Pharmacokinetics of sulphamonomethoxine and sulphadimethoxine following oral administration to cultured rainbow trout (Oncorhynchus mykiss)

Uno, Kazuaki; Aoki, Takahiko; Ueno, Ryuji

doi:10.1016/0044-8486(93)90137-n

Cited by 35 publications

(24 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…and PO groups, respectively. As opposed to the findings of Uno et al (1993), depletion of the N4-acetyl metabolite in gilthead sea bream was even faster than the parent substance, reaching levels below LOQ 24 h after treatment termination in both groups. In other species such as Atlantic cod, N4-acetylation of SDM was considered to be a metabolic pathway with moderate importance while edible tissues were not sampled (Samuelsen, 2006).…”

Section: Discussioncontrasting

confidence: 43%

“…Specifically, a significant increase in acetylation and a decrease in hydroxylation of SDM were observed in common carp plasma with increasing temperature . Interestingly, the N4-acetyl metabolite of sulfonamides may stay longer than the parent compounds in the tissues of treated fish with the possibility to convert back to the parent drug via a deacetylation process (Uno et al, 1993). It is still unknown whether the processes of sulfonamide acetylation and deacetylation are related to the same or different enzymatic systems.…”

Section: Discussionmentioning

confidence: 99%

“…N4-acetylation has been reported as the major metabolic route in fish (Squibb et al, 1988;Uno et al, 1993;Samuelsen et al, 1995). Water temperature appeared to affect the metabolic processes of sulfonamides in fish.…”

Section: Discussionmentioning

confidence: 99%

“…In other species such as Atlantic cod, N4-acetylation of SDM was considered to be a metabolic pathway with moderate importance while edible tissues were not sampled (Samuelsen, 2006). N4-acetylation however appeared to be a major part of SDM metabolism in Atlantic salmon (Samuelsen et al, 1995;, channel catfish (Squibb et al, 1988) and rainbow trout (Uno et al, 1993). For example, the sulfonamide derivatives accounted for 29-37% of the parent compounds in fish muscle at 24 h post-dosing in the most recent study by Uno et al (1993).…”

Section: Discussionmentioning

confidence: 99%

“…Metabolism of sulfonamides under N4-acetylation, hydroxylation and glucuronidation occurs in animals including fish (Grondel et al, 1986;Squibb et al, 1988;Ishida, 1989;van Ginneken et al, 1991;Kleinow et al, 1992;Nouws et al, 1993;Uno et al, 1993;Zheng et al, 1994;Samuelsen et al, 1995Samuelsen et al, , 1997Samuelsen, 2006). N4-acetylation has been reported as the major metabolic route in fish (Squibb et al, 1988;Uno et al, 1993;Samuelsen et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Distribution and depletion of sulfadiazine after a multiple per os dosing in gilthead sea bream (Sparus aurata) fed two different diets

et al. 2013

View full text Add to dashboard Cite

The distribution and depletion profile of sulfadiazine (SDZ) were investigated in gilthead sea bream (Sparus aurata) fed on fish oil (FO) or plant oil-based (PO) diets. Fish averaging 230 g were given medicated feed containing 25 mg SDZ kg-1 fish for 5 days at 24-26oC. Blood and muscle plus skin were sampled on days 1, 3, 5, 6, 8 and 9. Differences in plasma and fillet SDZ levels between the two groups were statistically insignificant. The maximum drug concentrations in plasma were 3.2 ± 1.9 μg mL-1 and 2.9 ± 1.2 μg mL-1 in the PO and FO groups, respectively. In post-medicated samples depletion rapidly reached concentrations close to the level of quantification at 72 h post medication. Withdrawal times to reach consumer safety levels were calculated to be 103 and 118 h for the FO and the PO groups, respectively. N4-acetylation was found to be the major metabolic pathway of SDZ in gilthead sea bream fillet accounting for 23 and 19% of the parent compound in the FO and the PO groups, respectively. Overall, alteration of the dietary lipid profile induced insignificant effects on the kinetics of SDZ. The high tissue SDZ levels during medication and the fast removal of the parent compound and its metabolites from edible tissues of gilthead sea bream reflect a promising antibacterial profile.

show abstract

Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Distribution and depletion of sulfadiazine after a multiple per os dosing in gilthead sea bream (Sparus aurata) fed two different diets

et al. 2013

View full text Add to dashboard Cite

show abstract

Problems faced when evaluating the bioaccumulation potential of substances under REACH

Ehrlich

Jöhncke

Drost

et al. 2011

Integr Environ Assess Manag

View full text Add to dashboard Cite

The identification and regulation of substances that combine persistence, bioaccumulation potential, and toxicity ("PBT" substances) is one central aspect of the European chemical legislation REACH (Registration, Evaluation, Authorisation, and Restriction of Chemicals), because these substances may elicit adverse long-term effects after release to the environment. The determination of a substance that has persistence, bioaccumulation potential, and toxicity is based on a set of distinct cutoff criteria identified in Annex XIII of the REACH regulation. Regarding the bioaccumulation potential, the evaluation is focused on the substance's bioconcentration factor as single decisive criterion. In addition, the REACH guidelines provide a selection of standardized test procedures for measuring bioconcentration factor and guidance in appraising test results. However, alternative test results like bioaccumulation factors and biomagnification as well as additional indications for a bioaccumulation potential such as trophic magnification are only allowed for supporting evidence. The currently used test systems with aquatic exposure have been demonstrated to generate reliable results for the majority of neutral, lipophilic organic substances, which facilitate clear decision-making by means of the crucial bioconcentration factor cutoff criteria of Annex XIII. However, certain substance groups such as highly hydrophobic organic substances and amphiphilic and nonlipophilic compounds are difficult to evaluate with common test strategies due to inappropriate test systems or accumulation mechanisms not based on lipophilicity. Recent scientific progress has already been made to establish alternative test systems and to refine the bioaccumulation assessment by consideration of additive accumulation mechanisms and indications. This article gives an overview on actual shortcomings in the current bioaccumulation assessment under REACH and also provides suggestions for a refinement of evaluation.

show abstract

Metabolism and Pharmacokinetics of Sulfamonomethoxine in Edible Fish Species

Ueno

1999

Xenobiotics in Fish

View full text Add to dashboard Cite

Pharmacokinetics of sulphamonomethoxine and sulphadimethoxine following oral administration to cultured rainbow trout (Oncorhynchus mykiss)

Cited by 35 publications

References 17 publications

Distribution and depletion of sulfadiazine after a multiple per os dosing in gilthead sea bream (Sparus aurata) fed two different diets

Distribution and depletion of sulfadiazine after a multiple per os dosing in gilthead sea bream (Sparus aurata) fed two different diets

Problems faced when evaluating the bioaccumulation potential of substances under REACH

Metabolism and Pharmacokinetics of Sulfamonomethoxine in Edible Fish Species

Contact Info

Product

Resources

About