Pharmacokinetic study comparing pure desoxo-narchinol A and nardosinonediol with extracts from Nardostachys jatamansi

Le, Vu Ngoc Han; Zhao, Yaxian; Cho, Chong Woon; Na, MinKyun; Quan, Khong Trong; Kim, Young Ho; Hwang, Sung Yeoun; Kim, Sang Wook; Kang, Jong Seong

doi:10.1016/j.jchromb.2018.10.003

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…Due to the presence of secondary peaks in the plasma concentration-time profiles, terminal phase could not be easily defined and t 1/2 , area under the plasma concentration-time curve (AUC inf ), and apparent clearance (CL/F) were estimated from the limited number of animals. The rapid absorption and prolonged terminal t 1/2 after oral absorption is consistent with the recent literature report, which reported the T max and t 1/2 of desoxo-narchinol A of 7.5 ± 2.7 min and 248.8 ± 135.2 min, respectively, following oral administration in rats [18]. The extended terminal phases of desoxo-narchinol A was also observed following oral administration of extracts from Nardostachys jatamansi [18].…”

Section: Resultssupporting

confidence: 91%

“…The main advantages of the present method include the simplicity and low cost of the single-step protein precipitation over other extraction methods. Although solid-phase extraction has been effectively used to extract desoxo-narchinol A and nardosinonediol from plasma [18], it involves greater complexity, lengthy sample preparation time, and higher cost.…”

Section: Resultsmentioning

confidence: 99%

“…To date, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) of nardosinone, another active ingredient of Nardostachys jatamansi , has been developed and applied to characterize its pharmacokinetics following intravenous injection in rats [17]. For desoxo-narchinol A, there is only one recent pharmacokinetic study after oral administrations of desoxo-narchinol A and extracts of Nardostachys jatamansi in rats by applying an LC-MS/MS method [18]. However, the LC-MS/MS utilized solid-phase extraction, which requires long sample preparation time and cost.…”

Section: Introductionmentioning

confidence: 99%

“…However, the LC-MS/MS utilized solid-phase extraction, which requires long sample preparation time and cost. Moreover, the pharmacokinetics were only determined following oral administration in rats [18]. Its oral bioavailability and comprehensive pharmacokinetic characteristics are still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice

et al. 2019

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Desoxo-narchinol A is one of the major active constituents from Nardostachys jatamansi, which has been reported to possess various pharmacological activities, including anti-inflammatory, antioxidant, and anticonvulsant activity. A simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of desoxo-narchinol A in two different biological matrices, i.e., rat plasma and mouse plasma, using sildenafil as an internal standard (IS). The method involved simple protein precipitation with acetonitrile and the analyte was separated by gradient elution using 100% acetonitrile and 0.1% formic acid in water as a mobile phase. The MS detection was performed with a turbo electrospray in positive ion mode. The lower limit of quantification was 10 ng/mL in both rat and mouse plasma. Intra- and inter-day accuracies were in the ranges of 97.23–104.54% in the rat plasma and 95.90–110.11% in the mouse plasma. The precisions were within 8.65% and 6.46% in the rat and mouse plasma, respectively. The method was applied to examine the pharmacokinetics of desoxo-narchinol A, and the oral bioavailability of desoxo-narchinol A was 18.1% in rats and 28.4% in mice. The present results may be useful for further preclinical and clinical studies of desoxo-narchinol A.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice

et al. 2019

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“…There is an increasing trend in number of research papers produced on N. chinensis. Recently, a number of studies have been conducted on pharmacology and phytochemistry of N. chinensis (Jin, Xiao, Qun, Li, & Liu, 2018;Kapoor, Yadav, Chopra, Mahapatra, & Agrawal, 2017;Ko et al, 2018;Le et al, 2018;Liu et al, 2018;Rehman et al, 2017;Shen et al, 2017;Shen et al, 2018;Song et al, 2018;Zhang et al, 2018).…”

mentioning

confidence: 99%

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Rehman

Ahmad

2019

Phytotherapy Research

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Nardostachys chinensis Batalin (Valerianaceae) has been widely used in different traditional systems of medicine, including Islamic, Ayurvedic, Chinese, and Korean folk medicine. It has been used in traditional medicine as a tranquilizer, hepatotonic, cardiotonic, diuretic, and analgesic. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its traditional uses. This review aims to summarize reported traditional uses, phytochemistry, and pharmacological potential of N. chinensis while identifying potential areas of further research of plant. The review comprises literature pertaining to the pharmacological potential and phytochemistry of N. chinensis using worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, Pub Med, Scopus, Springer, Wiley online library). Moreover, data from ethno botanical text books available in library and electronic search were also included. The Plant List and Kew Herbarium Catalogue databases were used to authenticate the scientific name. Different pharmacological experiments in many in vitro and in vivo models have proved the potential of N. chinensis, namely, antiinflammatory, anticonvulsant, antibacterial, antihypertensive, antifungal, neuroprotective, cardioprotective, aldose reductase inhibition, and antioxidant activities. The plant contains sesquiterpenenes of various varieties including aristolane, guaiane, and nardosinane types. Moreover, it also contains coumarins, phenols, lignans, neolignans, and glycosides. Reported activities suggested that there may be pharmacological potential for developing N. chinensis as a drug for infections, hypertension, cardiac diseases, Alzheimer's disease, insomnia, epilepsy, cancer, gastric, and liver diseases. More toxicological studies should be performed that will aid the progress to clinical trial studies of N. chinensis. Abbreviations: 2K1C, two-kidney one-clip; 5-HT, 5-hydroxytryptamine; ABTS, 2,2′-azino-bis; AChEI, acetylcholinesterase; BChE, butyrylcholinesterase; Bcl-2, B-cell lymphoma 2; CDK, cyclindependent kinase; dbcAMP, dibutyryl cyclic adenosine mono phosphate; Dct, dopachrometautomerase; DPPH, 2,2, diphenyly 1-picryl hydrazyl; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; EV, estradiol valerate; FRAP, ferric reducing antioxidant power; GAP-43, growth associated protein 43; ICAM-1, intracellular cell adhesion molecule 1; IP-10, interferon gamma-induced protein 10; I-TAC, interferon-inducible T-cell alpha chemo attractant; IVSd, interventricular septal diameter at end-diastole; IVSs, interventricular septal diameter at end-systole; LDL, low-density lipoprotein; LPS, lipopolysaccharide; LTA, lipoteichoic acid; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; LVPWd, left ventricular posterior wall at end-diastole; LVPWs, left ventricular posteriorwall at end-systole; LVW/BW, left vent...

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Recent Advances and Trends in Applications of Solid-Phase Extraction Techniques in Food and Environmental Analysis

Faraji¹,

Yamini

Gholami³

2019

Chromatographia

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Pharmacokinetic study comparing pure desoxo-narchinol A and nardosinonediol with extracts from Nardostachys jatamansi

Cited by 6 publications

References 25 publications

Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice

Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Recent Advances and Trends in Applications of Solid-Phase Extraction Techniques in Food and Environmental Analysis

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