Pharmacokinetics in Drug Therapy II: Applications of Clinical Pharmacokinetics in The Assessment of Theophylline Therapy

Floyd, Ronald A.; Cohen, Jordan L.

doi:10.1093/ajhp/34.4.402

Cited by 1 publication

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“…Thus, the optimization by monitoring plasma or serum level of theophylline therapy is essential, which will inevitably require the pharmacokinetic principles (Ellis, Koysooko & Levy, 1976;Hendeles et al, 1977;Koup et al, 1976, Leung, Kalisker & Bell, 1977Mitenko & Ogilvie, 1973b;Walson, Strunk & Taussig, 1977). In fact, the recent literatures have implied that one can design a dosage regimen for an individual patient which produces an average plasma or serum theophylline concentration and range of concentrations, if certain kinetic parameters (half-life and clearance) are known (Floyd & Cohen, 1977;Koup et al, 1976;Loughnan, Sitar, Ogilvie & Neris, 1976;Powell et al, 1978). For example, assuming the drug to be completely absorbed, the average dose should be the product of the desired average concentration in plasma and the total plasma clearance unless the drug is eliminated by non-linear (dose-dependent) kinetics (Ellis et al, 1976;Loughnan et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

The effect of assay methods on plasma levels and pharmacokinetics of theophylline: HPLC and EIA.

Ishizaki¹,

Watanabe²,

Morishita³

1979

Brit J Clinical Pharma

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1 The effects of two assay methods, HPLC and EIA, on theophylline plasma levels (n = 254) and pharmacokinetics (n = 6) were examined on blood samples obtained from asthmatic patients and normal adult male volunteers. 2 The standard curves obtained and the plasma level values during plasma level monitoring of theophylline measured with two methods are well correlated each other within concentration range of 2.5 to 20.0 microgram/ml (P less than 0.001). EIA, however in general, appears to give a lower value than HPLC. 3 The values of plasma theophylline half‐life and clearance analyzed using a two‐compartment open system model were found different between the two assay methods and dissimilar to those previously reported by using ultraviolet method. 4 The sampling end‐point and/or assay sensitivity particularly to measure a lower level of theophylline (less than 2.5 microgram/ml) can influence the pharmacokinetics for a potent bronchodilator with a narrow therapeutic margin, theophylline.

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