Pharmacokinetics of terbinafine and five known metabolites in children, after oral administration

Human Pharmacogenomic Variations and Their Implications for Antifungal Efficacy

“…A significant negative correlation between the mean blood concentration of ketoconazole and age has been reported (185). Terbinafine AUC values are significantly higher in children than in young adults (194), although in a separate study, higher plasma concentrations and lower half-lives of the terminal elimination phase were reported (127). For fluconazole, the volume of distribu-tion is greater in neonates and decreases in young adults (31), the mean plasma half-life in children (22 h) is shorter than in adults (37 h) (59), and total clearance is greater in children (1.16 liters/h) than in adults (1.07 liters/h) (163).…”

Single dose pharmacokinetics of terbinafine in cats

“…Many studies have assessed the pharmacokinetics of terbinafine following oral administration in humans. 15,16,[23][24][25] Related studies have also been carried out in animals, including African penguins and red-tailed hawks, 13,14 horses and Greyhounds. 17 However, to date, no information about the pharmacokinetics of terbinafine after IV or oral administration in cats has been reported.…”

“…The pharmacokinetics of terbinafine has been evaluated in humans, horses, dogs, penguins and hawks. 13–17 Although some studies on the determination of terbinafine in cat plasma and hair have been described, 18–20 little is known about the pharmacokinetics of terbinafine in cats. Given the use of terbinafine in cats, the purposes of this study were to assess the pharmacokinetics of terbinafine in cats after intravenous (IV) and oral administration, and to determine the oral bioavailability of terbinafine hydrochloride tablets.…”

An integrated One Health framework for holistic evaluation of risks from antifungal agents in a large-scale multi-city study using post-acquisition mass spectral data mining and wastewater-based epidemiology pipelines

“…Moreover, there was no information found in literature on prochloraz, propiconazole and terbinafine excretion in urine or faces. (Fustinoni et al, 2014;Oerlemans et al, 2019) Terbinafine ---urine (human) No unchanged terbinafine was excreted in the urine (Jensen, 2009) N-desmethylcarboxyterbinafine 53.8 1.98 urine (human) (Humbert et al, 1998) Voriconazole Voriconazole 2.0 50.0 urine (human) (Levêque et al, 2006) WBE AF intake (PNDI) estimates as well as AF per-capita NHS per-postcode prescription (PNDP) are presented in Figures 7 and 8. Average WBE-estimated fluconazole PNDIs were 330 ± 125, 627 ± 1231, 309 ± 12, 163 ± 40 and 8 ± 2 mg day -1 1000inh -1 , and prescription PNDPs were 33, 6, 18, 19, and 12 mg day -1 1000inh -1 for city A, B, C and D. Similarly, average WBE-estimated ketoconazole PNDIs were 3001 ± 891 and 2145 ± 682 mg day -1 1000inh -1 , and prescription PNDPs were 74 and 69 mg day -1 1000inh -1 for city B and D. It is apparent that PNDIs are much higher than PNDPs.…”