Pharmacokinetics of ceftiofur sodium in exotic and domestic avian species

Tell, Lisa A.; Harrenstien, Lisa A.; Wetzlich, S. E.; Needham, Martha L.; Nappier, John L.; Hoffman, G.; Caputo, J. F.; Craigmill, Arthur L.

doi:10.1046/j.1365-2885.1998.00124.x

Cited by 36 publications

(33 citation statements)

References 25 publications

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“…This can be concluded from the comparisons of kinetic study results with m.i.c. data, on the one hand, and from experimental therapy studies of infections with bacterial strains of different sensitivities on the other (Brown, 1996;Ziv et al, 1997;Tell et al, 1998;Knoll et al, 1999). However, the latter type of studies has never been performed with O. rhinotracheale.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic sensitivity and resistance inOrnithobacterium rhinotrachealestrains from Belgian broiler chickens

2001

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Establishing the antibiotic sensitivity of the avian respiratory pathogen Ornithobacterium rhinotracheale is difficult because of the organism's complex growth requirements and the unusually frequent occurrence of resistance. The minimal inhibitory concentrations of 10 antibiotics were determined for 45 strains of O. rhinotracheale from Belgian broiler chickens collected from 45 farms between 1995 and 1998. They were compared with the type strain, which was isolated from a turkey, and a strain isolated from a rook. All the broiler strains were resistant to lincomycin and to the b -lactams ampicillin and ceftiofur. Less than 10% of the strains were sensitive to the macrolides tylosin and spiramycin, tilmicosin and flumequine. A few strains were sensitive to enrofloxacin and doxycycline. All strains were sensitive to tiamulin.

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Section: Discussionmentioning

confidence: 99%

Antibiotic sensitivity and resistance inOrnithobacterium rhinotrachealestrains from Belgian broiler chickens

2001

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“…Ceftiofur has been world-widely used for cattle to treat bovine respiratory disease associated with Pasteurella hemolytica, Pasteurella multocida, and Haemophilus somnus, for swine to treat pleuropneumonia caused by Actinobacillus pleuropneumonia, and for chickens to treat fowl typhus and diarrhea associated with Salmonella Garinarium and Escherichia coli [10,18].…”

mentioning

confidence: 99%

“…Tell et al [18] investigated pharmacokinetics of ceftiofur sodium in domestic chicks, cockatiels, and Amazon parrots after subcutaneous (chicks) and intramuscular (cockatiels and Amazon parrot) dosing. At 8 hr after a single subcutaneous injection at the dose of 0.16 mg/chick, the concentration of ceftiofur in plasma of chicks was 0.58 µg/g.…”

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confidence: 99%

Ceftiofur Distribution in Plasma and Tissues Following Subcutaneously Administration in Ducks

Chung¹,

Jung

Kim

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A study was performed to determine the residues in blood and edible tissues of healthy ducks (25 days old, mean body weight 1.0 ± 0.13 kg) after subcutaneous administration of ceftiofur sodium at a dose rate of 2 mg/kg body weight (Group I) and 4 mg/kg body weight (Group II). Blood, muscle, liver, kidney, and fat samples were collected from all of ducks on the 1st, 2nd, 3rd, 4th, and 5th day after treatment of drug, and ceftiofur was analyzed with a high-performance liquid chromatography (HPLC) assay with results reported as ceftiofur-free acid equivalent (CFAE). To study the spiked recovery, blank plasma and tissues were spiked with two different concentrations of ceftiofur sodium (0.1, 0.5 µg/g). Average recovery values for all samples ranged from 70.3 to 87.3%. In the group I, desfuroylceftiofur acetamide (DCA) was not detected in all of plasma, muscle, liver, and fat tissues on the 1st day after treatment. But, kidney samples on the 1st day were detected DCA (0.059 ± 0.01 µg CFAE/g tissue). On the 2nd day of post-treatment, the concentrations of DCA in all tissues were lower than the detection limit, 0.05 µg CFAE /g tissue. In the group II on the 1st day after treatment, the concentration of DCA was 0.124 ± 0.06 µg CFAE/g tissue, 0.103 ± 0.03 µg CFAE/g tissue, and 0.071 ± 0.010 µg CFAE/g tissue in plasma, kidney, and muscle samples, respectively. On the 2nd day after treatment of ceftiofur, the concentrations of DCA in all tissues were lower than 0.05 µg CFAE/g tissue. According to our results, the concentrations of DCA on the 1st day after treatment with 2 mg/ kg body weight were below 0.05 µg CFAE/g tissue equivalent in all tissues except for kidney. On the 2nd day after administration at the dose of 4 mg/kg body weight, no DCA was also detected in all of the tissues although DCA was detected in all samples on the 1st day.

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“…These inconsistencies may be due to the differences in eating habits and/or physiological status. Following a single intravenous injection of ceftiofur sodium, the Cl was estimated as 14.14 ml hr ‐1 kg ‐1 , which was lower than the results reported in Nile tilapia (1,640 ml hr ‐1 kg ‐1 ; Khalil et al, ), cockatiels (678 ml hr ‐1 kg ‐1 ; Tell et al, ), Amazon parrots (228 ml hr ‐1 kg ‐1 ; Tell et al, ), foals (74.4–85.3 ml hr ‐1 kg ‐1 ; Meyer et al, ), and lactating goats (40 ml hr ‐1 kg ‐1 ; Fernandez–Varon et al, ).…”

Section: Discussionmentioning

confidence: 61%

Pharmacokinetics of ceftiofur sodium in cats following a single intravenous and subcutaneous injection

Zhang

Yang

et al. 2019

Vet Pharm & Therapeutics

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Ceftiofur, a third‐generation cephalosporin antibiotic, is being extensively used by pet doctors in China. In the current study, the detection method was developed for ceftiofur and its metabolites, desfuroylceftiofur (DCE) and desfuroylceftiofur conjugates (DCEC), in feline plasma. Then, the pharmacokinetics studies were performed following one single intravenous and subcutaneous injection of ceftiofur sodium in cats both at 5 mg/kg body weight (BW) (calculated as pure ceftiofur). Ceftiofur, DCE, and DCEC were extracted from plasma samples, then derivatized and further quantified by high‐performance liquid chromatography. The concentrations versus time data were subjected to noncompartmental analysis to obtain the pharmacokinetics parameters. The terminal half‐life (t1/2λz) was calculated as 11.29 ± 1.09 and 10.69 ± 1.31 hr following intravenous and subcutaneous injections, respectively. After intravenous treatment, the total body clearance (Cl) and volume of distribution at steady‐state (VSS) were determined as 14.14 ± 1.09 ml hr‐1 kg‐1 and 241.71 ± 22.40 ml/kg, respectively. After subcutaneous injection, the peak concentration (Cmax; 14.99 ± 2.29 μg/ml) was observed at 4.17 ± 0.41 hr, and the absorption half‐life (t1/2ka) and absolute bioavailability (F) were calculated as 2.83 ± 0.46 hr and 82.95%±9.59%, respectively. The pharmacokinetic profiles of ceftiofur sodium and its related metabolites demonstrated their relatively slow, however, good absorption after subcutaneous administration, poor distribution, and slow elimination in cats. Based on the time of drug concentration above the minimum inhibitory concentration (MIC) (T>MIC) calculated in the current study, an intravenous or subcutaneous dose at 5 mg/kg BW of ceftiofur sodium once daily is predicted to be effective for treating feline bacteria with a MIC value of ≤4.0 μg/ml.

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Pharmacokinetics of ceftiofur sodium in exotic and domestic avian species

Cited by 36 publications

References 25 publications

Antibiotic sensitivity and resistance inOrnithobacterium rhinotrachealestrains from Belgian broiler chickens

Antibiotic sensitivity and resistance inOrnithobacterium rhinotrachealestrains from Belgian broiler chickens

Ceftiofur Distribution in Plasma and Tissues Following Subcutaneously Administration in Ducks

Pharmacokinetics of ceftiofur sodium in cats following a single intravenous and subcutaneous injection

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