Pharmacokinetics of sulphadimidine in carp (<i>Cyprinus carpio</i>L.) and rainbow trout (<i>Salmo gairdneri</i>Richardson) acclimated at two different temperature levels

Vj, van Ginneken; Jf, Nouws; Jl, Grondel; Driessens, F. C. M.; Degen, Michael

doi:10.1080/01652176.1991.9694290

Cited by 28 publications

(10 citation statements)

References 28 publications

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“…Conversely, at colder acclimation temperatures less metabolites are present and compound t½s are longer. This is consistent with numerous temperature studies examining a variety of pharmaceuticals and other xenobiotics (Collier et al 1978; Varanasi et al 1981; Salte and Liestol 1983; Kasuga et al 1984; Jacobsen 1989; van Ginneken et al 1991; Bjorklund et al 1992; Kleinow et al 1994). While these in vivo findings suggest that warmer temperatures result in greater biotransformation and subsequent elimination, in vitro studies with membrane-bound systems suggest activity compensation with temperature change.…”

Section: Temperature Alters Xenobiotic Elimination In Fishsupporting

confidence: 88%

Seasonal influences on PCB retention and biotransformation in fish

James

Kleinow

2013

Environ Sci Pollut Res

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There is extensive evidence that fish from waters with PCB-contaminated sediments accumulate PCBs and related chemicals, and that people who eat fish from contaminated waters have higher body burdens of PCBs and PCB metabolites than those who do not. PCBs and their metabolites are potentially toxic, thus it is important to human health to understand the uptake, biotransformation and elimination of PCBs in fish, since these processes determine the extent of accumulation. The intestinal uptake of PCBs present in the diet of fish into fish tissues is a process that is influenced by the lipid composition of the diet. Biotransformation of PCBs in fish, as in mammals, facilitates elimination, although many PCB congeners are recalcitrant to biotransformation in fish and mammals. Sequential biotransformation of PCBs by cytochrome P450 and conjugation pathways is even less efficient in fish than in mammalian species, thus contributing to the retention of PCBs in fish tissues. A very important factor influencing overall PCB disposition in fish is water temperature. Seasonal changes in water temperature produce adaptive physiological and biochemical changes in fish. While uptake of PCBs from the diet is similar in fish acclimated to winter or summer temperatures, there is evidence that elimination of PCBs occurs much more slowly when the fish is acclimated at low temperatures than at warmer temperatures. Research to date suggests that the processes of elimination of PCBs are modulated by several factors in fish including seasonal changes in water temperature. Thus, the body burden of PCBs in fish from a contaminated location is likely to vary with season.

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Section: Temperature Alters Xenobiotic Elimination In Fishsupporting

confidence: 88%

Seasonal influences on PCB retention and biotransformation in fish

James

Kleinow

2013

Environ Sci Pollut Res

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“…The T max of CFQ in turtles ( 3 hr) was longer than those in tilapia (0.14 and 0.17 hr) after IM and IP administrations of CFQ (10 mg/kg) at 30°C (Shan et al., ), but shorter than that in Coho salmon (12 hr) after IP administration of CFQ (20 mg/kg) at 10°C (San Martín et al., ). Different T max values may be related to differences in cardiac rate and tissue blood flow resulting from species difference and temperature adaptations (Kik & Mitchell, ; Van Ginneken et al., ). The overall MRT was longer for IM injection (31.92 hr) compared with that for IV injection (24.99 hr); this was expected because the disposition and absorption rates after IM injection affect the MRT.…”

Section: Pharmacokinetic Parameters Of Cfq In Red‐eared Sliders (N = mentioning

confidence: 99%

“…CFQ is minimally metabolized and excreted predominantly by the kidneys in mammals (CVMP, 1995). Differences in the Cl T and t 1/2λz of CFQ between species are possibly the result of species differences and temperature adaptations, which affect renal clearance rates and the activity of the cardiovascular system (Kik & Mitchell, 2005;Van Ginneken, Nouws, Grondel, Driessens, & Degen, 1991).…”

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confidence: 99%

Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Üney

Altan

Gül

et al. 2017

Vet Pharm & Therapeutics

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The purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2 mg/kg body weight in red-eared slider turtles. Plasma concentrations of CFQ were determined by high-performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: , and total body clearance (Cl T ) 12.66 ± 2.51 ml hr −1 kg −1. The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (C max ) 3.94 ± 0.84 μg/ml, time to peak concentration (T max ) 3 hr, t 1/2λz26.90 ± 4.33 hr, and AUC 0-∞ 145 ± 48 μg hr −1 ml −1. The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half-life and a high bioavailability in red-eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.

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“…It is known that in turtles, systemic and pulmonary blood flows decrease during cooling and the heart rate rises up during warming (Galli, Taylor, & Wang, 2004). In reptiles and fish, cardiac output and tissue perfusion rates vary depending on the ambient temperature (Kik & Mitchell, 2005;Van Ginneken, Nouws, Grondel, Driessens, & Degen, 1991).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of marbofloxacin in Green sea turtles (Chelonia mydas) following intravenous and intramuscular administration at two dosage rates

Poapolathep

Laovechprasit²,

Giorgi

et al. 2019

Vet Pharm & Therapeutics

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Limited pharmacokinetic information to establish suitable therapeutic plans is available for green sea turtles. Therefore, the present study was conducted to evaluate the pharmacokinetic characteristics of marbofloxacin (MBF) in the green sea turtle, Chelonia mydas, following single intravenous (i.v.) or intramuscular (i.m.) administration at two dosages of 2 and 4 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 168 hr. MBF in plasma was extracted using liquid–liquid extraction and analyzed by a validated high‐performance liquid chromatography (HPLC). MBF was quantifiable from 15 min to 96 hr after i.v. and i.m. administrations at two dose rates. A noncompartmental model was used to fit the plasma concentration of MBF versus time curve for each green sea turtle. The t1/2λz value, similar for both the dosages (22–28 hr), indicated that the overall rate of elimination of MBF in green sea turtles is relatively slow. The average i.m. F% ranged 88%–103%. MBF is a concentration‐dependent drug and the AUC/MIC ratio is the best PK/PD predictor for its efficacy. The MBF dosage of 4 mg/kg appeared to produce an appropriate value of the PK‐PD surrogate that predicts antibacterial success for disease caused by susceptible bacteria. In contrast, i.m. administration of MBF at a dosage of 2 mg/kg b.w. was not found to produce a suitable PK‐PD surrogate index. However, further studies of multiple doses and plasma binding proteins are warranted to confirm an appropriate dosage regimen.

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Pharmacokinetics of sulphadimidine in carp (Cyprinus carpioL.) and rainbow trout (Salmo gairdneriRichardson) acclimated at two different temperature levels

Cited by 28 publications

References 28 publications

Seasonal influences on PCB retention and biotransformation in fish

Seasonal influences on PCB retention and biotransformation in fish

Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Pharmacokinetics of marbofloxacin in Green sea turtles (Chelonia mydas) following intravenous and intramuscular administration at two dosage rates

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