Pharmacokinetics study of 16 representative components from Baoyuan Decoction in rat plasma by LC–MS/MS with a large-volume direct injection method

Lu, Yingyuan; Chen, Jinfeng; Song, Jinyang; Du, Zhiyong; Wang, Jinlong; Qian, Yi; Jiang, Yong; Guo, Xiaoyu; Tu, Peng‐Fei

doi:10.1016/j.phymed.2018.09.002

Cited by 23 publications

(11 citation statements)

References 39 publications

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“…Clearly, the sensitivity was amplified significantly with fewer detected ions within one segment. This phenomenon could be explained by that the number of ions monitored in the same time could be reduced and the dwell time was prolonged in sMRM [23,24].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics study of 16 active ingredients from Tabson‐2 decoction in normal and d‐galactose induced osteoporosis rats by liquid chromatography–tandem mass spectrometry

Dong

et al. 2020

J of Separation Science

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Tabson‐2 decoction is the traditional Mongolian formula for anti‐osteoporosis, and the ambiguous of active ingredient is an important factor in restricting its modernization and globalization. Although pharmacokinetic profiles research is a viable approach to find the components being responsible for formula efficacy, the pharmacokinetics study of Tabson‐2 decoction has not been elucidated yet. Owing to the existence of isomers, low bioavailability of some small molecule and interference of endogenous, the pharmacokinetics study of Tabson‐2 decoction are more difficult than that of chemical drugs. In our experiment, a specific and sensitive liquid chromatography–tandem mass spectrometry method was developed and validated for simultaneous determination of 16 active ingredients in Tabson‐2 decoction, which could fulfill the requirements of multi‐compounds pharmacokinetic study of Tabson‐2 decoction. Additionally, the ingredients with significant distributions in rats were gentianic acid, chlorogenic acid, and aucubin, which could be the main potential active components in Tabson‐2 decoction. The components with a significant bioavailability difference between normal and d‐galactose induced osteoporosis rats were achieved as well. These data offer useful information for screening the active ingredients in Tabson‐2 decoction, and assessing the bioavailability of these active ingredients in different physiological status, which might provide a possible mechanism of anti‐osteoporosis efficacy of Tabson‐2 decoction.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics study of 16 active ingredients from Tabson‐2 decoction in normal and d‐galactose induced osteoporosis rats by liquid chromatography–tandem mass spectrometry

Dong

et al. 2020

J of Separation Science

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“…A pharmacokinetic study of flavonoid or chalcone aglycones and saponins in rats gives insight into the differences of absorption from the GIT between these two types of compound. Relatively apolar compounds, with fewer hydrogen donor and acceptor groups, reach peak plasma concentration in 5–30 min (Ying-Yuan et al, 2019). A similar outcome was observed with monoglycosides.…”

Section: The Pharmacokinetic Journey: From Petri Dish To the Site Of mentioning

confidence: 99%

From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products

Sadgrove

Jones

2019

Front. Microbiol.

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The new era of multidrug resistance of pathogens against frontline antibiotics has compromised the immense therapeutic gains of the ‘golden age,’ stimulating a resurgence in antimicrobial research focused on antimicrobial and immunomodulatory components of botanical, fungal or microbial origin. While much valuable information has been amassed on the potency of crude extracts and, indeed, purified compounds there are too many reports that uncritically extrapolate observed in vitro activity to presumed ingestive and/or topical therapeutic value, particularly in the discipline of ethnopharmacology. Thus, natural product researchers would benefit from a basic pharmacokinetic and pharmacodynamic understanding. Furthermore, therapeutic success of complex mixtures or single components derived therefrom is not always proportionate to their MIC values, since immunomodulation can be the dominant mechanism of action. Researchers often fail to acknowledge this, particularly when ‘null’ activity is observed. In this review we introduce the most up to date theories of oral and topical bioavailability including the metabolic processes affecting xenobiotic biotransformation before and after drugs reach the site of their action in the body. We briefly examine the common methodologies employed in antimicrobial, immunomodulatory and pharmacokinetic research. Importantly, we emphasize the contribution of synergies and/or antagonisms in complex mixtures as they affect absorptive processes in the body and sometimes potentiate activity. Strictly in the context of natural product research, it is important to acknowledge the potential for chemotypic variation within important medicinal plants. Furthermore, polar head space and rotatable bonds give a priori indications of the likelihood of bioavailability of active metabolites. Considering this and other relatively simple chemical insights, we hope to provide the basis for a more rigorous scientific assessment, enabling researchers to predict the likelihood that observed in vitro anti-infective activity will translate to in vivo outcomes in a therapeutic context. We give worked examples of tentative pharmacokinetic assessment of some well-known medicinal plants.

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“…The PK research of the multiple types of compounds in SSW and its "Herb Pairs" to normal and colitis rats remains the first time. A selective and reliable UHPLC-MS/MS method was established using multiple reaction monitoring (MRM) mode, which was increasingly wide application for the multiple and complex compounds quantitation in trace amounts [26][27][28]. The research conducted on the pathological model rats would be more reasonable, for the situation was more linked to the clinical application of SSW.…”

Section: Introductionmentioning

confidence: 99%

Poly‐pharmacokinetic strategy represented the synergy effects of bioactive compounds in a traditional Chinese medicine formula, Si Shen Wan and its separated recipes to normal and colitis rats

Liu

Wang

et al. 2021

J of Separation Science

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is a classic traditional Chinese medicine formula, which has been used to treat chronic colitis for thousands of years. Many research and experience show that Si Shen Wan was developed by the combination of two sets of "Herb Pairs," Er Shen Wan and Fructus Schisandrae Chinensis Powder. This research aimed to revealing the effective substances, guide the clinical treatment, and represent the synergy effects from the view of pharmacokinetics. An ultra high performance liquid chromatography with tandem mass spectrometry method was established and validated for simultaneous quantification of 26 main bioactive compounds in normal and colitis rat plasma after oral administration of Si Shen Wan and its "Herb Pairs" extract. The method validation results illustrated that the experimental method was reliable and reproducible for quantitative determination of the biological samples. The pharmacokinetic behaviors in different groups were compared and discussed comprehensively, which indicated that the treatment of Si Shen Wan has a superiority in synthetic action of the "Herb Pairs" for the higher peak concentrations and bioavailability of some mainly components. Furthermore, the synergy effect was still existing backed up again for the longer eliminate time and a better bioavailability in colitis groups. The pharmacokinetics research of multiple components in Si Shen Wan and its "Herb Pairs" supplied a significant basis for better understanding the metabolic mechanism of these formulas in both normal and pathological state.

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Pharmacokinetics study of 16 representative components from Baoyuan Decoction in rat plasma by LC–MS/MS with a large-volume direct injection method

Cited by 23 publications

References 39 publications

Pharmacokinetics study of 16 active ingredients from Tabson‐2 decoction in normal and d‐galactose induced osteoporosis rats by liquid chromatography–tandem mass spectrometry

Pharmacokinetics study of 16 active ingredients from Tabson‐2 decoction in normal and d‐galactose induced osteoporosis rats by liquid chromatography–tandem mass spectrometry

From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products

Poly‐pharmacokinetic strategy represented the synergy effects of bioactive compounds in a traditional Chinese medicine formula, Si Shen Wan and its separated recipes to normal and colitis rats

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