Pharmacokinetics of propofol during conscious sedation using target-controlled infusion

Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a Taiwanese population

“…TCI is a novel approach to sedation that integrates continuous physiological monitoring with the delivery of propofol through a computer interface to facilitate a precise control of the level of sedation. 8,20,21 Previous studies have shown that TCI had application in ERCP and EUS. In a pilot study including 20 patients undergoing ERCP, Gillham et al 9 assessed patient-controlled sedation with a TCI of propofol, with the sedation being considered generally adequate, but in 15% of the cases the system failed because of the low maximum target concentration allowed (3 mg/mL).…”

“…The potential advantage of TCI method compared with continuous infusion (with a fixed dose and infusion rate) is its ability to avoid the accumulation of the drug, since the infusion rate is constantly being changed. TCI is a novel approach to sedation that integrates continuous physiological monitoring with the delivery of propofol through a computer interface to facilitate a precise control of the level of sedation …”