Pharmacokinetics, distribution and excretion of inulin-type fructan CPA after oral or intravenous administration to mice

Abstract

We develop a simple and efficient method to detect the concentration of the inulin-type fructan CPA from the roots of Codonopsis pilosula (Franch.) Nannf., then apply it to evaluate the pharmacokinetic behavior and distribution character in tissues and excretion in mice.

WITHDRAWN: Study on the pharmacokinetics of Polygonatum cyrtonema polysaccharide DPC1 through fluorescence labeling

“…After oral administration, the levels of DPC1-RhB in the small intestine were higher at 30 min, peaked at 1 h, then rapidly decreased, nally dropping to low levels after 3 h. In contrast, the DPC1-RhB concentration gradually increased and peaked at 4 h in the large intestine. This is consistent with previous ndings [31]. The high solubility and rapid gastrointestinal absorption of DPC1-RhB may further elucidate its comparatively favorable bioavailability [39].…”

“…After a single intraperitoneal administration, DPC1-RhB was swiftly cleared from the plasma, experiencing the most rapid decline in blood concentration values within 2 h, followed by a gradual decrease over 3-6 h, ultimately stabilizing. A similar biphasic elimination phenomenon has been observed in the literature [30,31,37].…”

“…2E, both C max and AUC (0→∞) exhibited a positive correlation with the dose for each dose group, showcasing linear relationships of y = 0.8268x-8.5741 (R 2 = 0.9935) and y = 1.4153x + 24.585 (R 2 = 0.9531), respectively. This suggests that DPC1 demonstrates linear pharmacokinetic characteristics in mice, and similar dose-dependent outcomes were observed in the pharmacokinetic studies of other polysaccharides [25,31,38].…”

“…The C max values were 34.697, 70.236, and 117.374 mg L − 1 , respectively. Subsequently, the plasma concentration of DPC1-RhB decreased rapidly in 1-4 h and stabilized with a slow decrease over time in 6-24 h. Among them, a double peak appeared at 6 h in the medium-and high-dose groups, and similar results were observed in these studies [31,32]. This phenomenon may be associated with the administered dose [33], gastric emptying [34], enterohepatic circulation [35], and P-gp protein expression [36].…”

A review of the botany, ethnopharmacology, phytochemistry, analysis method and quality control, processing methods, pharmacological effects, pharmacokinetics and toxicity of codonopsis radix

“…The concentration of inulin-type fructan CPA in CR was detected by fluorescent labeling method, and the in vivo process of CPA was analyzed. It was found that FCPA could be absorbed through blood circulation after oral administration, with low bioavailability, and its tissue distribution was wide, with long T 1/2 and MRT ( Guo et al, 2022 ). Scholars used UHPLC-Q/TOF-MS and UHPLC-MS/MS methods to analyze the metabolic pathways of three polyacetylene compounds from CR: lobetyol, lobetyolin, and lobetyolinin in vivo and in vitro ( Xie et al, 2023 ) .…”