Pharmacokinetics of doxycycline after a single intravenous, oral or intramuscular dose in Muscovy ducks (<i>Cairina moschata</i>)

Yang, Fan; Sun, Nan; Zhao, Zhensheng; Wang, G. Y.; Wang, M. F.

doi:10.1080/00071668.2014.989488

Cited by 24 publications

(20 citation statements)

References 25 publications

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“…After oral administration, the peak concentrations ( C max s) of AMX and CLV and time to reach them ( t max ) were directly read from the experimental data, and the extent of absolute bioavailability ( F ) was calculated as the ratio of mean oral AUC to the intravenous AUC. The mean absorption time (MAT) after oral administration was calculated as the MRT after oral dosing (MAT oral ) minus that after intravenous administration, and absorption half‐life ( t 1/2ka ) was calculated as 0.693 × MAT oral (Yang et al, ,; Yang, Sun, Zhao, Wang, & Wang, ). After intravenous administration, the parameters calculated are listed below: the volume of distribution ( V z ) was determined using equation V z = (Dose/AUC)/λz, where Dose is the amount of drug administered, and λz is the first‐order rate constant associated with the terminal phase; initial concentration ( C 0 ) was estimated by back‐extrapolating from the first two concentration values; total body clearance (Cl) was calculated as Dose/AUC; and the volume of distribution at steady‐state ( V ss ) was calculated as V ss = MRT × Cl.…”

Section: Methodsmentioning

confidence: 99%

Section: Pharmacokinetic Analysismentioning

confidence: 99%

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Pharmacokinetics of the amoxicillin–clavulanic acid combination after intravenous and oral administration in cats

Yang

Wang

et al. 2019

Vet Pharm & Therapeutics

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The pharmacokinetic properties of amoxicillin (AMX) and clavulanic acid (CLV) were studied in healthy cats following single intravenous and oral dosage of 10 mg/kg of AMX and 2.5 mg/kg of CLV. The drug concentrations in plasma were determined by a high‐performance liquid chromatographic–tandem mass spectrometry (LC‐MS‐MS) method validated for canine plasma and further subjected to noncompartmental analysis. After intravenous injection, no significant difference (p > 0.05) was found in the volume of distribution of these two compounds. In addition, AMX and CLV were both rapidly eliminated from plasma with a clearance of 0.453 and 0.921 L hr−1 kg−1, respectively; however, a quicker elimination was observed for CLV (p < 0.01). After oral administration, both drugs were characterized by rapid absorption with an absorption half‐life of 1.10 and 0.70 hr for AMX and CLV, respectively. Significant differences were observed between their absorption rates (p < 0.05). However, the oral bioavailabilities of AMX and CLV (75.57% and 98.15%, respectively) were not statistically different (p > 0.05). A total intravenous or oral dose at 12.5 mg/kg of AMX and CLV (4:1) is predicted to be effective for treating those bacterial species isolated from cats with a minimum inhibitory concentration (MIC) of ≤0.25 μg/ml for 12 hr, based on a time above the MIC (T > MIC) of 40%.

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Section: Methodsmentioning

confidence: 99%

Section: Pharmacokinetic Analysismentioning

confidence: 99%

Pharmacokinetics of the amoxicillin–clavulanic acid combination after intravenous and oral administration in cats

Yang

Wang

et al. 2019

Vet Pharm & Therapeutics

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“…It was estimated that the BA values in turkeys exposed DC via oral dosing ranged from 40.0 to 83.7% (30). In Muscovy ducks, after oral administration at a dose of 20 mg/kg, the BA values of DC were observed to range from 39.13 to 70.71% (7). A greater BA value was determined at 545.00% in goats receiving a long-acting parenteral formulation of DC hyclate at a dose of 10 mg/kg (10).…”

Section: Discussionmentioning

confidence: 99%

The Pharmacokinetics of Doxycycline in Channel Catfish (Ictalurus punctatus) Following Intravenous and Oral Administrations

Cheng

et al. 2020

Front. Vet. Sci.

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The objective of this study was to investigate the bioavailability (BA) and pharmacokinetics (PK) of doxycycline (DC) in channel catfish (Ictalurus punctatus) following a single intravenous injection at 5 mg/kg and a single oral administration at 50 mg/kg at 24 • C. The calculation of PK parameters was based on the software 3P97. The plasma samples were determined using ultra-performance liquid chromatography. Following oral administration, the multiple-peak phenomenon presented in concentration vs. time curve of DC at 2 h (107.01 mg/L), 8 h (55.07 mg/L), and 72 h (15.10 mg/L), respectively. The compartmental model cannot simulate the oral concentration vs. time profile beside a non-compartmental model. The calculated parameters of the elimination rate constant (λ z), the elimination half-life (t 1/2λz), and the area under the concentration vs. time curve (AUC 0-144) were 0.037 1/h, 18.91 h, and 2255.45 µg.h/mL, respectively. After intravenous administration, the concentration vs. time profile of DC was best described by a two-compartmental open model without absorption. The parameters of the distribution rate constant (α), the distribution half-life (t 1/2α), the elimination rate constant (β), the elimination half-life (t 1/2β), the apparent distribution volume at steady state (V ss), the total clearance (Cl) and the area under the concentration vs. time curve (AUC 0-∞) were 2.79 1/h, 0.25 h, 0.042 1/h, 16.51 h, 300.00 mL/kg, 14.00 mL/h/kg, and 364.99 µg.h/mL, respectively. For the calculation of BA values at the same condition, the data obtained from intravenous injection were also iterated based on a non-compartmental model, and the corresponding parameters of λ z , t 1/2λz , V z , Cl, and AUC 0-144 were 0.019 1/h, 36.26 h, 480.00 mL/kg, 9.10 mL/h/kg, and 514.45 µg.h/mL, respectively. However, there was a considerable difference in the same parameter when calculated by compartmental and non-compartmental approaches. Finally, the medium BA value of DC was evaluated to be 43.84%. This study provides future studies with a framework for determining the BA of DC in the development of a new formulation and provides information on the appropriate use of DC in aquaculture.

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“…The pharmacokinetics parameters were analyzed using a noncompartmental method according to our previous studies (Li et al, ; Yang, Sun, Zhao, Wang, & Wang, ) through the software of WinNonlin (version 5.2.1; Pharsight Corporation). After both routes of administration, the area under the concentration–time curve (AUC) and the first moment curve (AUMC) were both calculated using the linear trapezoidal rule with extrapolation to time infinity (Gibaldi & Perrier, ).…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of ceftiofur sodium in cats following a single intravenous and subcutaneous injection

Zhang

Yang

et al. 2019

Vet Pharm & Therapeutics

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Ceftiofur, a third‐generation cephalosporin antibiotic, is being extensively used by pet doctors in China. In the current study, the detection method was developed for ceftiofur and its metabolites, desfuroylceftiofur (DCE) and desfuroylceftiofur conjugates (DCEC), in feline plasma. Then, the pharmacokinetics studies were performed following one single intravenous and subcutaneous injection of ceftiofur sodium in cats both at 5 mg/kg body weight (BW) (calculated as pure ceftiofur). Ceftiofur, DCE, and DCEC were extracted from plasma samples, then derivatized and further quantified by high‐performance liquid chromatography. The concentrations versus time data were subjected to noncompartmental analysis to obtain the pharmacokinetics parameters. The terminal half‐life (t1/2λz) was calculated as 11.29 ± 1.09 and 10.69 ± 1.31 hr following intravenous and subcutaneous injections, respectively. After intravenous treatment, the total body clearance (Cl) and volume of distribution at steady‐state (VSS) were determined as 14.14 ± 1.09 ml hr‐1 kg‐1 and 241.71 ± 22.40 ml/kg, respectively. After subcutaneous injection, the peak concentration (Cmax; 14.99 ± 2.29 μg/ml) was observed at 4.17 ± 0.41 hr, and the absorption half‐life (t1/2ka) and absolute bioavailability (F) were calculated as 2.83 ± 0.46 hr and 82.95%±9.59%, respectively. The pharmacokinetic profiles of ceftiofur sodium and its related metabolites demonstrated their relatively slow, however, good absorption after subcutaneous administration, poor distribution, and slow elimination in cats. Based on the time of drug concentration above the minimum inhibitory concentration (MIC) (T>MIC) calculated in the current study, an intravenous or subcutaneous dose at 5 mg/kg BW of ceftiofur sodium once daily is predicted to be effective for treating feline bacteria with a MIC value of ≤4.0 μg/ml.

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Pharmacokinetics of doxycycline after a single intravenous, oral or intramuscular dose in Muscovy ducks (Cairina moschata)

Cited by 24 publications

References 25 publications

Pharmacokinetics of the amoxicillin–clavulanic acid combination after intravenous and oral administration in cats

Pharmacokinetics of the amoxicillin–clavulanic acid combination after intravenous and oral administration in cats

The Pharmacokinetics of Doxycycline in Channel Catfish (Ictalurus punctatus) Following Intravenous and Oral Administrations

Pharmacokinetics of ceftiofur sodium in cats following a single intravenous and subcutaneous injection

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