Pharmacokinetics study of hemin in rats by applying 58Fe-extrinsically labeling techniques in combination with ICP-MS method

Zhao, Di; Zhang, Yongjie; Xu, Chunlin; Dong, Can; Li, Cuiyun; Ren, Shuangxia; Zhang, Wei; Yang, Lu; Dai, Yue; Chen, Xijing

doi:10.1016/j.jpba.2013.08.048

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…The Gd content was analyzed with ICP-MS (Agilent 7500C, Agilent Technologies, Tokyo, Japan) [ 47 ]. The sample introduction system consisted of a robust Babington nebulizer with a Scott spray chamber (Agilent Technologies, Tokyo, Japan) cooled by a Peltier element (2 °C).…”

Section: Methodsmentioning

confidence: 99%

Synergetic Enhancement of Tumor Double-Targeted MRI Nano-Probe

Yabbarov

Nikolskaya

Sokół

et al. 2022

IJMS

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The conventional targeted delivery of chemotherapeutic and diagnostic agents utilizing nanocarriers is a promising approach for cancer theranostics. Unfortunately, this approach often faces hindered tumor access that decreases the therapeutic index and limits the further clinical translation of a developing drug. Here, we demonstrated a strategy of simultaneously double-targeting the drug to two distinct cites of tumor tissue: the tumor endothelium and cell surface receptors. We used fourth-generation polyamideamine dendrimers modified with a chelated Gd and functionalized with selectin ligand and alpha-fetoprotein receptor-binding peptide. According to the proposed strategy, IELLQAR peptide promotes the conjugate recruitment to the tumor inflammatory microenvironment and enhances extravasation through the interaction of nanodevice with P- and E-selectins expressed by endothelial cells. The second target moiety—alpha-fetoprotein receptor-binding peptide—enhances drug internalization into cancer cells and the intratumoral retention of the conjugate. The final conjugate contained 18 chelated Gd ions per dendrimer, characterized with a 32 nm size and a negative surface charge of around 18 mV. In vitro contrasting properties were comparable with commercially available Gd-chelate: r1 relaxivity was 3.39 for Magnevist and 3.11 for conjugate; r2 relaxivity was 5.12 for Magnevist and 4.81 for conjugate. By utilizing this dual targeting strategy, we demonstrated the increment of intratumoral accumulation, and a remarkable enhancement of antitumor effect, resulting in high-level synergy compared to monotargeted conjugates. In summary, the proposed strategy utilizing tumor tissue double-targeting may contribute to an enhancement in drug and diagnostic accumulation in aggressive tumors.

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Section: Methodsmentioning

confidence: 99%

Synergetic Enhancement of Tumor Double-Targeted MRI Nano-Probe

Yabbarov

Nikolskaya

Sokół

et al. 2022

IJMS

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“…These types of metabolic studies are clearly facilitated using several tracers. Other recent applications of elemental tracers in metabolic and metallomics studies include zinc, 73 iron 74 and selenium. 75 Other applications are reviewed elsewhere.…”

Section: Applications Of Isotopic Measurementsmentioning

confidence: 99%

“…69 The central peak in the chromatogram at mass 80 represents the selenosugar. The tracer used here was 74 Se; it was added post-column at a constant ow rate throughout the chromatographic process. A small negative peak observed in the dead volume of the chromatographic system was due to the elution of the matrix components from the sample.…”

Section: Total Elemental Analysis By Idmsmentioning

confidence: 99%

Isotopic measurements using ICP-MS: a tutorial review

Penanes

Reguera-Galan

Huelga-Suarez

et al. 2022

J. Anal. At. Spectrom.

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“…The MeP and MeP-NPs pharmacokinetics study was accomplished using randomly divided rat groups (n = 3). Blood samples (50 µL) were collected before injection and after at different time points: 0.25, 0.50, 1.0, 3.0, 6.0, 24.0, and 48.0 h. The blood samples were diluted to 1.0 mL and analyzed with ICP-MS (Agilent 7500C, Agilent Technologies, Tokyo, Japan) [112]. The sample introduction system consisted of a robust Babington nebulizer with a Scott spray chamber (Agilent Technologies, Tokyo, Japan) cooled by a Peltier element (2 • C).…”

Section: In Vivo Pharmacokinetic Studymentioning

confidence: 99%

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Mollaeva

Yabbarov

Sokół

et al. 2021

IJMS

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The selection of technological parameters for nanoparticle formulation represents a complicated development phase. Therefore, the statistical analysis based on Box–Behnken methodology is widely used to optimize technological processes, including poly(lactic-co-glycolic acid) nanoparticle formulation. In this study, we applied a two-level three-factor design to optimize the preparation of nanoparticles loaded with cobalt (CoTPP), manganese (MnClTPP), and nickel (NiTPP) metalloporphyrins (MeP). The resulting nanoparticles were examined by dynamic light scattering, X-ray diffraction, Fourier transform infrared spectroscopy, MTT test, and hemolytic activity assay. The optimized model of nanoparticle formulation was validated, and the obtained nanoparticles possessed a spherical shape and physicochemical characteristics enabling them to deliver MeP in cancer cells. In vitro hemolysis assay revealed high safety of the formulated MeP-loaded nanoparticles. The MeP release demonstrated a biphasic profile and release mechanism via Fick diffusion, according to release exponent values. Formulated MeP-loaded nanoparticles revealed significant antitumor activity and ability to generate reactive oxygen species. MnClTPP- and CoTPP-nanoparticles specifically accumulated in tissues, preventing wide tissue distribution caused by long-term circulation of the hydrophobic drug. Our results suggest that MnClTPP- and CoTPP-nanoparticles represent the greatest potential for utilization in in anticancer therapy due to their effectiveness and safety.

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Pharmacokinetics study of hemin in rats by applying 58Fe-extrinsically labeling techniques in combination with ICP-MS method

Cited by 9 publications

References 27 publications

Synergetic Enhancement of Tumor Double-Targeted MRI Nano-Probe

Synergetic Enhancement of Tumor Double-Targeted MRI Nano-Probe

Isotopic measurements using ICP-MS: a tutorial review

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

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