Pharmacokinetics and distribution of a biodegradable drug-carrier

Grislain, L.; Couvreur, Patrick; Lenaerts, Vincent; Roland, M; Deprezdecampeneere, D.; Speiser, P

doi:10.1016/0378-5173(83)90166-7

Cited by 285 publications

(100 citation statements)

References 10 publications

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“…The MRT of Dox delivered through DP nanoparticles was lower than for the Dox solution, while that for Dox delivered through EP nanoparticles was higher than for Dox solution. The AUC [0][1][2][3][4][5][6][7][8] , AUC 0-∞ and AUMC 0-8 of Dox delivered through nanoparticles were significantly higher than for Dox solution. The bioavailability of Dox was greatly enhanced by DP (1.9 fold) and EP nanoparticles (2.12 fold).…”

Section: Resultsmentioning

confidence: 99%

“…2 Polybutyl cyanoacrylate (PBC) nanoparticles have gained increasing interest in the drug delivery for pharmaceutical and medical applications. These nanoparticles alter the body distribution of incorporated drugs 3 , protect the drugs against enzymatic degradation 4 , and reduce the toxic effects of drug molecules. 5 Majority of the earlier studies reported the dispersion polymerization technique for the synthesis of PBC nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…routes and the respective pharmacokinetics and tissue distribution were determined. Both types of nanoparticles significantly enhanced the elimination half-life (T 1/2 ), mean residence time (MRT) AUC [0][1][2][3][4][5][6][7][8] , AUC 0-∞ and AUMC 0-8 of Dox in blood after i.v. injection.…”

mentioning

confidence: 99%

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Pharmacokinetics and Biodistribution Studies of Doxorubicin Loaded Poly(butyl Cyanoacrylate) Nanoparticles Synthesized by Two Different Techniques

Reddy¹,

Murthy²

2004

BIOMED PAP

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The aim of the study is to determine and compare the pharmacokinetics and tissue distribution of Doxorubicin (Dox) delivered as solution or through nanoparticles after intravenous (i.v.) and intraperitoneal (i.p.) injection. Doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles were synthesized by dispersion polymerization (DP) and emulsion polymerization (EP) techniques. The drug loaded DP and EP nanoparticles were administered by i.v. or i.p. routes and the respective pharmacokinetics and tissue distribution were determined. Both types of nanoparticles significantly enhanced the elimination half-life (T 1/2 ), mean residence time (MRT) AUC [0][1][2][3][4][5][6][7][8] , AUC 0-∞ and AUMC 0-8 of Dox in blood after i.v. injection. Dox delivered through DP nanoparticles rapidly disappeared from blood and distributed to the organs of reticuloendothelial system (RES). But, the clearance of Dox delivered through EP nanoparticles from blood was slower than this of the DP nanoparticles and Dox solution. After i.p. injection, the Dox loaded into DP nanoparticles quickly appeared in blood and undergone rapid distribution to the organs of RES, while the Dox loaded into EP nanoparticles absorbed slowly into blood and remained in the circulation for longer time. The absorption into blood of Dox delivered through DP and EP nanoparticles after i.p. injection was relatively rapid and higher than Dox solution. The T 1/2 , MRT, AUC [0][1][2][3][4][5][6][7][8] , AUC 0-∞ and AUMC 0-8 of Dox in blood were significantly higher and the clearance (Cl) was lower than for the Dox solution after i.p. injection. The tissue concentrations of Dox delivered through nanoparticles after i.p. injection were significantly lower than after i.v. injection. The bioavailability (F) of Dox was greatly enhanced by DP (∼1.9 fold) and EP nanoparticles (∼2.12 fold) compared to Dox solution after i.p. injection. EP nanoparticles significantly enhanced the bioavailability, MRT, T 1/2 , AUC 0-8 , AUC 0-∞ and AUMC 0-8 of Dox than DP nanoparticles. This signifies the advantage of EP nanoparticles in increasing the elimination half-life of Dox both after i.v. and i.p. injection and enhanced bioavailability after i.p. injection, which is expected to improve the therapeutic efficacy of Dox and reduce the Dox-associated systemic toxicity. Importantly, both DP and EP nanoparticles greatly reduced the distribution of Dox to heart both after i.v. and i.p. injection, suggesting their potential in reducing Dox-associated cardiotoxicity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics and Biodistribution Studies of Doxorubicin Loaded Poly(butyl Cyanoacrylate) Nanoparticles Synthesized by Two Different Techniques

Reddy¹,

Murthy²

2004

BIOMED PAP

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“…Firstly, synthesis of such NPs was reported by Couvreur et al [12]. Afterwards, several studies were reported around molecular weight distribution, toxicity, pharmacokinetics, bio distribution, stability and conjugation of different drugs [11,[15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Polybutylcyanoacrylate Nanoparticles and Drugs of the Platinum Family: Last Status

et al. 2013

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Cisplatinum and carboplatinum drugs from platinum-containing family are anti-cancer drugs. Using these drugs causes side effects. Targeted and selective prescription decreases side effects of the drugs. This can be achieved using nanotechnology. In this study, cisplatinum and carboplatinum drugs were loaded on polybutylcyanoacrylate nanoparticles using emulsion polymerization method. To determine amount of loaded drug onto nanoparticle, spectrophotometry method was used. Evaluation of cytotoxicity of such nanoparticles was performed on MCF-7 cell line using MTT assay. Loading percentage of cisplatinum and carboplatinum drugs on nanoparticles were estimated 4 and 6 %, respectively. Cytotoxicity survival rate for cisplatinum and nanoparticle containing cisplatinum at the lowest concentration (p \ 0.01) (20 lM) were estimated 64 ± 1 and 67 ± 0.5 %, respectively. These values at the highest concentration (p \ 0.01) (160 lM) were measured 28 ± 0.7 and 31 ± 0.4 %. Additionally for carboplatinum and nanoparticles containing carboplatinum at the concentration (p \ 0.01) (20 lM) amounts were estimated to be 80 ± 0.6 and 84 ± 0.6 %, while at the concentration (p \ 0.01) (160 lM) were identified to be 44 ± 0.5 and 51 ± 0.2 %, respectively. Probably, due to low level of loading, cytotoxicity of both drugs at nano particle status was decreased in comparison with their standard form.

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“…Poly(butylcyanoacrylate) has proven to be the most promising material in vivo because of its rapid degradation [79]. Biodegradability can work in favor of peptidic nanoparticles.…”

Section: Peptidic Nanoparticlesmentioning

confidence: 99%

The role of peptides in blood‐brain barrier nanotechnology

Teixidó

Giralt

2007

Journal of Peptide Science

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Abstract:The blood-brain barrier (BBB) regulates the passage of molecules between the bloodstream and the brain. Overcoming the difficulty of delivery drugs to specific areas of the brain is a major challenge. The BBB exerts a neuroprotective function as it hinders the delivery of diagnostic and therapeutic agents to the brain. Here, we provide an overview of the way in which peptides and nanotechnology are being exploited in tandem to address this problem. Peptides can be used as specialised coatings able to transport nanoparticles with specific properties, such as targeting. The nanoparticle can also carry a peptide drug. Furthermore, peptides can be used in less conventional approaches such as all-peptide nanoparticles. In summary, the combined use of peptides and nanotechnology offers tremendous hope in the treatment of brain disorders.

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Pharmacokinetics and distribution of a biodegradable drug-carrier

Cited by 285 publications

References 10 publications

Pharmacokinetics and Biodistribution Studies of Doxorubicin Loaded Poly(butyl Cyanoacrylate) Nanoparticles Synthesized by Two Different Techniques

Pharmacokinetics and Biodistribution Studies of Doxorubicin Loaded Poly(butyl Cyanoacrylate) Nanoparticles Synthesized by Two Different Techniques

Polybutylcyanoacrylate Nanoparticles and Drugs of the Platinum Family: Last Status

The role of peptides in blood‐brain barrier nanotechnology

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