2015
DOI: 10.1002/bmc.3641
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Pharmacokinetic study of dendrobine in rat plasma by ultra‐performance liquid chromatography tandem mass spectrometry

Abstract: Dendrobine, considered as the major active alkaloid compound, has been used for the quality control and discrimination of Dendrobium which is documented in the Chinese Pharmacopoeia. In this work, a sensitive and simple ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for determination of dendrobine in rat plasma is developed. After addition of caulophyline as an internal standard (IS), protein precipitation by acetonitrile-methanol (9:1, v/v) was used to prepare samples. Ch… Show more

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Cited by 34 publications
(23 citation statements)
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References 9 publications
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“…A variety of sample preparation techniques have been applied in a bioanalytical method such as protein precipitation, liquid-liquid extraction, and solid-phase extraction [32]. Among these, the most widely used are protein precipitation and liquid-liquid extraction followed by solid-phase extraction which are used in different category such as antibiotic [33][34][35][36][37][38][39][40], anticancer [36,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62], antiviral [63][64][65][66][67], antifungal [68][69][70][71][72], cardiovascular [73][74][75][76][77]…”
Section: Application Of Uhplc-ms/msmentioning
confidence: 99%
“…A variety of sample preparation techniques have been applied in a bioanalytical method such as protein precipitation, liquid-liquid extraction, and solid-phase extraction [32]. Among these, the most widely used are protein precipitation and liquid-liquid extraction followed by solid-phase extraction which are used in different category such as antibiotic [33][34][35][36][37][38][39][40], anticancer [36,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62], antiviral [63][64][65][66][67], antifungal [68][69][70][71][72], cardiovascular [73][74][75][76][77]…”
Section: Application Of Uhplc-ms/msmentioning
confidence: 99%
“…Despite the quite unusual structure of some of these compounds, limited information is available on their bioactivities. One of the most important alkaloids in Dendrobium genus is dendrobin ( 45 ), which has been used in the Chinese Pharmacopoeia for the quality control of Dendrobium raw material . A possible use of dendrobine was evaluated for the protective effects on cortical neurons injured by oxygen‐glucose deprivation/reperfusion (OGD/RP) in vitro .…”
Section: Introductionmentioning
confidence: 99%
“…Proteins and other potential interference would affect the analysis of the mass spectrometry system [ 34 , 35 ]. Therefore, an effective and simple sample preparation was a key point for establishing the UPLC-MS/MS method of TBMS-I.…”
Section: Resultsmentioning
confidence: 99%