Pharmacokinetics of Clindamycin in Loggerhead Sea Turtles (Caretta caretta) after a Single Intravenous, Intramuscular, or Oral Dose

Harms, Craig A.; Cranston, Elizabeth A.; Papich, Mark G.; Rodriguez, Mauricio X.; Higgins, Benjamin M.; Flanagan, Joseph P.

doi:10.5818/1529-9651-21.4.113

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…However, anatomic and metabolic differences in reptiles and mammals could make extrapolations ineffective or dangerous, resulting in potentially lethal adverse effects. Recent studies have evaluated reptile analgesia (Norton 2005), and the analgesic potential of opioid agonists (Sladky et al 2009), buprenorphine (Kummarov et al 2008, and combinations of bupre norphine and hydromorphone (Mans et al 2012) in red-eared slider turtles Trachemys scripta, of morphine and pethidine in Speke's hinged tortoise Ki nixys spekii (Wambugu et al 2010), ketoprofen in green iguanas Iguana iguana (Tuttle et al 2006), butorphanol and meloxicam in ball pythons Python regius (Olesen et al 2008), meloxicam in green iguanas I. iguana (Divers et al 2010), and meloxicam in loggerhead sea turtles Caretta caretta after single-dose intravenous (Clauss et al 2007) and intramuscular (Soloperto et al 2011) administration. However, the results have often been quite contrasting or unconvincing.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of injuries caused by fishing gear in the intracoelomic digestive tract of sea turtles

Bello¹,

Valastro²,

Freggi³

et al. 2013

Dis. Aquat. Org.

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We report the surgical techniques used to remove accidentally ingested hooks and branchlines localized in different parts of the digestive tract of 129 loggerhead sea turtles Caretta caretta, together with the characteristics and localization of lesions, and final outcome related to their severity. Hooks were removed from the cervical esophagus via the ventral surface of the neck, while the supraplastron approach was performed for hooks wedged in the intracoelomic portion of the esophagus. An approach through the left axillary region was preferred for fishhooks in the stomach, while hooks and long branchlines in the intestine or pyloric area were removed by approaching the coelomic cavity through the right or left prefemoral fossa. The ingestion of fishhooks, and/or longlines, often induces severe injuries in the digestive tract that could lead to the death of the turtles, with the extent of damage engendered by lines often more severe than that caused by hooks, leading to strangulation, intussusception, and tears that require resection of long tracts of intestine. Spontaneous expulsion of hooks, even where possible, involves long waiting times, with the possible impairment of the turtle's clinical condition, and should be avoided when the line is evident or suspected. The development of diversified surgical techniques enabled us to approach the coelomic cavity with minimally invasive and easy-to-perform methods, and survival rates proved very satisfactory.

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Section: Discussionmentioning

confidence: 99%

Surgical treatment of injuries caused by fishing gear in the intracoelomic digestive tract of sea turtles

Bello¹,

Valastro²,

Freggi³

et al. 2013

Dis. Aquat. Org.

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“…Clindamycin was analyzed in wallaby plasma using a previously validated assay that we used for another study (Harms et al., ). We conducted a partial validation using blank (control) wallaby plasma to ensure that the assay accuracy and precision were within the acceptance criteria for the assay.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of intravenous clindamycin phosphate in captive Bennett's wallabies (Macropus rufogriseus)

Watson

Papich

Chinnadurai

2017

Vet Pharm & Therapeutics

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This study was designed to investigate the pharmacokinetics of clindamycin, a lincosamide antibiotic, in Bennett's wallabies. The pharmacokinetic properties of a single intravenous (IV) dose of clindamycin were determined in six wallabies. A single 20-min IV infusion of 20 mg/kg of clindamycin was administered, followed by blood collection prior to, and up to 12 hr after clindamycin administration. Plasma clindamycin concentrations were determined by high-pressure liquid chromatography (HPLC) with ultraviolet (UV) detection. Pharmacokinetic variables were calculated using a two-compartment model with first order elimination which best fit the data. The mean volume of distribution at steady-state, distribution half-life, and elimination half-life were 898.25 ml/kg, 0.16 hr, 1.79 hr, respectively. No adverse effects were noted after IV administration.

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“…Intravenous administration of medications may decrease the variables that influence pharmacokinetics and onset of action of medications and fluids given through alternate routes in critically ill patients in which reliable and quick onset is needed. 5,6 The Seldinger technique is a guide-wire-assisted cannulation method that was initially developed to aid in percutaneous jugular access for angiography. 4 The modified Seldinger technique is an over-the-needle minimally invasive technique in which the practitioner accesses the target vessel with a small bore needle or catheter, and then dilates to the size required for the catheter.…”

Section: Introductionmentioning

confidence: 99%

Jugular Central Venous Catheter Placement Through a Modified Seldinger Technique for Long-Term Venous Access in Chelonians

Pardo¹,

Divers²

2016

Journal of Zoo and Wildlife Medicine

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Long-term or repeated venous access in chelonians is difficult to obtain and manage, but can be critically important for administration of medications and blood sampling in hospitalized patients. Jugular catheterization provides the most rapid and secure route for vascular access, but catheters can be difficult to place, and maintaining catheter patency may be challenging. Long multilumen polyurethane catheters provide flexibility and sampling access, and minimize difficulties, such as catheter displacement, that have been encountered with traditional over-the-needle catheters. We describe placement of 4 Fr. 13-cm polyurethane catheters in three chelonians with the use of a modified Seldinger technique. Venous access was obtained with the use of an over-the-needle catheter, which allowed placement of a 0.018-in.-diameter wire, over which the polyurethane catheter was placed. Indwelling time has ranged between 1 and 4 mo currently. All tortoises were sedated for this procedure. Polyurethane central catheters provide safe, long-term venous access that allows clinicians to perform serial blood sampling as well as intravenous administration of medications, anesthetic agents, and fluids. A jugular catheter can also allow central venous pressure measurement. Utilization of central line catheters was associated with improvements in diagnostic efficiency and therapeutic case management, with minimal risks and complications.

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Pharmacokinetics of Clindamycin in Loggerhead Sea Turtles (Caretta caretta) after a Single Intravenous, Intramuscular, or Oral Dose

Cited by 8 publications

References 29 publications

Surgical treatment of injuries caused by fishing gear in the intracoelomic digestive tract of sea turtles

Surgical treatment of injuries caused by fishing gear in the intracoelomic digestive tract of sea turtles

Pharmacokinetics of intravenous clindamycin phosphate in captive Bennett's wallabies (Macropus rufogriseus)

Jugular Central Venous Catheter Placement Through a Modified Seldinger Technique for Long-Term Venous Access in Chelonians

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