Pharmacokinetics of tinidazole in cows‐a preliminary study

Pyörälä, Satu; Silvennoinen, P.; Hänninen, U.; Mero, M.

doi:10.1111/j.1365-2885.1990.tb00798.x

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…Tinidazole and other nitroimidazole derivatives are active against a wide range of anaerobes, as also demonstrated here. Among nitroimidazoles, the pharmacokinetics of tinidazole has been studied in several animal species, including lactating cows (19). This is a good example of a drug with highly variable pharmacokinetics in different animal species.…”

Section: Discussionmentioning

confidence: 99%

Susceptibilities of bovine summer mastitis bacteria to antimicrobial agents

Jousimies‐Somer

Pyörälä

Kanervo

1996

Antimicrob Agents Chemother

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The susceptibility to 9 antimicrobial agents of 32 aerobic bacterial isolates and to 10 antimicrobial agents of 37 anaerobic bacterial isolates from 23 cases of bovine summer mastitis (16 Actinomyces pyogenes isolates, 8 Streptococcus dysgalactiae isolates, 3 S. uberis isolates, 3 S. acidominimus isolates, 2 Streptococcus spp., 15 Peptostreptococcus indolicus isolates, 10 Fusobacterium necrophorum isolates, and 12 isolates of anaerobic gram-negative rods) was determined by the agar dilution method. All isolates except one Bacteroides fragilis isolate (beta-lactamase producer) were susceptible to penicillin G, amoxicillin, amoxicillin-clavulanate, cefoxitin, clindamycin, and chloramphenicol (the B. fragilis strain was susceptible to the last four), which had MICs at which 90% of isolates were inhibited (MIC90s) of < or = 0.06, < or = 0.06, < or = 0.06 0.25, < or = 0.06, and 4.0 micrograms/ml, respectively. Spiramycin was active against the gram-positive aerobes (MIC90, 1.0 microgram/ml) but not against the anaerobes (MIC90, 16.0 micrograms/ml). Similar trends were noted for susceptibilities of aerobic and anaerobic bacteria to ofloxacin (MIC90s, 2.0 and 8 micrograms/ml, respectively). Occasional strains of aerobic streptococci were resistant to oxytetracycline, but all anaerobes were susceptible. Tinidazole was active against all anaerobes (MIC90, 2.0 micrograms/ml). beta-Lactamase was produced only by the B. fragilis isolate.

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Section: Discussionmentioning

confidence: 99%

Susceptibilities of bovine summer mastitis bacteria to antimicrobial agents

Jousimies‐Somer

Pyörälä

Kanervo

1996

Antimicrob Agents Chemother

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Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice

Minvielle¹,

Basualdo²,

Ciarmela³

et al. 1999

Parasitology Research

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The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3-5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.

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