Pharmacokinetics of intravenous clindamycin phosphate in captive Bennett's wallabies (<i>Macropus rufogriseus</i>)

Watson, Megan K.; Papich, Mark G.; Chinnadurai, Sathya K.

doi:10.1111/jvp.12421

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…The distribution time defines the time it takes for drug concentrations in plasma to peak and remain equal throughout the whole body. Data indicate that concentrations within PRF are highest when the sample is drawn directly after the distribution time has passed (and no later), which has been determined to be only a few minutes in duration [ 25 ]. While perioperative prophylaxis lasts only a few hours, an antimicrobial effect with PRF can probably be achieved for 48 h [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of clindamycin-loaded platelet-rich fibrin (PRF)

Straub,

Stapf,

Utz

et al. 2024

Clin Oral Invest

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Objectives Recent research has demonstrated that platelet-rich fibrin (PRF) is an appropriate carrier for ampicillin/sulbactam. The aim of the study was to investigate whether PRF is also a suitable bio-carrier for clindamycin (CLI). Methods PRF membranes were produced from 36 patients receiving intravenous therapy with CLI (e.g. due to the diagnosis of an osteonecrosis of the jaw or infections). Concentrations of CLI in PRF membranes were measured with liquid chromatography-tandem mass spectrometry, and the antimicrobial effects were investigated in vitro in agar diffusion tests with fresh PRF and PRF stored for 24 h. Storage was performed in an incubator at 36 °C to simulate the in-vivo situation. Results The mean concentration of CLI in plasma was 1.0 ± 0.3 μg/100 mg plasma; in resulting PRF membranes 0.7 ± 0.4 μg/100 mg PRF. Agar diffusion tests were performed with Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus mitis, Porphyromonas gingivalis, and Fusobacterium nucleatum. Mean inhibition zones, in mm, for fresh PRF were 17.3, 12.2, 18.8, 17.1, 25.8 and 18.1, 12.7, 19.2, 17.3, and 26.3 for stored PRF, respectively. Conclusion The results demonstrate that PRF is a suitable bio-carrier for CLI when administered systemically to patients. The concentration in PRF generated from patients after infusion of 600 mg CLI dose suffices to target clinically relevant bacteria. Clinical relevance Using PRF as a carrier for local antibiotic application can prevent infections in oral and maxillofacial surgery. Within the study limitations, the findings could expand the scope of PRF application by adding CLI as a new antibiotic to the spectrum of PRF therapy.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of clindamycin-loaded platelet-rich fibrin (PRF)

Straub,

Stapf,

Utz

et al. 2024

Clin Oral Invest

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“…Treatment of kangaroos with MPPD is also carried out with antibiotics. Literature reports highlight the successful use of clindamycin (Watson et al, 2017;Birot et al, 2022). Currently, intravenous oxytetracycline at 10 mg/kg every day, plus oral metronidazole at 60-70 mg/kg is used daily for MPPD.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, intravenous oxytetracycline at 10 mg/kg every day, plus oral metronidazole at 60-70 mg/kg is used daily for MPPD. Antibiotic therapy can continue until at least 2-3 weeks after clinical signs have resolved (Watson et al, 2017). Additionally, there is a mention of adjunctive therapy involving parenteral vitamin A.…”

Section: Discussionmentioning

confidence: 99%

Hematological and Biochemical Parameters of Macropod Progressive Periodontal Disease in Wild Western Gray Kangaroos

Zhelavskyi,

Kernychnyi,

Betlinska

2023

WVJ

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Macropod progressive periodontal disease (MPPD), known as Lumpy Jaw, poses a persistent and potentially fatal threat in Western gray kangaroos when they are kept in captivity. Such a condition leads to the development of osteomyelitis and sepsis in Western gray kangaroos (Macropus fuliginosus). This case study presented the inaugural examination of hematological and biochemical aspects of MPPD with a progression toward sepsis in a captive environment. The primary objective of this research was to pinpoint hematological and biochemical indicators associated with severe MPPD in a Western gray kangaroo held in captivity. The study employed various methods, including clinical, radiographical, hematological, and biochemical analyses, as well as microbiological study methods. The case was a 2.5-year-old male wild Western gray kangaroo with fever (39.7 °C), dehydration, dyspnea, tachycardia, and involuntary jaw clenching due to stress and agitation. The kangaroo had a history of lethargy, anorexia, swelling of the soft tissues of the lower jaw on the left side, and tenderness during palpation. A radiograph of the head revealed mandible proliferative lesions. The hematological and biochemical examinations indicated an increase in the total count of leucocytes, level of neutrophils, number of erythrocytes, hematocrit level, and lymphopenia. Increased activity of alkaline phosphatase, amylase, and creatinine elevated azotemia. There was a decrease in the content of albumin, glucose, and total bilirubin. The bacteria, consisting of Fusobacteriaceae spp., Porphyromonadaceae spp., and Bacteroidaceae spp., were found and identified in all samples. However, this comprehensive diagnosis of MPPD based on clinical signs, radiography, and especially hematological and biochemical parameters of the septic process can be helpful in diagnosis and treatment.

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Diagnostic Imaging of Exotic Pet Mammals and Zoo Animals

Olds

2023

Veterinary Oral Diagnostic Imaging

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Pharmacokinetics of intravenous clindamycin phosphate in captive Bennett's wallabies (Macropus rufogriseus)

Cited by 4 publications

References 23 publications

Antimicrobial effects of clindamycin-loaded platelet-rich fibrin (PRF)

Antimicrobial effects of clindamycin-loaded platelet-rich fibrin (PRF)

Hematological and Biochemical Parameters of Macropod Progressive Periodontal Disease in Wild Western Gray Kangaroos

Diagnostic Imaging of Exotic Pet Mammals and Zoo Animals

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