Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

Wang, Jun; Chen, Yue; Chen, Baoan; Ding, Jia-Hua; Xia, Guohua; Gao, Chong; Cheng, Jian; Jin, Nan; Zhou, Ying; Li, Xiaomao; Tang, Meng; Wang, Xue Mei

doi:10.2147/ijn.s13662

Cited by 76 publications

(24 citation statements)

References 16 publications

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“…1,2 Apart from these, SPION are intensively explored in neuro-medicine because they can cross the blood-brain barrier (BBB). 3 Examples of recent developments include the synthesis of enhanced contrast agents for early detection of brain tumors via MRI 4–6 as well as magnetic 7 and convection-enhanced 8 drug-delivery systems targeting brain tumor or tissue. In all these applications, the particles are functionalized with different surface chemistries to target specific sites or organelles, enhance cellular uptake or improve retention without deleterious cell reactions.…”

Section: Introductionmentioning

confidence: 99%

Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity

Rivet

Yuan

Borca-Tasciuc

et al. 2011

Chem. Res. Toxicol.

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Superparamagnetic iron oxide nanoparticles, with diameters in the range of a few tens of nanometers, display the ability to cross the blood-brain barrier and are envisioned as diagnostic and therapeutic tools in neuro-medicine. However, despite the numerous applications being explored, insufficient information is available on their potential toxic effect on neurons. While iron oxide has been shown to pose a decreased risk of toxicity, surface functionalization, often employed for targeted delivery, can significantly alter the biological response. This aspect is addressed in the present study, which investigates the response of primary cortical neurons to iron oxide nanoparticles with coatings frequently used in biomedical applications: aminosilane, dextran, and polydimethylamine. Prior to administering the particles to neuronal cultures, each particle type was thoroughly characterized to assess the (1) size of individual nanoparticles, (2) concentration of the particles in solution and (3) agglomeration size and morphology. Culture results show that polydimethylamine functionalized nanoparticles induce cell death at all concentrations tested by swift and complete removal of the plasma membrane. Aminosilane coated particles affected metabolic activity only at higher concentrations while leaving the membrane intact and dextran-coated nanoparticles partially altered viability at higher concentrations. These findings suggest that nanoparticle characterization and primary cell-based cytotoxicity evaluation should be completed prior to applying nanomaterials to the nervous system.

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Section: Introductionmentioning

confidence: 99%

Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity

Rivet

Yuan

Borca-Tasciuc

et al. 2011

Chem. Res. Toxicol.

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“…For instance, in one study, the maximum accumulation of Fe 3 O 4 nanoparticles was in the lung and kidneys at 6 hrs, liver, brain, stomach and small intestine on day 1 post-administration and the heart and spleen on day 3 post-administration. The highest concentrations of nanoparticles were observed in the liver (one-day post administration) and spleen (three days post administration) (26). A potential strategy to overcome the need for direct injection of magnetic nanoparticles into tumor is to administer them intravenously and home them specifically to tumor cells or subcellular compartments of tumor cells to enhance treatment efficacy.…”

Section: Nanoparticles For Htmentioning

confidence: 99%

Hyperthermia using nanoparticles – Promises and pitfalls

Kaur

Aliru

Chadha

et al. 2016

International Journal of Hyperthermia

183

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An ever-increasing body of literature affirms the physical and biological basis for sensitization of tumors to conventional therapies such as chemotherapy and radiation therapy by mild temperature hyperthermia. This knowledge has fueled the efforts to attain, maintain, measure and monitor temperature via technological advances. A relatively new entrant in the field of hyperthermia is nanotechnology which capitalizes on locally injected or systemically administered nanoparticles that are activated by extrinsic energy sources to generate heat. This review describes the kinds of nanoparticles available for hyperthermia generation, their activation sources, their characteristics, and the unique opportunities and challenges with nanoparticle-mediated hyperthermia.

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“…The BBB serves as a gate in preventing dangerous substances from entering the central nervous system (CNS), however, in doing so other important substances, including drugs for treating CNS pathologies like Parkinson’s disease, Alzheimer, infections and tumors are equally prevented [24,25]. Amidst these difficulties some inorganic nanoparticles of iron oxide (ION) were able to reach the brain in significant concentrations in experimental animals [26]. The same type of nanoparticle (ION) showed over 80% uptake of Amyloid beta (Aβ) in the presence of intact and un-inflamed BBB in rats [27].…”

Section: Reviewmentioning

confidence: 99%

“…Mg–Al–LDH/Zn-Al-LDHCo-precipitation_80mg/kg of ketoprofenMagnifying lensMucosal surface[21]Ketoprofen induced gastritis was reduced with LDH intercalation11. Mg–Al–LDHCo-precipitation_5-2000mg/kgBlood chemistryBalb/c mice[26]No significant changes to clinical and biochemical parameters and no evidence of particle retention in tissues.12. Zn-Al-LDHCo-precipitation/ion exchange_1.2MTTChang liver cells (N)[29]Lower concentration used and no effect on viability from either the carrier or loaded LDH13.…”

Section: Introductionmentioning

confidence: 99%

Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity and drug activity enhancement

Kura

Hussein²,

Fakurazi

et al. 2014

Chemistry Central Journal

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The production of layered double hydroxide(LDH) nanocomposite as an alternative drug delivery system against various ailments is on the increase. Their toxicity potential is usually dose and time dependent with particle sizes, shapes and surface charge playing some role both in the in vitro and in vivo studies. The reticular endothelial system of especially the liver and spleen were shown to sequestrate most of these nanocomposite, especially those with sizes greater than 50 nm. The intracellular drug delivery by these particles is mainly via endocytotic pathways aided by the surface charges in most cases. However, structural modification of these nanocomposite via coating using different types of material may lower the toxicity where present. More importantly, the coating may serve as targeting ligand hence, directing drug distribution and leading to proper drug delivery to specific area of need; it equally decreases the unwanted nanocomposite accumulation in especially the liver and spleen. These nanocomposite have the advantage of wider bio-distribution irrespective of route of administration, excellent targeted delivery potential with ease of synthetic modification including coating.

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Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

Cited by 76 publications

References 16 publications

Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity

Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity

Hyperthermia using nanoparticles – Promises and pitfalls

Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity and drug activity enhancement

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