Pharmacokinetic study of mangiferin in human plasma after oral administration

Hou, Shaoying; Wang, Fang; Li, Yingmei; Li, Ying; Wang, Maoqing; Sun, Di; Sun, Changhao

doi:10.1016/j.foodchem.2011.10.079

Cited by 71 publications

(50 citation statements)

References 22 publications

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“…After oral administration of SZR decoction, the insomnic group exhibited a remarkable decrease ( p < 0.05) in the value of AUC 0‐t , AUC 0‐∞ and C max , and increase ( p < 0.05) of T 1/2 associated with spinosin and mangiferin. The results might be attributed to different mechanisms of absorption and metabolism among the three compounds . Spinosin and mangiferin are both flavonoids, which means they may have similar absorbing and metabolic routes.…”

Section: Resultsmentioning

confidence: 99%

“…Spinosin and mangiferin are both flavonoids, which means they may have similar absorbing and metabolic routes. It was found that spinosin and mangiferin were absorbed and degraded in intestinal tracts related to microflora or enzymes . Sleeplessness may have caused a great decrease in enzyme activity, resulting in poor absorption of spinosin and mangiferin in plasma.…”

Section: Resultsmentioning

confidence: 99%

“…c) is ubiquitous and abundant in many plants, which was reported to have auxiliary curative effect on insomnia . A number of HPLC or LC/MS methods have been developed to determine each of these analytes in plasma separately . However, there is no method established for simultaneous estimation of these three active ingredients for pharmacokinetic investigations.…”

Section: Introductionmentioning

confidence: 99%

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A UFLC‐MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats

Jia

et al. 2012

J. Mass. Spectrom.

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Suan-Zao-Ren (SZR) decoction, consisting of Ziziphi Spinosae Semen, Poria, Chuanxiong Rhizoma, Anemarrhenae Rhizoma and Glycyrrhizae Radix Et Rhizoma, is a Traditional Chinese Medicine prescription, clinically used for the treatment of insomnia. The objective of this study was to develop a sensitive and reliable UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid, the main active ingredients in SZR decoction, and to compare the pharmacokinetics of these active ingredients in normal and insomnic rats orally administrated with the prescription. Analytes and IS were separated on a Shim-pack XR-ODS column (75 mm × 3.0 mm, 2.2 µm particles) using gradient elution with the mobile phase consisting of methanol and 0.1% formic acid in water at a flow rate of 0.4 mL/min. The detection of the analytes was performed on 4000Q UFLC-MS/MS system with turbo ion spray source in the negative ion and multiple reaction-monitoring mode. The lower limits of quantification were 1, 6 and 1 ng/mL for spinosin, mangiferin and ferulic acid, respectively. Intra- and inter-day precision and accuracy of analytes were well within acceptance criteria (15%). The mean extraction recoveries of analytes and IS from rats plasma were all more than 85.0%. The validated method has been successfully applied to comparing pharmacokinetic profiles of analytes in rat plasma. The results indicated that no significant difference in pharmacokinetic parameters of ferulic acid was observed between two groups, while absorptions of spinosin and mangiferin in insomnic group were significantly lower than those in normal group.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A UFLC‐MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats

Jia

et al. 2012

J. Mass. Spectrom.

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“…Due to the complexity of the other constituents in the formulation, the principle constituent will be decreasing its binding affinity toward the plasma proteins and increasing its free drug concentration which shows the therapeutic effects and gets rapidly eliminated. Also, there will always be a strong correlation between plasma drug concentration and the intensity of its therapeutic and toxic effects (23). For example, the C max and AUC of visnagin were increased after oral administration of Ammi visnaga extract compared with a single constituent (24).…”

Section: Discussionmentioning

confidence: 99%

Comparative Pharmacokinetic Study of Mangiferin After Oral Administration of Pure Mangiferin and US Patented Polyherbal Formulation to Rats

et al. 2014

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Abstract. The US patented polyherbal formulation for the prevention and management of type II diabetes and its vascular complications was used for the present study. The xanthone glycoside mangiferin is one of the major effector constituents in the Salacia species with potential anti-diabetic activity. The pharmacokinetic differences of mangiferin following oral administration of pure mangiferin and polyherbal formulation containing Salacia species were studied with approximately the same dose 30 mg/kg mangiferin and its distribution among the major tissue in Wistar rats. Plasma samples were collected at different time points (15, 30, 60, 120, 180, 240, 360, 480, 600,1,440,2,160, and 2880 min) and subsequently analyzed using a validated simple and rapid LC-MS method. Plasma concentration versus time profiles were explored by non-compartmental analysis. Mangiferin plasma exposure was significantly increased when administered from formulation compared to the standard mangiferin. Mangiferin resided significantly longer in the body (last mean residence time (MRT last )) when given in the form of the formulation (3.65 h). C max values of formulation (44.16 μg/mL) administration were elevated when compared to equivalent dose of the pure mangiferin (15.23 μg/mL). Tissue distribution study of mangiferin from polyherbal formulation was also studied. In conclusion, the exposure of mangiferin is enhanced after formulation and administration and could result in superior efficacy of polyherbal formulation when compared to an equivalent dose of mangiferin. The results indicate that the reason which delays the elimination of mangiferin and enhances its bioavailability might the interactions of the some other constituents present in the polyherbal formulation. Distribution study results indicate that mangiferin was extensively bound to the various tissues like the small intestine, heart, kidney, spleen, and liver except brain tissue.

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“…The limit of detection for Oxy-Di-OA was defined as the amount of drug at which the signal to noise ratio of the testing peak was 3:1. The limit of quantitation was the lowest concentration on the standard curve [34]. …”

Section: Methodsmentioning

confidence: 99%

A New Oleanolic Acid Derivative against CCl4-Induced Hepatic Fibrosis in Rats

Xiang

Han

Zhang

et al. 2017

IJMS

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A novel hepatoprotective oleanolic acid derivative, 3-oxours-oleana-9(11), 12-dien-28-oic acid (Oxy-Di-OA), has been reported. In previous studies, we found that Oxy-Di-OA presented the anti-HBV (Hepatitis B Virus) activity (IC50 = 3.13 µg/mL). Remarkably, it is superior to lamivudine in the inhibition of the rebound of the viral replication rate. Furthermore, Oxy-Di-OA showed good performance of anti-HBV activity in vivo. Some studies showed that liver fibrosis may affiliate with HBV gene mutations. In addition, the anti-hepatic fibrosis activity of Oxy-Di-OA has not been studied. Therefore, we evaluated the protective effect of Oxy-Di-OA against carbon tetrachloride (CCl4)-induced liver injury in rats. Daily intraperitoneally administration of Oxy-Di-OA prevented the development of CCl4-induced liver fibrosis, which was evidenced by histological study and immunohistochemical analysis. The entire experimental protocol lasted nine weeks. Oxy-Di-OA significantly suppressed the increases of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (p < 0.05). Furthermore, Oxy-Di-OA could prevent expression of transforming growth factor β1 (TGF-β1). It is worth noting that the high-dose group Oxy-Di-OA is superior to bifendate in elevating hepatic function. Compared to the model group, Oxy-Di-OA in the high-dose group and low-dose group can significantly reduce the liver and spleen indices (p < 0.05). The acute toxicity test showed that LD50 and a 95% confidence interval (CIs) value of Oxy-Di-OA were 714.83 mg/kg and 639.73–798.73 mg/kg via intraperitoneal injection in mice, respectively. The LD50 value of Oxy-Di-OA exceeded 2000 mg/kg via gavage in mice. In addition, a simple and rapid high performance liquid chromatography-ultraviolet (HPLC-UV) method was developed and validated to study the pharmacokinetic characteristics of the compound. After single-dose oral administration, time to reach peak concentration of Oxy-Di-OA (Cmax = 8.18 ± 0.66 μg/mL) was 10 ± 2.19 h; the elimination half-life and area under the concentration-time curve from t = 0 to the last time of Oxy-Di-OA was 2.19 h and 90.21 μg·h/mL, respectively.

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Pharmacokinetic study of mangiferin in human plasma after oral administration

Cited by 71 publications

References 22 publications

A UFLC‐MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats

A UFLC‐MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats

Comparative Pharmacokinetic Study of Mangiferin After Oral Administration of Pure Mangiferin and US Patented Polyherbal Formulation to Rats

A New Oleanolic Acid Derivative against CCl4-Induced Hepatic Fibrosis in Rats

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