Pharmacokinetics and efficacy of intraocular flurbiprofen

Abstract

Flurbiprofen is effective in suppressing inflammation in this experimental uveitis model. In our experimental setting, intravitreal flurbiprofen seem to have a therapeutic result comparable to dexamethasone. However, the half-life of the drug remains short, necessitating further research to prolong its presence in the vitreous cavity.

Prevention and treatment of cystoid macular edema after cataract surgery

“…95 It remains debatable whether a single intravitreal NSAID injection is suitable for prevention of postoperative inflammation and CME, considering the half-life of two to three hours after intravitreal injection of diclofenac, flurbiprofen and ketorolac. [96][97][98] Given the short half-life of intravitreal NSAIDs, authors recommend frequent injections at short intervals (hours-days) to achieve lasting therapeutic levels. 96 The safety of repeated intravitreal NSAID treatment remains to be investigated.…”

“…[96][97][98] Given the short half-life of intravitreal NSAIDs, authors recommend frequent injections at short intervals (hours-days) to achieve lasting therapeutic levels. 96 The safety of repeated intravitreal NSAID treatment remains to be investigated. Moreover, repeated intravitreal injections increase the risk of endophthalmitis, a dreaded complication that is reported in 4-5 per 10,000 injections.…”