Pharmacokinetics of oxolinic acid and Oxytetracycline in kuruma shrimp, Penaeus japonicus

Uno, Kazuaki

doi:10.1016/j.aquaculture.2003.10.007

Cited by 37 publications

(52 citation statements)

References 33 publications

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“…The program used a compartmental open model based on non-linear regression analysis to analyze the concentration-time data for plasma. Following oral administration, the bioavailability ( F ) was calculated according to the equation: F (%) = AUC PO /AUC IV ×100% (Kazuaki, 2004;Abo-El-Sooud and Goudah, 2009). …”

Section: Pharmacokinetic Analysismentioning

confidence: 99%

Pharmacokinetics and tissue behavior of enrofloxacin and its metabolite ciprofloxacin in turbot Scophthalmus maximus at two water temperatures

Liang

Zhao

et al. 2012

Chin. J. Ocean. Limnol.

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Turbot Scophthalmus maximus , an important aquaculture species in China, currently suffers from epizootic diseases because of high density aquaculture. Enrofl oxacin has been used to treat various systemic bacterial fi sh infections. However, studies concerning the pharmacokinetics of enrofl oxacin in turbot are limited. In this study, the pharmacokinetics of enrofl oxacin and its metabolite ciprofl oxacin, were investigated in the turbot following intravenous and oral administration at 10 mg enrofl oxacin/kg body weight, at 16°C and 10°C water temperatures. The concentrations of enrofl oxacin and ciprofl oxacin in the main tissues (plasma, muscle, liver and kidney) were detected by HPLC. The results show that the plasma concentration-time data for enrofl oxacin were best described as a two-compartment open model after intravenous and oral administration. Three pharmacokinetic equations were established between the concentrations and temperatures. The kinetic profi le of enrofl oxacin was temperature dependent. The absorption half-life of enrofl oxacin was 1.99 h and 2.17 h after oral administration, whereas the elimination half-life of the drug was 98.63 h and 136.59 h at 16°C and 10°C, respectively. The peak concentration of enrofl oxacin in plasma and tissues was higher at 16°C than that at 10°C, and the peak plasma concentration time in the liver was the shortest at both temperatures among those of other tissues. The plasma C max /MIC ratio varied between 11.08 and 5 540.00 at 16°C; and between 7.92 and 3 960.00 at 10°C. The AUC/MIC ratio was 467.82-280 690.00 at 16°C, and 359.48-215 690.00 at 10°C. These ratios indicate that it is possible to obtain therapeutic effi cacy. Very low levels of ciprofl oxacin were detected. The AUC ratios of ciprofl oxacin and enrofl oxacin in plasma suggest that plasma ciprofl oxacin might play a minor role in enrofl oxacin treatment for turbot.

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Section: Pharmacokinetic Analysismentioning

confidence: 99%

Pharmacokinetics and tissue behavior of enrofloxacin and its metabolite ciprofloxacin in turbot Scophthalmus maximus at two water temperatures

Liang

Zhao

et al. 2012

Chin. J. Ocean. Limnol.

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“…Furthermore, in crustaceans the volume of haemolymph comprises 22% of the total body weight, compared to 5% in finfish (Barron et al, 1988;Plakas et al, 1990), with the volume of distribution directly related to tissue binding and inversely related to plasma protein binding. Protein binding in finfish is always higher than that found in crustaceans, e.g., 23 and 14-21% in P. japonicus (Uno, 2004) and P. setiferus (Reed et al, 2004), respectively, compared to 51-55% in O. mykiss (Bjorklund and Bylund, 1991;Uno et al, 1997) and 68% in P. altivelis (Uno, 1996). A diminished binding of plasma protein results in an increase in extravascular distribution.…”

Section: Factors That Have An Influence On Pharmacokineticsmentioning

confidence: 93%

Residual pharmaceutically active compounds (PhACs) in aquatic environment - status, toxicity and kinetics: a review

Li¹,

Randák²

2009

Vet. Med. - Czech

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Awareness of residual pharmaceutically active compounds (PhACs) in aquatic ecosystems is growing as research into these pollutants increases and analytical detection techniques improve. For most pharmaceuticals analyzed, the effects on aquatic organisms have usually been investigated by toxic assays in the laboratory. However, little is known about integral analysis of pharmacokinetics in aquatic organisms and specific relations between pharmacokinetic parameters and influence factors. Moreover, the influence of the organisms involved and numerous other external factors complicates development of standard tests for environmental evaluation. Current knowledge about residual pharmaceuticals in the aquatic environment, including status, toxic effects, and pharmacokinetics in aquatic organisms, are reviewed. Based on the above, we identify major gaps in the current knowledge and some directions for future research, such as improvement of techniques to remove residual pharmaceuticals from wastewater, and the establishment of standard pharmaceutical modes of action.

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“…The elimination half-life of OA from black tiger shrimp hemolymph was 17.7 h, which was almost half that found for kuruma shrimp (33.2 h). Uno et al [53] showed that a maximal hemolymph concentration of OA of 4.20 mg/ml was observed at 4 h after oral administration of 50 mg/kg body weight in back tiger shrimp, whereas it was 17.8 mg/ml at 7 h at the same dosing regime in kuruma shrimp [52]. These data indicate that the absorption rate in black tiger shrimp is more rapid than that in kuruma shrimp, whereas the extent of absorption in the former is lower than that in the latter.…”

Section: Antibiotic Residues In Penaeid Shrimpmentioning

confidence: 99%

“…The pharmacokinetic profile of OA has previously been extensively studied in finfish species, but there are few studies on the pharmacokinetics and residues of OA in penaeid shrimp [52,53]. Results from these studies indicated 932 Environ.…”

Section: Antibiotic Residues In Penaeid Shrimpmentioning

confidence: 99%

“…Results from Samuelsen [54] estimated that more than half of the OA applied may be left free in the surrounding environment. The bioavailability of OA was reported to be only 32.9% in kuruma shrimp [52] and as low as 7.9% in black tiger shrimp [53]. Oxytetracycline (OTC) is a commonly used antibiotic to fight bacterial infections in fish farming, and it has the potential to be used in farm-raised shrimp for the treatment of vibriosis and necrotizing hepatopancreatitis infections.…”

Section: Antibiotic Residues In Penaeid Shrimpmentioning

confidence: 99%

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Effects of pesticides and antibiotics on penaeid shrimp with special emphases on behavioral and biomarker responses

Silvestre

Phương

et al. 2010

Enviro Toxic and Chemistry

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Abstract-The purpose of the present study is to provide information on the current state of knowledge regarding the effects of pesticides and antibiotics used in aquaculture on penaeid shrimp, one of the most common aquatic products for human consumption, with a special emphasis on the use of behavioral, physiological, and biochemical response. These include behavior; feeding rate changes; respiration rate, oxygen consumption, and osmoregulation alterations; nucleic acids, protein, and glycogen synthesis; cholinesterase activity inhibition; ATPase activity; and oxidative stress responses. This paper also deals with residues of antibiotics and pesticides in penaeid shrimp. Antibiotics and pesticides used in aquaculture may have adverse effects on treated animals and human consumers health if they are not correctly used. As a complement to the measurement of antibiotic and pesticide residues in tissues, the use of behavioral and biomarker responses can provide more relevant biological information on the potential adverse effects of antibiotics and pesticides on penaeid shrimp health. Environ. Toxicol. Chem. 2010;29:929-938. # 2009 SETAC

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Pharmacokinetics of oxolinic acid and Oxytetracycline in kuruma shrimp, Penaeus japonicus

Cited by 37 publications

References 33 publications

Pharmacokinetics and tissue behavior of enrofloxacin and its metabolite ciprofloxacin in turbot Scophthalmus maximus at two water temperatures

Pharmacokinetics and tissue behavior of enrofloxacin and its metabolite ciprofloxacin in turbot Scophthalmus maximus at two water temperatures

Residual pharmaceutically active compounds (PhACs) in aquatic environment - status, toxicity and kinetics: a review

Effects of pesticides and antibiotics on penaeid shrimp with special emphases on behavioral and biomarker responses

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