Pharmacokinetic Model for Procaine in Humans during and following Intravenous Infusion

Smith, Randolph H.; Hunt, Daniel H.; Seifen, Astride B.; Ferrari, A; Thompson, Dola S.

doi:10.1002/jps.2600680826

Cited by 9 publications

(3 citation statements)

References 16 publications

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“… c Value in brackets was estimated for human from nonvalidated pharmacokinetic model simulations of the adipose tissue and plasma concentration–time profiles for intravenous constant infusions of procaine 55…”

Section: Resultsmentioning

confidence: 99%

Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

Poulin¹,

Schoenlein²,

Theil³

2001

Journal of Pharmaceutical Sciences

191

151

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Section: Resultsmentioning

confidence: 99%

Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

Poulin¹,

Schoenlein²,

Theil³

2001

Journal of Pharmaceutical Sciences

191

151

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“…shot of 25 till 50 mg Procaine to reach a systemic action. The pure Procaine infusion was firstly described by SEIFEN et al [37,38] and was mostly used as a continuous treatment in cases of acute pancreatitis [39][40][41] and for epidural anesthesia in infants, children and risk patients, which underlines the low toxicity of the substance [42][43][44][45][46][47][48][49]. O´DONNELL et al reported about the use of procaine infusion to block the cardiac nerves [50].…”

Section: The Procaine-infusion -The Logic Following Of Other Parentermentioning

confidence: 99%

The Procaine-Base-Infusion: a Review after twenty Years of Use

Oettmeier¹,

Reuter²

2017

J Med - Clin Res & Rev

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The highly-dosed infusion with Procaine-HCl with sodium-bicarbonate as additive was firstly published twenty years ago. The method advanced to a routine in many centers for pain treatment, rehabilitation and natural medicine. The aim of the procedure is the systemic use of the various pharmacological features of Procaine, especially to inhibit pain and inflammation, for vasodilatation, anti-oxidation and to harmonize the vegetative nervous system. On one hand shall the addition of sodium-bicarbonate balance the common latent pH-decrease in the periphery. On the other hand also the degradation products of Procaine (DAE and PABA) have a systemic effect. For the safety of the patients and to improve the success rate of the method it was shown that the classic Procaine-Base-infusion should be only realized on the base of a prior acid-base-diagnostic.

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“…In this context, mention can be made of flow-limited models applied to the study of the distribution in humans of methotrexate [88], sulfobromophthalein [89], mercaptopurine [90], barbiturates [91], local anaesthetics such as lidocaine and procaine [92], cocaine [87], or cytarabine [93]. Flow-limited models have recently been used in the field of toxicokinetics for the characterisation of the accumulation of several compounds such as methyl tert-butyl ether [94] or ethylene oxide [95] in different animal species and in humans.…”

Section: Flow-limited Modelsmentioning

confidence: 99%

Drug Tissue Distribution: Study Methods and Therapeutic Implications

Lanao¹,

Fraile²

2005

CPD

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Current interest in studies on tissue distribution stems from the limited capacity to predict tissue concentrations and the pharmacological response from plasma drug levels, and from the limitations - both methodological and deontological- involved in doing so, especially in humans. In this review we carry out a comparative analysis of the methods used for studying tissue distribution, placing special focus on recently developed non-invasive methods for the research of tissue distribution in humans, such as positron emission tomography and nuclear magnetic resonance spectroscopy. We describe the strategies of tissue distribution pharmacokinetic analysis that have evolved from analysis based on compartment and physiological models to analyses based on spatial and fractal models and, mainly, pharmacokinetic-pharmacodynamic models. Model-independent analysis based on the use of mean transit times or deconvolution strategies has become a good alternative for the pharmacokinetic analysis of tissue distribution. The need to increase the selectivity of many drugs justifies the desire to gain further insight into the design of new analogues prodrugs and carrier systems that will guarantee the specific delivery of a given drug to a particular organ or tissue, optimising the response. In silico models for drug distribution have become a helpful tool in drug discovery and development. The therapeutic implications of drug tissue distribution are also analysed, special reference being made to antiretroviral therapy and antitumoural gene therapy, among others.

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Pharmacokinetic Model for Procaine in Humans during and following Intravenous Infusion

Cited by 9 publications

References 16 publications

Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

The Procaine-Base-Infusion: a Review after twenty Years of Use

Drug Tissue Distribution: Study Methods and Therapeutic Implications

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