Aqueous Synthesis of Triphenylphosphine‐Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy

Benyettou, Farah; Nair, Anjana Ramdas; Dho, Yaereen; Prakasam, Thirumurugan; Pasricha, Renu; Whelan, Jamie; Traboulsi, Hussein; Mazher, Javed; Sadler, Kirsten C.; Trabolsi, Ali

doi:10.1002/chem.202000216

Cited by 8 publications

(3 citation statements)

References 58 publications

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“…In another recent study, triphenylphosphine (TPP) surface‐functionalized and F‐108 Pluronic‐stabilized GNPs, presenting a new compound (F‐108@TPP‐AuNPs) with unique properties like water stability, TPP‐controlled release, photostability, high light‐to‐heat conversion capabilities, were proposed. In the in vivo and in vitro trial on Hela cells, this compound, when exposed to irradiation, showed superior anticancer activity through apoptosis mechanism due to the synergism between chemotherapy and hyperthermia with a clear advantage of the combined vs individual therapies [137].…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Asadi

Bianchi

Landro

et al. 2020

Journal of Biophotonics

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Gold nanoparticles (GNPs)‐based photothermal therapy (PTT) is a promising minimally invasive thermal therapy for the treatment of focal malignancies. Although GNPs‐based PTT has been known for over two decades and GNPs possess unique properties as therapeutic agents, the delivery of a safe and effective therapy is still an open question. This review aims at providing relevant and recent information on the usage of GNPs in combination with the laser to treat cancers, pointing out the practical aspects that bear on the therapy outcome. Emphasis is given to the assessment of the GNPs’ properties and the physical mechanisms underlying the laser‐induced heat generation in GNPs‐loaded tissues. The main techniques available for temperature measurement and the current theoretical simulation approaches predicting the therapeutic outcome are reviewed. Topical challenges in delivering safe thermal dosage are also presented with the aim to discuss the state‐of‐the‐art and the future perspective in the field of GNPs‐mediated PTT.

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Section: Gold Nanoparticlesmentioning

confidence: 99%

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Asadi

Bianchi

Landro

et al. 2020

Journal of Biophotonics

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“…Indeed, Ag additives to composite coatings on Ti materials have received the bulk of research attention; however, nontoxic and cytocompatible AuNPs, have shown uniquely advantageous broad-spectrum antibacterial activity against both pathogenic Gram-positive and Gram-negative bacteria [101,102]. In the recent past, triphenylphosphine (TPP)-stabilised AuNPs (TPP-AuNPs) have been explored as the precursor material for clinical applications, such as immunolabelling and therapeutics [103][104][105][106][107]. Furthermore, AuNPs stabilised by monosulfonated triphenylphosphine (TPPMS; IUPAC nomenclature: (m-sulfonatophenyl) diphenylphosphane) have been reported to exhibit in vitro antibacterial response.…”

Section: Metal Nanoparticle Coatingsmentioning

confidence: 99%

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Braem

Kamarudin

Bhaskar

et al. 2023

International Materials Reviews

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Peri-implant infection is rapidly becoming anif not the mostimportant clinical challenge for indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of such infections, a plethora of biomaterials/bioengineering-based antimicrobial strategies are emerging to restrict or ideally to eliminate microbial adhesion and biofilm formation on implant surfaces. Yet, the development of such approaches faces specific challenges, like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues and antibiotic resistance development, which limit translation to the clinic. This review provides insights into the antimicrobial activity of current state-of-the-art biomaterial-based approaches to address the aforementioned issues. Translational research strategies and regulatory framework are also emphasised as key elements facilitating clinical implementation of anti-infective biomaterials. This review closes with the vision that the integration of computational tools and experimental databases using artificial intelligence (AI) would provide new insights for the accelerated development of next-generation biomaterial-based antimicrobial strategies.

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“…Synthesis of F-108@TPP-AuNPs. Triphenylphosphine (TPP)functionalized and F-108 pluronic polymer-stabilized gold nanoparticles (F-108@TPP-AuNPs) were synthesized according to a previously reported method 48 with some modifications. Briefly, TPP-Au(I)Cl (0.03 mmol) was dissolved and sonicated in a 35-mL vessel with a crimp cap containing 30 mL of 1% F-108 pluronic solution and 90 μL of 1 M NaOH (pH = 10.5).…”

Section: ■ Conclusionmentioning

confidence: 99%

Verification of Nanomaterial-Induced Size-Dependent Human Ether-à-Go-Go-Related Gene Potassium Channel Blockage Using Three-Dimensional Bioengineered Functional Cardiac Tissue Constructs

et al. 2023

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Three-dimensional (3D) bioprinted functional cardiac tissue constructs are proposed for the first time as a screening platform to evaluate the nanomaterial-induced hERG potassium channel blockage based on the in situ measurement of K+ permeation and hERG protein immunofluorescence. Multifunctional anticancer spherical gold nanoparticles whose surface was bound with the ligand of thiol-terminated polyethylene glycol (PEG) conjugated to indomethacin (IMC-PEG-SH@AuNPs) were synthesized with mean diameters of 19, 33, and 64 nm. Triphenylphosphine-stabilized gold nanoparticles (F-108@TPP-AuNPs) were fabricated via temperature- and reaction time-controlled synthesis. Both IMC-PEG-SH@AuNPs and F-108@TPP-AuNPs showed a dose-dependent decrease in K+ permeation because of their binding to hERG proteins. The degree of the hERG potassium channel blockage was dependent on the surface ligand conjugated to the AuNPs. The size-dependent effect of the nanomaterials on the hERG K+ channel block was quantitatively evaluated using the three different sizes of IMC-PEG-SH@AuNPs. The effect of the K+ channel block was remarkably proportional to the size of IMC-PEG-SH@AuNPs. This is the first report demonstrating the size-dependent effect of an hERG K+ channel block induced by nanomaterials. In addition, small molecules showed a greater decrease in K+ permeation and hERG immunofluorescence compared with IMC-PEG-SH@AuNPs because of steric limitations in the binding of surface ligands to hERG proteins.

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Aqueous Synthesis of Triphenylphosphine‐Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy

Cited by 8 publications

References 58 publications

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Verification of Nanomaterial-Induced Size-Dependent Human Ether-à-Go-Go-Related Gene Potassium Channel Blockage Using Three-Dimensional Bioengineered Functional Cardiac Tissue Constructs

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