Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of danofloxacin in Lohi sheep

Abstract

4 was shown by 5 antibiotics and degree 3 was shown by 9 antibiotics after Network Pharmacology analysis. DFT calculations for the antibiotics with a cut-off of degree 3 revealed antibiotic ertapenem with lowest band gap energy, suggesting the highest reactivity. Ertapenem also showed greater LibDock score than the standard antimalarial drugs artemisinin and chloroquine. The binding of ertapenem with its best binding target Plasmodium dUTPase was validated as stable binding by molecular dynamic simulation. Conclusion:The present in silico study shows that the broad spectrum antibiotic ertapenem is a potential inhibitor of multiple Plasmodium proteins viz. dUTPase, Oxidised Thioredoxin Reductase and Falcipain-2 with good binding affinity. Molecular dynamics of ertapenem and its best binding protein dUTPase shows the stable binding of the complex. Hence, present findings may help future studies in the development of potential multi-targeting next generation anti-malarial lead compounds.

Exploration of Clinical Breakpoint of Danofloxacin for Glaesserella parasuis in Plasma and in PELF

“…Quinolones are effective for treating G. parasuis infection because of their strong bactericidal activity and good absorption into the blood and great distribution in the lung [5]. When intravenous injection of danofloxacin 2.5 mg/kg, the distribution half-life was 0.21 ± 0.004 h and Vd area was 6.41 ± 0.0.94 L/kg in sheep plasma [6]. Danofloxacin, one of the most important fluoroquinolones, has a broad spectrum of antimicrobial activity and has been widely used in different animals, such as in sheep [7], bees [8], rabbits [9], turkeys [10], cattle and swine [11].…”