Pharmacokinetic evaluation and antitumor potency of liposomal nanoparticle encapsulated cisplatin targeted to CD24‑positive cells in ovarian cancer

Ashihara, Kaoru; Tanaka, Tomohito; Tanaka, Yoshimichi; Fujiwara, Satoe; Maeda, Keiko; Tunetoh, Satoshi; Sasaki, Hiroshi; Hayashi, Masami; Ohmichi, Masahide

doi:10.3892/ol.2020.11279

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…The high homology found indicates that monoclonal antibodies and tyrosine kinase receptors developed to identify human CD24 also can identify canine CD24. Ashihara et al [ 12 ] evaluated the pharmacokinetics of a liposomal nanoparticle encapsulated with cisplatin targeted to CD24-positive cells in a xerographic mice model. Since dogs present CD24-positive tumors and CD24 protein have a high protein homology between species, CD24-positive canine prostate cancer can be a valuable model to evaluate the clinical efficiency of this new therapy.…”

Section: Discussionmentioning

confidence: 99%

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A Comparative in Silico Analysis of CD24’s Prognostic Value in Human and Canine Prostate Cancer

Leis-Filho

Lainetti

Franzoni

et al. 2021

JPM

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CD24 is a cell surface molecule anchored by glycosyl-phosphatidyl-inositol and expressed by different human cancers, including prostate cancer (PC). Some studies have demonstrated that CD24 expression is associated with poor patient outcome; however, few studies have investigated CD24 expression in spontaneous animal models of human PC, such as canine PC. This study aimed to evaluate the expression of CD24 in human PC using the in silico analysis of the data obtained from The Cancer Genome Atlas (TCGA) and comparing it with the previously published prostatic canine transcriptome data. In addition, CD24 expression was confirmed by immunohistochemistry in an independent cohort of canine prostatic samples and its prognostic significance assessed. The systematic review identified 10 publications fitting with the inclusion criteria of this study. Of the 10 manuscripts, 5 demonstrated a direct correlation between CD24 overexpression and patient prognoses. CD24 expression was also associated with PSA relapse (2/5) and tumor progression (1/5). However, the in silico analysis did not validate CD24 as a prognostic factor of human PC. Regarding canine PC, 10 out of 30 normal prostates and 27 out of 40 PC samples were positive for CD24. As in humans, there was no association with overall survival. Overall, our results demonstrated a significant CD24 overexpression in human and canine prostate cancer, although its prognostic value may be questionable. However, tumors overexpressing CD24 may be a reliable model for new target therapies and dogs could be used of a unique preclinical model for these studies.

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Section: Discussionmentioning

confidence: 99%

“…CD24 has also been associated with immune evasion through selective binding to macrophage molecules [ 10 ]. Interestingly, one preclinical model targeting CD24 has been developed, a nanoparticle targeting CD24-positive cells and anti-CD24 monoclonal antibodies [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%