Pharmacokinetics of subcutaneously administered doramectin in alpacas

Abstract

The objective of this research was to evaluate comparative pharmacokinetics of doramectin in alpacas, after subcutaneous administration of 0.2 mg/kg dose. Six healthy adult alpacas, mean age of 5 years ± 1, (three female and three gelded males) of mean bodyweight of 62 kg ± 16 kg with an average body condition scored 2.8 ± 1 out of five, were used in this study. Serial blood samples were collected from the jugular vein before the administration until day 21 afterwards to establish the pharmacokinetics of doramectin after its subcutaneous administration at 0.2 mg/kg dose. The blood samples were analysed using high‐performance liquid chromatography (HPLC), fluorescence detection method with precolumn derivatisation, validated for alpacas. The pharmacokinetic parameters were calculated using a noncompartmental model, and results showed Cmax (6.05 ± 5.34 ng/ml), Tmax (3.83 ± 2.48 days), AUC (62.12 ± 18.86 ng/ml × d), terminal half‐life (6.2 ± 4.9 days) and MRT (11.56 ± 4.43 days). The results of this study showed that the Cmax and AUC were much lower than in cattle and sheep at the same dosage. Tmax remained similar to cattle and sheep. This study presents valuable information about pharmacokinetics of doramectin in alpacas, which can be utilised in its future efficacy studies.

Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice

“…(18), while the SD of the AUC was calculated using Yuan's method (19) to compare the AUC of the OTC and OTC-CNP groups. Clearance (CL/F) and the apparent volume of the distribution (V d /F) were calculated using the formula: (dose)/AUC (0−∞) and (dose)/(λ z × AUC (0−∞) ), respectively (20).…”

Improved Fermentation Yield of Doramectin from Streptomyces avermitilis N72 by Strain Selection and Glucose Supplementation Strategies

“…Doramectin does not easily cross the blood-brain barrier, and is safe for the treatment of parasitic diseases in mammals as it causes minimal damage to the central nervous system. It is used for the treatment of parasites in horses, cattle, sheep, pigs, and dogs [4][5][6][7]. It has a wider antiparasitic range and higher efficacy than avermectin [8,9], ivermectin [10,11] and other avermectin-based drugs [12,13].…”