Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats

Tagliati, Carlos Alberto; Kimura, Elza; Nothenberg, Michael Simon; Santos, Sı́lvia R.J.C; Oga, Seizi

doi:10.1016/s0306-3623(98)00267-5

Cited by 32 publications

(21 citation statements)

References 15 publications

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“…Our results suggested that the higher initial plasma concentrations of piroxicam in gelatin microcapsule were due to the increase in dissolution rate of piroxicam in the gelatin microcapsule in rats. 27,28) The pharmacokinetic parameters are shown in Table 1. The gelatin microcapsule gave significantly higher AUC and C max of piroxicam than did piroxicam powder ( pϽ0.05).…”

Section: 21) Results and Discussionmentioning

confidence: 99%

Preparation and in Vivo Evaluation of Piroxicam-Loaded Gelatin Microcapsule by Spray Drying Technique

Piao

Yang

et al. 2008

Biological & Pharmaceutical Bulletin

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To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then evaluated compared to piroxicam powder. The piroxicam-loaded gelatin microcapsule spherical in shape with smooth surface showed the geometric mean diameter of about 19 m mm. It had the piroxicam solubility of about 1.87 mg/ml and the amount of ethanol of about 4.37 m mg/mg. Furthermore, it gave significantly higher total plasma concentrations, C max and area under the blood concentration-time curve (AUC ) of piroxicam in rats than did piroxicam powder, indicating that the drug from gelatin microcapsule could be more orally absorbed in rats. In particular, the AUC of piroxicam in gelatin microcapsule was significantly about 2 fold increased compared to piroxicam powder. This enhanced oral relative bioavailability of piroxicam in gelatin microcapsule was contributed by the marked increase in the absorption rate of piroxicam due to the improved solubility of piroxicam. Thus, the piroxicam-loaded gelatin microcapsule developed using spray-drying technique with gelatin, sodium lauryl sulfate and ethanol would be useful to deliver piroxicam in a pattern that allows fast absorption in the initial phase, leading to better absorption.

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Section: 21) Results and Discussionmentioning

confidence: 99%

Preparation and in Vivo Evaluation of Piroxicam-Loaded Gelatin Microcapsule by Spray Drying Technique

Piao

Yang

et al. 2008

Biological & Pharmaceutical Bulletin

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“…Zinc has an important role in gastric function and pathology. Zinc is important for gastric acid secretion reduction and tissue healing (Kadakia et al 1992;Mann et al 1992;Watanabe et al 1995;Troskot et al 1997;Tagliati et al 1999). A few clinical and animal studies have shown the effect of zinc components in treatment and prevention of peptic ulcer (Cho et al 1985;Bandyopadhyay and Bandyopadhyay 1997;Santos et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Transient receptor potential melastatin type 7 channels are involved in zinc-induced apoptosis in gastric cancer

Kim¹

2011

Animal Cells and Systems

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“…The limited solubility of PXM leads to a delayed onset of therapeutic effect. Oral absorption is slow and gradual with maximum absorption occurring 3 -5 hours after administration and a long half-life of elimination [34].…”

Section: Introductionmentioning

confidence: 99%

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Adebisi

Kaialy

Hussain

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2016.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 4. GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations. Technique could be used to determine appropriate formulations that improve handling AbstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging was also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM.XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 µm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5 nC/g for untreated material and -7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1 -0.3 3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

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Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats

Cited by 32 publications

References 15 publications

Preparation and in Vivo Evaluation of Piroxicam-Loaded Gelatin Microcapsule by Spray Drying Technique

Preparation and in Vivo Evaluation of Piroxicam-Loaded Gelatin Microcapsule by Spray Drying Technique

Transient receptor potential melastatin type 7 channels are involved in zinc-induced apoptosis in gastric cancer

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

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