Pharmacokinetic evaluation of diquafosol tetrasodium for the treatment of Sjögren's syndrome

Bremond-Gignac, Dominique; Gicquel, Jj; Chiambaretta, Frédéric

doi:10.1517/17425255.2014.915026

Cited by 23 publications

(15 citation statements)

References 35 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They showed that topical administration of RvE1 significantly increased tear production and down regulates cyclooxygenase-2 (COX-2) expression, and increased the density of superficial epithelial cells in the dry-eyed mouse model [Li et al, 2010]. Diquafosol is reported to be beneficial in tear film stabilization and repair of corneal epithelial damages [Yarmola et al, 2007;Bremond-Gignac et al, 2014;Byun et al, 2016]. Diquafosol sodium and rebamipide.…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

“…This drug is a P2Y2 purinergic receptor agonist that stimulates the receptors in ocular tissues and thus increases mucin (conjunctival goblet cells stimulation) and the aqueous portion of tear film (conjunctival epithelial cells stimulation) [Shigeyasu et al, 2015]. Diquafosol is reported to be beneficial in tear film stabilization and repair of corneal epithelial damages [Yarmola et al, 2007;Bremond-Gignac et al, 2014;Byun et al, 2016].…”

Section: Medical Managementsmentioning

confidence: 99%

See 1 more Smart Citation

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

View full text Add to dashboard Cite

Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes, and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis, and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain. Corneal abrasions, ulcerations, vesication, and perforations are common corneal consequences in SM injured victims. Appearance of chronic symptoms has been reported as chronic inflammation of the corneal and conjunctival vasculature, ischemia, lipid and cholesterol deposition, scarring in cornea, corneal thinning, opacification and perforation of the cornea, limbal stem cell deficiency (LSCD), and neovascularization. Different medical and surgical protocols have been documented in the management of SM-induced ocular injuries, including preservative-free artificial tears, topical steroids and antibiotic, mydriatic, antiglaucoma drops, therapeutic contact lenses, dark glasses and punctal plugs/cauterization, N-acetylcysteine, tarsorrhaphy, amniotic membrane transplantation, stem cell transplantation, and corneal transplantation. New drugs such as resolvin E1, topical form of essential fatty acids, thymosin β4, 43 amino-acid polypeptides, topical form of curcumin, newly formulated artificial tears, diquafosol, rebamipide, tretinoin, and oral uridineseems to be beneficial in the management of ocular lesion associated with sulfur mustard poisoning. Further studies are needed to approve these drugs in SM victims. J. Cell. Biochem. 118: 3549-3560, 2017. © 2017 Wiley Periodicals, Inc.

show abstract

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

Section: Medical Managementsmentioning

confidence: 99%

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…It acts through a novel mode of action by activating P2Y2 receptors of the ocular surface and stimulating the quantity and quality of tear fluid secretion, as determined by OCT and meniscometry in DE [92].…”

Section: Secretagoguesmentioning

confidence: 99%

“…Therefore, clinical trials demonstrated a good safety profile with clinical improvement of the ocular surface in severe DE patients [92,93] …”

Section: Secretagoguesmentioning

confidence: 99%

Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Nebbioso¹,

Regno²,

Gharbiya³

et al. 2017

Preprint

View full text Add to dashboard Cite

The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome, because the tear film represents the interface between the eye and the environment. Despite having a multifactorial origin, the main risk factors for the emergence of the ocular disease are female gender and advanced age. Peer-reviewed version available at Int. J. Mol. Sci. 2017, 18, 1764 doi:10.3390/ijms18081764 2 Likewise, morphological changes in several glands and in chemical composition of their secretions such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly relevant factors to maintain a condition of good health of the ocular anterior segment. Another key factor of recurrence and onset of the disease is the presence of local and/or systemic infiammation that reflex on the ocular surface. However, it is one of the most commonly encountered disease in clinical practice and many other causes related to daily life and to lengthen the average life will contribute to the beginning. This review will consider how and what disorders of the ocular surface are responsible for a widespread pathology so. In the end, the most appropriate and new therapies will be briefly exposed according to the specific pathology.

show abstract

“…103 Eye irritation was reported as an adverse event in only 6.3% of the cases in a trial of Diquafosol and there were no serious adverse effects. 104 Diquafosol was applied topically because the P2Y 2 R occurs on the ocular surface, and systemic absorption was not detectable and without effect. The enzyme mainly responsible for hydrolysis of the drug in airway epithelial cells was found to be alkaline phosphodiesterase 1 (PDE1), which is membrane bound and has a broad substrate specificity.…”

mentioning

confidence: 99%

Ocular Purine Receptors as Drug Targets in the Eye

Civan

2016

Journal of Ocular Pharmacology and Therapeutics

View full text Add to dashboard Cite

Agonists and antagonists of various subtypes of G protein coupled adenosine receptors (ARs), P2Y receptors (P2YRs), and ATP-gated P2X receptor ion channels (P2XRs) are under consideration as agents for the treatment of ocular diseases, including glaucoma and dry eye. Numerous nucleoside and nonnucleoside modulators of the receptors are available as research tools and potential therapeutic molecules. Three of the 4 subtypes of ARs have been exploited with clinical candidate molecules for treatment of the eye: A 1 , A 2A , and A 3 . An A 1 AR agonist is in clinical trials for glaucoma, A 2A AR reduces neuroinflammation, A 3 AR protects retinal ganglion cells from apoptosis, and both A 3 AR agonists and antagonists had been reported to lower intraocular pressure (IOP). Extracellular concentrations of endogenous nucleotides, including dinucleoside polyphosphates, are increased in pathological states, activating P2Y and P2XRs throughout the eye. P2YR agonists, including P2Y 2 and P2Y 6 , lower IOP. Antagonists of the P2X7R prevent the ATP-induced neuronal apoptosis in the retina. Thus, modulators of the purinome in the eye might be a source of new therapies for ocular diseases.

show abstract

Pharmacokinetic evaluation of diquafosol tetrasodium for the treatment of Sjögren's syndrome

Cited by 23 publications

References 35 publications

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

Ocular Purine Receptors as Drug Targets in the Eye

Contact Info

Product

Resources

About