechanisms that are only partially understood. The synthesis of RA from its precursor retinol (vitamin A) is an important regulatory mechanism. Therefore, the esterification of retinol with fatty acyl moieties to generate retinyl esters, the main storage form of retinol, may also regulate RA levels. Here we show that the neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) functions as the major acyl-CoA:retinol acyltransferase (ARAT) in murine skin. When dietary retinol is abundant, DGAT1 deficiency results in elevated levels of RA in skin and cyclical hair loss; both are prevented by dietary retinol deprivation. Further, DGAT1-deficient skin exhibits enhanced sensitivity to topically administered retinol. Deletion of the enzyme specifically in the epidermis causes alopecia, indicating that the regulation of RA homeostasis by DGAT1 is autonomous in the epidermis. These findings show that DGAT1 functions as an ARAT in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity. Our findings may have implications for human skin or hair disorders treated with agents that modulate RA signaling.

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Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

Cited by 37 publications

References 71 publications

Androgenic Hormone Profile of Adult Women with Acne

Androgenic Hormone Profile of Adult Women with Acne

Knowledge, attitude and practice towards acne vulgaris among acne patients

Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

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