Pharmacokinetics and haemodynamic effects of prolonged methohexitone infusion.

Normand, Y. Le; Villepoix, C. De; Pinaud, M∘; Bernard, Jean-Marc; Fraboul, J P; Athouel, A.; Ribeyrol, M.; Beneroso, N.; Larousse, C

doi:10.1111/j.1365-2125.1988.tb05299.x

Cited by 10 publications

(8 citation statements)

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“…There is some evidence that a single large dose of barbiturate can cause substantial auto-induction of metabolizing enzymes [20]. There was no apparent enzyme induction in the patients treated by Le Normand and colleagues [3]; however, the methohexitone infusion was 6 h shorter than in our study, and in elderly patients the capacity for enzyme induction may be low, as has been shown with antipyrine [21]. In our young patients, enzyme induction might have occurred.…”

Section: Discussionsupporting

confidence: 46%

“…The mean clearance of methohexitone in our patients (16.3 ml min" 1 kg" 1 ) was greater than in young volunteers (12.1 ml min" 1 kg" 1 ) [6], surgical patients (10.9 ml min" 1 kg" 1 ) [4]; 8.2-9.3 ml min" 1 kg" 1 [5]) or in elderly postoperative patients (9.3-9.8 ml min" 1 kg" 1 ) [3]. This increase in clearance may be a result of several factors, for example fever, changes in liver blood flow or induction of hepatic mixed function oxidases.…”

Section: Discussionmentioning

confidence: 99%

“…anaesthesia is controversial. Undesirable haemodynamic effects [1,2], excessive post-infusion sedation [3] and convulsions [2] have been reported following such infusions.…”

mentioning

confidence: 99%

“…Thus the clearance of methohexitone was found to be substantially greater in patients with hepatitis than in normal subjects [8]. During and after long-term (14 h) infusions in elderly patients recovering from major surgery, the clearance of methohexitone was comparable to that in volunteers and surgical patients, while the volume of distribution was increased markedly and the terminal half-life prolonged [3].…”

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confidence: 99%

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Pharmacokinetics and Clinical Experience of 20-H Infusions of Methohexitone in Intensive Care Patients With Postoperative Pyrexia

Redke

Björkman

Rosberg

1991

British Journal of Anaesthesia

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We have studied the pharmacokinetics of 20-h infusions of methohexitone in young patients with postoperative fever undergoing artificial ventilation of the lungs. The infusion rate was adjusted so that patients were unresponsive to vocal stimulation but reacted to tracheal suction. The mean steady state concentration of methohexitone required was 2.6 mg litre-1 (unbound 0.53 mg litre-1). The mean (SD) total clearance of methohexitone was 16.3 (4.2) ml min-1 kg-1, which is greater than that for volunteers or normal surgical patients. The unbound clearance correlated positively with body temperature during the infusion (r = 0.796, P = 0.017). The terminal half-life of methohexitone was 6.3 (3.8) h and that of the 4'-hydroxy metabolite 5.8 (2.1) h. There were no marked haemodynamic effects of the infusion, and no excessive sedation after the infusion. However, the clearance of methohexitone was high and variable, possibly as a direct effect of postoperative fever. Consequently, the need for individual titration of the rate of infusion is emphasized.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

“…anaesthesia is controversial. Undesirable haemodynamic effects [1,2], excessive post-infusion sedation [3] and convulsions [2] have been reported following such infusions.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Pharmacokinetics and Clinical Experience of 20-H Infusions of Methohexitone in Intensive Care Patients With Postoperative Pyrexia

Redke

Björkman

Rosberg

1991

British Journal of Anaesthesia

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“…minimal cardiovascular depression, and cerebral protection during ischaemic episodes. Methohexitone has a more appropriate kinetic profile for IV anaesthesia (elimination half-life of 420-460 minutes, and clearance of 700-800 ml/min) (Breimer et al, 1976le Normand et al, 1988. The main metabolite, 4-OH methohexitone, is pharmacologically inactive.…”

Section: Advantages Of Thiopentone Infusions Includementioning

confidence: 99%

Recent Advances in Intravenous Anaesthesia

Sear

1991

Journal of Veterinary Anaesthesia

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Psychopharmacological Agents

Martin

Godel

Hunkeler

et al. 2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Martin, James R.; Godel, T.; Hunkeler, W.; Jenck, F.; Moreau, J‐L.; Sleight, A. J.; and Widmer, U. (F. Hoffmann‐La Roche Ltd.). A number of important advances have occurred in the understanding and the treatment of disorders of the central nervous system including mood disorders, schizophrenia, anxiety disorders, insomnia, substance use disorders, and dementias. The plethora of novel drugs act by means of diverse neurobiological mechanisms and represent a great diversity of chemical structures. Along with improvements in the therapeutic index of anxiolytics, sedative–hypnotics, antidepressants, and antipsychotics, some progress has also been made in the search for drugs effective in the treatment of substance use disorders, as well as Alzheimer's disease and other dementias. Nonetheless, such improvements in symptomatic therapy have not been accompanied by the discovery of effective etiological and pathophysiological interventions. It is from here that the successful psychopharmacological agents of the future must come.

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Pharmacokinetics and haemodynamic effects of prolonged methohexitone infusion.

Cited by 10 publications

References 11 publications

Pharmacokinetics and Clinical Experience of 20-H Infusions of Methohexitone in Intensive Care Patients With Postoperative Pyrexia

Pharmacokinetics and Clinical Experience of 20-H Infusions of Methohexitone in Intensive Care Patients With Postoperative Pyrexia

Recent Advances in Intravenous Anaesthesia

Psychopharmacological Agents

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