Hyperthermia using nanoparticles – Promises and pitfalls

Kaur, Punit; Aliru, Maureen; Chadha, Awalpreet S.; Asea, Alexzander; Krishnan, Sunil

doi:10.3109/02656736.2015.1120889

Cited by 174 publications

(92 citation statements)

References 93 publications

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“…The temperature of cells incubated with F-108@TPP-AuNP rose to 39 8Cf rom room temperature, whereas the temperature of untreated cells merely rose to 29 8C ( Figure 4b). [35,36] Cell viability tests were performed to evaluate the combined effects of chemotherapy and hyperthermia ( Figure S20, Supporting Information). HeLa cells were incubatedf or 4h at 37 8Cw ith no additive, with TPP-Au I Cl or F-108@TPP-AuNP ([TPP] = 10 mm); as ample from each of these sets of cells was then subjected to 532 nm laser irradiation for 10 min (Figure 4c).…”

Section: Resultsmentioning

confidence: 99%

Aqueous Synthesis of Triphenylphosphine‐Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy

Benyettou

Nair

Dho

et al. 2020

Chemistry A European J

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Triphenylphosphine (TPP) surface-functionalized and F-108P luronic-stabilized gold nanoparticles (F-108@TPP-AuNPs)h ave been synthesized through ao ne-step approach,l eading to well-defined (9.6 AE 1.6 nm) and watersolublen anoparticles by microwaveh eating an aqueous solution of TPP-Au I Cl in the presence of aP luronic polymer under basic conditions. TPP release was negligible under physiological conditions, bute nhanced significantly at an acidic pH (5.4) mimickingt hat of ac ancerc ell. Laser irradiation (532 nm) raised the temperature of an aqueous solution of F-108@TPP-AuNPs to 51.7 8Cw ithin 5min, confirming efficient light-to-heat conversion capabilities withouts ignificant photodegradation. TEM confirmed intracellular localization of F-108@TPP-AuNPsi nt he cytosol, endosomes and lysosomeso fH eLa cells.F -108@TPP-AuNPs were well tolerated by HeLa cells and zebrafish embryos at ambient temperatures and becamet oxic upon heat activation, suggesting synergistic interactions between heat and cytotoxic action by TPP.

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Section: Resultsmentioning

confidence: 99%

Aqueous Synthesis of Triphenylphosphine‐Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy

Benyettou

Nair

Dho

et al. 2020

Chemistry A European J

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“…In the mag.SLP, the heating efficiency, and thus ability to boost the degradation of lipid matrix, was directly related to the contribution of magnetic phase as it is the source of heat. In general, heating under the applied AMF is a result of transformation of magnetic energy through the Brownian motion and Néel relaxation into thermal energy (Kaur et al, 2016). The linear part of the plot measured at 30 • C represented stable temperature conditions of the mag.SLP dispersion before the field application (Figure 2e).…”

Section: Discussionmentioning

confidence: 99%

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

et al. 2020

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Magnetic and temperature-sensitive solid lipid particles (mag. SLPs) were prepared in the presence of oleic acid-coated iron oxide (IO-OA) nanoparticles with 1-tetradecanol and poly(ethylene oxide)-block-poly(ε-caprolactone) as lipid and stabilizing surfactant-like agents, respectively. The particles, typically ∼850 nm in hydrodynamic size, showed heat dissipation under the applied alternating magnetic field. Cytotoxic activity of the mag.SLPs, non-magnetic SLPs, and iron oxide nanoparticles was compared concerning the mammalian cancer cell lines and their drug-resistant counterparts using trypan blue exclusion test and MTT assay. The mag.SLPs exhibited dose-dependent cytotoxicity against human leukemia cell lines growing in suspension (Jurkat and HL-60/wt), as well as the doxorubicin (Dox)-and vincristine-resistant HL-60 sublines. The mag.SLPs showed higher cytotoxicity toward drug-resistant sublines as compared to Dox. The human glioblastoma cell line U251 growing in a monolayer culture was also sensitive to mag.SLPs cytotoxicity. Staining of U251 cells with the fluorescent dyes Hoechst 33342 and propidium iodide (PI) revealed that mag.SLPs treatment resulted in an increased number of cells with condensed chromatin and/or fragmented nuclei as well as with blebbing of the plasma membranes. While the Hoechst 33342 staining of cell suggested the pro-apoptotic activity of the particles, the PI staining indicated the pro-necrotic changes in the target cells. These conclusions were confirmed by Western blot analysis of apoptosis-related proteins, study of DNA fragmentation (DNA laddering due to the inter-nucleosomal cleavage and DNA comets due to single strand breaks), as well as by FACS analysis of the patterns of cell cycle distribution (pre-G1 phase) and Annexin V/PI staining of the treated Jurkat cells. The induction of apoptosis or necrosis by the particles used to treat Jurkat cells depended on the dose of the particles. Production of the reactive oxygen species (ROS) was proposed as a potential mechanism of mag.SLPs-induced cytotoxicity. Accordingly, hydrogen peroxide and superoxide radical Ś więtek et al.Magnetic Solid-Lipid Particles levels in mag.SLPs-treated Jurkat leukemic cells were increased by ∼20-40 and ∼70%, respectively. In contrast, the non-magnetic SLPs and neat iron oxides did not influence ROS levels significantly. Thus, the developed mag.SLPs can be used for effective killing of human tumor cells, including drug-resistant ones.

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“…(vi) SPIONs (superparamagnetic iron oxide nanoparticles) and core-shell nanoparticles The ability of iron oxide NPs to produce strong contrast images in RMI in T1(longitudinal relaxation-spin-lattice) and T2 (transversal relaxation-spin-spin) has given them a place in the theranostics of cancer [189,190]. This novel imaging system using iron oxide nanoparticles (IONP) has been used in several xenograft model [191,192], for MRI diagnostic in TNBC [188].…”

Section: (I) Quantum Dots (Qd)mentioning

confidence: 99%

Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies

Medina

Oza

Sharma

et al. 2020

IJERPH

192

164

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Triple-negative breast cancer (TNBC) cells are deficient in estrogen, progesterone and ERBB2 receptor expression, presenting a particularly challenging therapeutic target due to their highly invasive nature and relatively low response to therapeutics. There is an absence of specific treatment strategies for this tumor subgroup, and hence TNBC is managed with conventional therapeutics, often leading to systemic relapse. In terms of histology and transcription profile these cancers have similarities to BRCA-1-linked breast cancers, and it is hypothesized that BRCA1 pathway is non-functional in this type of breast cancer. In this review article, we discuss the different receptors expressed by TNBC as well as the diversity of different signaling pathways targeted by TNBC therapeutics, for example, Notch, Hedgehog, Wnt/b-Catenin as well as TGF-beta signaling pathways. Additionally, many epidermal growth factor receptor (EGFR), poly (ADP-ribose) polymerase (PARP) and mammalian target of rapamycin (mTOR) inhibitors effectively inhibit the TNBCs, but they face challenges of either resistance to drugs or relapse. The resistance of TNBC to conventional therapeutic agents has helped in the advancement of advanced TNBC therapeutic approaches including hyperthermia, photodynamic therapy, as well as nanomedicine-based targeted therapeutics of drugs, miRNA, siRNA, and aptamers, which will also be discussed. Artificial intelligence is another tool that is presented to enhance the diagnosis of TNBC.

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Hyperthermia using nanoparticles – Promises and pitfalls

Cited by 174 publications

References 93 publications

Aqueous Synthesis of Triphenylphosphine‐Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy

Aqueous Synthesis of Triphenylphosphine‐Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies

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