Pharmacokinetics of 2,3,7,8-TCDD in man

Poiger, H.; Schlatter, Ch.

doi:10.1016/0045-6535(86)90429-7

Cited by 199 publications

(91 citation statements)

References 5 publications

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“…We assumed that a simple first -order elimination process, with a half -life of 7.5 years, governed the elimination of TCDD at levels within the range of typical background serum lipid levels over the entire time period of interest ( less than 50 ppt ). This value was chosen as a reasonable central estimate based on the literature (Poiger and Schlatter, 1986;Flesch -Janys et al, 1996;Michalek and Tripathi, 1999;Michalek et al, 2002 ). Change in body burden over time was modeled in an Excel 1 spreadsheet using an incremental model:…”

Section: Modelingmentioning

confidence: 99%

Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Aylward

Hays

2002

J Expo Sci Environ Epidemiol

105

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Data on lipid levels of 2, 3,7, in the general population in the United States, Canada, Germany, and France over the past 30 years were compiled from the literature. Mean lipid levels of TCDD exhibited a steady decrease by nearly a factor of 10 over this time period, with lipid -adjusted TCDD levels in 2000 about 2 parts per trillion ( ppt ). Pharmacokinetic modeling using a one -compartment model indicated that absorbed intake levels of TCDD must have decreased by more than 95% from levels in 1972 to result in the observed decrease in human lipid levels, with the bulk of this decrease occurring before 1980. Based on this modeling and the pharmacokinetic properties of TCDD in humans, we conclude that mean levels of TCDD in the general population are likely to decrease further over the next 15 years, to between 0.5 and 1 ppt, even if intake levels do not decrease further. Fewer data over a shorter time period are available for other dioxin and furan congeners in human lipid, but these data indicate substantial decreases as well, with general population TEQ lipid levels currently at least fourfold lower than in 1970 and still decreasing. Food sampling data are limited, but support these trends.

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Section: Modelingmentioning

confidence: 99%

Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Aylward

Hays

2002

J Expo Sci Environ Epidemiol

105

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“…2,3,7 ,8-TCDD is excreted slowly from the body, with a half-time of three to four weeks in rodent s and even longer in humans (29). A hal f-time of 4.95 years was reported for humans after the ingestion of a single dose of 3H-la beled TCDD (30). No systematic toxicokinetic data are available on the elimination of other PCDD and PCDF from humans.…”

Section: Toxicity Of Pcdd and Pcdfmentioning

confidence: 99%

Chlorinated dioxins and dibenzofurans in the environment--a hazard to public health?

Vainio¹,

Hesso²,

Jäppinen³

1989

Scand J Work Environ Health

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“…From kinetic studies it is established that following a single dose of 1 ng TCDD/kg bw a concentration of 3 pg/g adipose tissue (3 ppt) results, in humans (Poiger and Schlatter, 1986). It is reasonable to assume that 10 ng/kg bw will lead to 30 pg/g lipid (Table 5).…”

Section: Components Of the Human Immune System To Be Consideredmentioning

confidence: 99%

Polychlorinated dibenzo-p-dioxins and the human immune system: 4. Studies on two Spanish families with increased body burdens of highly chlorinated PCDDs

Smith

Hansson

Rodríguez‐Pichardo

et al. 2008

Environment International

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The consequences of exposure of people to highly chlorinated polychlorodibenzop-dioxins (PCDDs) are much less known than those of TCDD. We report on levels of PCDDs (and PCDFs) in 13 members of two families poisoned by contaminated cooking oil. Originally, all persons displayed chloracne as an early symptom.Persisting hexa-and higher chlorinated PCDDs could be analysed many years after exposure. Highest values found in blood lipids were: OCDD 660,000 pg/g; HpCDD 58,000 pg/g; HxCDDs: 3,500 pg/g. None of the participants exhibited increased TCDD levels at the time of study. During a period of 6 years, HpCDD and OCDD disappeared from the blood lipids much faster in persons exposed as children or young adults, than from lipids of their parents. Surface receptors on blood lymphocytes of the members of the two families and the proliferative capacity of these blood cells in the presence of typical stimulants were analysed. Even in family members with the highest body burdens of hexa-to octachlorinated PCDDs we could not detect pronounced changes from a reference population with respect to the immunological markers. Minor deviations of levels of some receptors in a few, but not all, highly exposed persons suggested a similar trend to those reported in previous studies of persons with body burdens of ≥ 3,000 pg TCDD/g blood lipids. An increase in the number of total blood lymphocytes in some subjects exposed as children may have similarity with highly TCDD-exposed children in Seveso.2

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Pharmacokinetics of 2,3,7,8-TCDD in man

Cited by 199 publications

References 5 publications

Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Chlorinated dioxins and dibenzofurans in the environment--a hazard to public health?

Polychlorinated dibenzo-p-dioxins and the human immune system: 4. Studies on two Spanish families with increased body burdens of highly chlorinated PCDDs

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