Pharmacokinetics and in vivo delivery of curcumin by copolymeric mPEG-PCL micelles

Manjili, Hamidreza Kheiri; Ghasemi, Parisa; Malvandi, Hojjat; Mousavi, Mir Sajjad; Attari, Elahe; Danafar, Hossein

doi:10.1016/j.ejpb.2016.10.003

Cited by 84 publications

(62 citation statements)

References 31 publications

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“…In our experiment, CUR was still detectable in plasma after 6 h, in accordance with literature data (Reza Kheiri Manjili et al, 2016), although at very low concentrations.…”

Section: Resultssupporting

confidence: 93%

“…A simultaneous fivefold increase of the maximum experimental plasma concentration ( C max ) and reduction of the corresponding peak time ( T max ) from 120 to 90 min were registered ( Figure 5 ). In particular, the increase of C max obtained after the oral administration of microparticles was not far from the improvement recently registered upon multiple oral administration of CUR-loaded polymeric nano-sized micelles (Reza Kheiri Manjili et al, 2016). Most noteworthy, CUR plasma levels after the administration of microparticles remained at values just below the T max (400-450 μg/ml) for the entire duration of the experiment (6 h) ( Figure 5 ), indicating a sustained release of the drug from the polymeric carrier and a prolonged gastro-intestinal absorption.…”

Section: Resultsmentioning

confidence: 61%

“…After oral administration, neat CUR is characterized by a relatively fast absorption, after which the drug plasma concentration decreased rapidly, due to distribution and metabolization, resulting in a short t 1/2 (approximately 1.32 h) (Reza Kheiri Manjili et al, 2016). In our experiment, CUR was still detectable in plasma after 6 h, in accordance with literature data (Reza Kheiri Manjili et al, 2016), although at very low concentrations.…”

Section: Resultsmentioning

confidence: 99%

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Improvement of Oral Bioavailability of Curcumin upon Microencapsulation with Methacrylic Copolymers

et al. 2016

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Curcumin (diferuloymethane; CUR) is a yellow pigment used in traditional medicine throughout history for its anti-inflammatory activity. In the last years, the scientific research has demonstrated that CUR effects are related to the modulation of crucial molecular targets, related to several pathologies including cancer, arthritis, diabetes, Crohn’s disease. In this paper, two formulations of microencapsulated CUR obtained by coevaporation with polymethacrylate polymers (Eudragit® Retard) were investigated in vitro, ex vivo, and in vivo, and results were compared by laser confocal microscopy analysis. The permeation of microencapsulated CUR through CaCo-2 monolayers was evaluated in vitro. The mucoadhesion and bioadhesion of the CUR-loaded microparticles were evaluated in vitro, using E12 and CaCo-2 human intestinal cells, and ex vivo, by means of excised rat intestinal mucosa. After oral administration to rats, microencapsulated CUR showed a sevenfold increase of bioavailability in respect to the neat drug, with a concomitant reduction of the Tmax and a five-fold plasma concentration peak increase.

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“…In our experiment, CUR was still detectable in plasma after 6 h, in accordance with literature data (Reza Kheiri Manjili et al, 2016), although at very low concentrations.…”

Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

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Improvement of Oral Bioavailability of Curcumin upon Microencapsulation with Methacrylic Copolymers

et al. 2016

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“…Shukla and Gupta (2010) demonstrated that apigenin could support the improvement of cardiovascular disorders, excite immune system and deliver some defense alongside skin, thyroid, endometrial, gastric, liver, and adrenal cortical cancers (21). Patel et al (2007) suggested that in the future, apigenin owns high possibility for progress as a capable cancer chemopreventive factor (22).…”

Section: Introductionmentioning

confidence: 99%

Genetically Transformed Root-Based Culture Technology in Medicinal Plant Cosmos bipinnatus

Jaberi¹,

Sharafi²,

Sharafi³

et al. 2018

Jundishapur J Nat Pharm Prod

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Background: Cosmos bipinnatus is an important medicinal plant with antioxidative, antigenotoxic, anti-inflammatory, and antiproliferative effects on several cancer cell lines. It has great potential for development as a promising cancer chemo-preventive agent. Hairy root-based culture technology is a new sustainable production platform for producing specific pharmaceutical secondary metabolites. Objectives: The current study developed and introduced a reliable transformation system for C. bipinnatus by optimization of aspects important in transformation frequency using Agrobacterium rhizogenes. Methods: Five bacterial strains, including ATCC 15834, ATCC 31798, A7, MAFF-02-10266, and MSU440, 2 explant types (leaf and stem), and 2 co-cultivation media (full MS and ½ MS) were examined. Genomic DNA was extracted using a modified CTAB protocol from putative transgenic root lines and the control root. Transgenic hairy root lines were approved by means of Polymerase Chain Reaction (PCR) using specific rolB gene primers. Results:The highest ratio of genetically transformed root induction was found from leaf explants using A. rhisogenes strains ATCC15834 and MSU440 (72% to 73%). When ½ MS medium was used as a co-cultivation medium, a significant increase in transformation frequency (84%) was observed. Conclusions: The MSU440 Agrobacterium strain and ½ MS co-cultivation medium could significantly improve genetic transformation efficiency for establishment of hairy root-based cultures for C. bipinnatus.

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“…Micelles formed by mono methoxy poly (ethylene glycol)-block-poly (ε-caprolactone) (mPEG-PCL) diblock copolymers are able to encapsulate curcumin with a high drug loading capacity of 20 wt.% and with a remarkably enhanced drug half-life t 1/2 and low cytotoxicity compared to curcumin in solution [8]. Rhamnolipids have been explored as nanocarriers for dermal treatment mimicking bacterial bio-surfactants [9].…”

mentioning

confidence: 99%

Nanocarriers: Architecture, transport, and topical application of drugs for therapeutic use

Naolou

Rühl

Lendlein

2017

European Journal of Pharmaceutics and Biopharmaceutics

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Skin as the largest organ of the human body is taken in view by pharmacists for topical or transdermal drug delivery. The biological barrier of healthy skin, more specifically the stratum corneum layer (SC), limits the penetration of bioactive substances [1]. Various attempts have been performed to overcome this barrier including applications of ultrasound, electroporation, microneedles, magnetophoresis, or iontophoresis [2]. The successful treatment of inflammatory skin diseases requires an efficient transport of exact, clinically relevant dosage to the targeted site in a way that possible side effects of drugs can be avoided [3]. In this respect, nano-sized polymeric carrier systems for dermal drug delivery represent an elegant strategy to be explored in dermatology in order to increase the penetration depth of applied drugs into skin compared to conventional formulations. In fact, many morphological and physiochemical properties of nanocarriers, such as shape, charge, surface properties, size, and particle softness have an impact on their drug-loading efficiency, skin penetration depth, and interaction with various skin tissues [4]. These interrelated factors turn the task of finding the ideal nanocarrier system for topical treatment into a challenge, especially as the fundamental knowledge related to the interaction of different types of nanoparticles with different skin layers and subsequently to the drug release is still lacking. The development of nanocarriers for the delivery of bioactive molecules in a controlled way for specific treatment of inflammatory skin diseases requires a multidisciplinary approach [5].

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Pharmacokinetics and in vivo delivery of curcumin by copolymeric mPEG-PCL micelles

Cited by 84 publications

References 31 publications

Improvement of Oral Bioavailability of Curcumin upon Microencapsulation with Methacrylic Copolymers

Improvement of Oral Bioavailability of Curcumin upon Microencapsulation with Methacrylic Copolymers

Genetically Transformed Root-Based Culture Technology in Medicinal Plant Cosmos bipinnatus

Nanocarriers: Architecture, transport, and topical application of drugs for therapeutic use

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