2020
DOI: 10.3390/molecules25133069
|View full text |Cite
|
Sign up to set email alerts
|

Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry

Abstract: 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) is a bioactive compound that shows excellent anti-inflammatory properties. However, its pharmacokinetics and metabolism have yet to be evaluated. In this study, a sensitive LC-HRMS method was developed and validated to quantify tHGA in rat plasma. The method showed good linearity (0.5–80 ng/mL). The accuracy and precision were within 10%. Pharmacokinetic investigations were performed on three groups of six rats. The first two groups were given oral administ… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 26 publications
0
3
0
Order By: Relevance
“…A hybrid QqQ linear ion‐trap is a less employed mass analyzer (Tanner et al, 2019). To date, LC‐HRMS is starting to be used for the pharmacokinetic studies of small molecules, for example, LC coupled with quadrupole in tandem with Orbitrap (Alkhateeb et al, 2020; Park et al, 2021; Qian et al, 2022; Wang, Wang, et al, 2019). The number of publications on this topic has been rising every year.…”
Section: Ms‐based Methods In the Analysis Of Small‐molecule Chemical ...mentioning
confidence: 99%
“…A hybrid QqQ linear ion‐trap is a less employed mass analyzer (Tanner et al, 2019). To date, LC‐HRMS is starting to be used for the pharmacokinetic studies of small molecules, for example, LC coupled with quadrupole in tandem with Orbitrap (Alkhateeb et al, 2020; Park et al, 2021; Qian et al, 2022; Wang, Wang, et al, 2019). The number of publications on this topic has been rising every year.…”
Section: Ms‐based Methods In the Analysis Of Small‐molecule Chemical ...mentioning
confidence: 99%
“…A variety of nanoparticle carriers, including liposomes, lipidic carriers, micelles, polymeric materials, dendrimers, nanosuspensions, and nanoemulsions, have been used as controlled drug delivery vehicle systems . To date, polymeric (e.g., chitosan, starch, phytoglycogen, and alginate), lipid, liposome, and γ-cyclodextrin materials have been employed for the encapsulation of phloroglucinol in nanocomplex forms as therapeutic drugs. Bai et al loaded phlorotannin into whey protein isolate–chitosan oligosaccharide nanocomplexes to increase antioxidant and anti-inflammatory effects. Recently, phloroglucinol was encapsulated into chitosan in the form of nanoparticles (CSNPs) and demonstrated promising antibiofilm activity on C. albicans and bacterial mono- and dual-species biofilms (Figure B).…”
Section: Alternative Strategies Employed For the Application Of Pg An...mentioning
confidence: 99%
“…Taken together, these computational findings strongly validate that tHGA is a safe drug candidate that has the potential to be further developed as a modern medication for treating various diseases. It is important to note that findings from a pharmacokinetic study on tHGA has demonstrated that the oral bioavailability of tHGA in mice was not high ( Alkhateeb et al, 2020 ). However, liposomal formulation has successfully improved the relative oral bioavailability of tHGA from 9.1 to 21.0% which was a 2.3-fold increment.…”
Section: The Way Forwardmentioning
confidence: 99%