Pharmacokinetics of intrapleural cisplatin for the treatment of malignant pleural effusions.

Intrapleural administration of lipoplatin in an animal model

“…The authors reported that the absorption from IPr administration was much slower than that of cisplatin (peak plasma levels 20-30 min vs. 12-24 h), and the peritoneal fluid levels of L-NDDP were several fold higher than those of cisplatin at 6 h [28]. This lower systemic absorption rate of lipoplatin compared to cisplatin after intrapleural administration is probably due to its higher molecular weight suggesting that there may be a cut off to get to the lymphatics through the Wang stomas of the parietal pleura [18,29].…”

“…ity (30]. It is striking that CDDP injected intrapleurally showed no grade 3/4 hematological and lower grade 3/4 non-hematological toxicity in patients with malignant pleural effusion [18] including lung carcinoma [31]. While the rationale behind intrapleural chemotherapy is the direct exposure of tumor cells to higher doses of cytotoxic agents [17], intrapleural administration does not avoid systemic drug exposure.…”

“…Total platinum concentrations were determined in plasma using a GF-AAS (Graphite Furnace Atomic Absorption Spectrometry) assay using an Ati-Unicam model 939QZ, as previously described [14,18]. The quantification limit was 0.02 g/ml and the detection limit was 0.01 g/ml.…”

“…This route of administration might consequently increase the treatment efficacy while decreasing toxicity [17]. Several drugs have been used intrapleurally such as platinum compounds [18,19], etoposide [20], paclitaxel [21] and pemetrexed [22]. We hypothesized that, compared with the intravenous route, intrapleural administration of lipoplatin would both increase pleural tissue exposure and decrease systemic exposure to the drug.…”

Intrapleural Chemo- and Hyperthermotherapies for Malignant Pleural Effusion: A Randomized Prospective Study

“…Combining to other antitumor agents, or high dose (300 mg/m 2 ) of cisplatin in intrapleurally or intravenously [32][33][34][35]. Low dose (60-100 mg/m 2 ) cisplatin was delivered intrapleurally in this study.…”