PLoS ONE volume 9, issue 6, Pe98292 2014 DOI: 10.1371/journal.pone.0098292 View full text
Juan Wang, Xiaofeng Qu, Yanfei Qi, Jinhua Li, Xiuling Song, Li Li, Dehui Yin, Kun Xu, Juan Li

Abstract: Polyoxometalates are non-nucleoside analogs that have been proven to exhibit broad-spectrum antiviral activity. In particular, Cs2K4Na[SiW9Nb3O40].H2O 1 shows low toxicity and high activity against HBV. The preclinical pharmacokinetics of Compound 1 in rats were characterized by establishing and applying inductively coupled plasma-mass spectrometry method to determine the concentration of W in plasma, urine, feces, bile and organ samples. The quantitative ICP-MS method demonstrated good sensitivity and applica…

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