Pharmacokinetics of Theophylline in Children With Asthma

Ellis, Elliot F.; Koysooko, Renu; Levy, Gerhard

doi:10.1542/peds.58.4.542

Cited by 216 publications

(2 citation statements)

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“…The low trough and peak STL in our study probably reflects a lower dosage schedule (14 mg/kg/day) than used by some other workers 13 , 14 . In addition, this could well be due to an interindividual and day‐to‐day variation in absorption and clearance of theophylline 15 . However, the mean variation between the dosage was only 3.06 μ g/ml, showing a fairly even plasma concentration during the 24‐hour period.…”

Section: Discussioncontrasting

confidence: 54%

Slow release aminophylline in long term management of chronic childhood asthma

Bose

1987

Int J Clinical Practice

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Section: Discussioncontrasting

confidence: 54%

Slow release aminophylline in long term management of chronic childhood asthma

Bose

1987

Int J Clinical Practice

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“…Oral theophylline preparations have a well established role in the management of adult and childhood asthma 1 , 2 , 3 . Because of the short half‐life of plain theophylline, frequent six‐hourly doses are required to maintain therapeutic blood levels 4 . Rapid absorption from the gastrointestinal tract leads to large swings in plasma theophylline levels and, as a result, the initial high peak values are often associated with unacceptable side effects 5 .…”

Section: Introductionmentioning

confidence: 99%

Slow release theophylline in chronic bronchitis — a comparative study*

Evans¹

1986

Int J Clinical Practice

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Reliability of Salivary Theophylline as a Guide to Plasma Theophylline Levels

Galant¹,

Gillman²,

Cummins³

et al. 1977

Arch Pediatr Adolesc Med

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\s=b\Simultaneous saliva and plasma theophylline levels in 12 chronic asthmatic children were measured by high pressure liquid chromatography following administration of a theophylline preparation. In five subjects, simultaneous plasma and salivary theophylline were measured one week later. A strongly positive correlation between plasma and salivary theophylline levels was found at all time periods tested.There was no substantial difference in the plasma-saliva theophylline ratio determined one week later. A predicted plasma Recent studies on drug therapy of ' patients with bronchial asthma have suggested the use of higher doses of theophylline than those previously recommended.1 In using such high doses, it is desirable to monitor the plasma concentration to indicate whether either therapeutic or potentially toxic levels have been reached.2 Pharmacokinetic studies in asthmatic patients show considerable variability in the plasma half-life of theophylline,3 with a range of 1.42 to 7.85 hours in children.4 Therefore, an appropriate dosage program for one patient may not be suitable for another. Determination of plasma levels at various time periods followFrom the Department of Pediatrics, University of California at Irvine. Reprints are not available.level was compared with the observed value. The proportionality of predicted to observed plasma theophylline levels using either the entire study group mean plasma-saliva ratio or each individual's ratio was approximately 1.00 with 9% variability. When a previously reported plasma-saliva theophylline ratio was used for comparison, the predicted plasma theophylline was 15% above the observed plasma level. (Am J Dis Child 131: [970][971][972] 1977) ing drug administration could estab¬ lish the high and low values and the rapidity of clearance (half-life) from the plasma. This would have great relevance in determining the proper dose. The obvious objection, particu¬ larly in the pediatrie age patient, is the discomfort and inconvenience of the multiple blood samples required. Koysooko et al5 found that a constant ratio existed between simul¬ taneously obtained plasma and saliva theophylline concentrations in normal adults. In a subsequent study involv¬ ing asthmatic children, these investi¬ gators were able to predict the plasma theophylline levels within 20% of the actual values by multiplying the mea¬ sured saliva theophylline level by the previously established plasma/saliva ratio." However, one recent report failed to confirm the consistency of this ratio.7 In the present study, we report the hourly variability of the plasma-saliva ratio, as well as the week-to-week consistency of the ratio, in the same patient. We also have compared the accuracy of predicting plasma theophylline levels using each individual's plasma-saliva ratio, the mean ratio of our entire group, and the mean ratio for the asthmatic patients reported in the literature." SUBJECTS AND METHODSTwelve asthmatic children (aged 6 to 14 years) were given 3.0 to 8.1 mg/kg of anhydrous theophylline every...

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Pharmacokinetics of Theophylline in Children With Asthma

Cited by 216 publications

References 0 publications

Slow release aminophylline in long term management of chronic childhood asthma

Slow release aminophylline in long term management of chronic childhood asthma

Slow release theophylline in chronic bronchitis — a comparative study*

Reliability of Salivary Theophylline as a Guide to Plasma Theophylline Levels

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